The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders

The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of extracellular matrix, which leads to scarring and loss of function of the affected organ or tissue. Indeed, the fibrotic process affects a variety of organs and tissues, with specific molecular background. Howeve...

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Bibliographic Details
Main Authors: Jacopo Di Gregorio, Iole Robuffo, Sonia Spalletta, Giulia Giambuzzi, Vincenzo De Iuliis, Elena Toniato, Stefano Martinotti, Pio Conti, Vincenzo Flati
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
EMT
fibrosis
autophagy
inflammation
TGF-β
SMADs
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.607483/full

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