MicroRNA Expression Profiles and Breast Cancer Chemotherapy
Breast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular characteristics of breast cancer has transformed the trea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/19/10812 |
| _version_ | 1797516252750544896 |
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| author | Matthew G. Davey Aoife J. Lowery Nicola Miller Michael J. Kerin |
| author_facet | Matthew G. Davey Aoife J. Lowery Nicola Miller Michael J. Kerin |
| author_sort | Matthew G. Davey |
| collection | DOAJ |
| description | Breast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular characteristics of breast cancer has transformed the treatment paradigm to include prescription of chemotherapeutical agents, radiotherapies, targeted therapies, as well as more refined surgical approaches. While treatments with such modalities have enhanced clinico-oncological outcomes for breast cancer patients, the efforts of oncological and translational research have concentrated on the identification of novel biomarkers which may successfully inform prognosis and response to therapies, improve current therapeutic strategies, and enhance prognostication. Mi(cro)RNAs are small, non-coding molecules which are known to play regulatory roles in governing gene expression and cellular activity. Measurement of miRNA expression profiles have been illustrated to inform the response to therapies, such as conventional chemotherapy, and are currently undergoing assessment as means of enhancing treatment strategies with these cytotoxic agents. Herein, this review outlines how chemotherapy prescription has revolutionised breast cancer treatment and illustrates the novel role of miRNAs as biomarkers capable of enhancing current therapeutic strategies using chemotherapy in patients being treated with curative intent for breast cancer. |
| first_indexed | 2024-03-10T06:58:39Z |
| format | Article |
| id | doaj.art-2d17141c0c2e4bd389087332d75e367a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:58:39Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2d17141c0c2e4bd389087332d75e367a2023-11-22T16:15:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122191081210.3390/ijms221910812MicroRNA Expression Profiles and Breast Cancer ChemotherapyMatthew G. Davey0Aoife J. Lowery1Nicola Miller2Michael J. Kerin3Department of Surgery, The Lambe Institute for Translational Research, National University of Ireland, Galway, H91 YR71 Galway, IrelandDepartment of Surgery, The Lambe Institute for Translational Research, National University of Ireland, Galway, H91 YR71 Galway, IrelandDepartment of Surgery, The Lambe Institute for Translational Research, National University of Ireland, Galway, H91 YR71 Galway, IrelandDepartment of Surgery, The Lambe Institute for Translational Research, National University of Ireland, Galway, H91 YR71 Galway, IrelandBreast cancer is the most common malignancy diagnosed in women. Traditionally, radical surgical resection was the cornerstone of breast cancer management, with limited exceptions. In recent times, our enhanced appreciation of the biomolecular characteristics of breast cancer has transformed the treatment paradigm to include prescription of chemotherapeutical agents, radiotherapies, targeted therapies, as well as more refined surgical approaches. While treatments with such modalities have enhanced clinico-oncological outcomes for breast cancer patients, the efforts of oncological and translational research have concentrated on the identification of novel biomarkers which may successfully inform prognosis and response to therapies, improve current therapeutic strategies, and enhance prognostication. Mi(cro)RNAs are small, non-coding molecules which are known to play regulatory roles in governing gene expression and cellular activity. Measurement of miRNA expression profiles have been illustrated to inform the response to therapies, such as conventional chemotherapy, and are currently undergoing assessment as means of enhancing treatment strategies with these cytotoxic agents. Herein, this review outlines how chemotherapy prescription has revolutionised breast cancer treatment and illustrates the novel role of miRNAs as biomarkers capable of enhancing current therapeutic strategies using chemotherapy in patients being treated with curative intent for breast cancer.https://www.mdpi.com/1422-0067/22/19/10812breast cancerchemotherapyprecision oncologypersonalised medicinemiRNA |
| spellingShingle | Matthew G. Davey Aoife J. Lowery Nicola Miller Michael J. Kerin MicroRNA Expression Profiles and Breast Cancer Chemotherapy International Journal of Molecular Sciences breast cancer chemotherapy precision oncology personalised medicine miRNA |
| title | MicroRNA Expression Profiles and Breast Cancer Chemotherapy |
| title_full | MicroRNA Expression Profiles and Breast Cancer Chemotherapy |
| title_fullStr | MicroRNA Expression Profiles and Breast Cancer Chemotherapy |
| title_full_unstemmed | MicroRNA Expression Profiles and Breast Cancer Chemotherapy |
| title_short | MicroRNA Expression Profiles and Breast Cancer Chemotherapy |
| title_sort | microrna expression profiles and breast cancer chemotherapy |
| topic | breast cancer chemotherapy precision oncology personalised medicine miRNA |
| url | https://www.mdpi.com/1422-0067/22/19/10812 |
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