Association of serum nesfatin-1 concentrations with atrial fibrillation
Nesfatin-1, a newly discovered adipokine, inhibits inflammatory response. Inflammation is involved in the mechanism of atrial fibrillation (AF). We aim to determine the association between serum nesfatin-1 concentrations and AF. A population of 200 patients with AF and 108 patients without AF were e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-06-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X17302103 |
| _version_ | 1818843924348796928 |
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| author | Xing-Liang Duan Lei Li Ya-Ni Li |
| author_facet | Xing-Liang Duan Lei Li Ya-Ni Li |
| author_sort | Xing-Liang Duan |
| collection | DOAJ |
| description | Nesfatin-1, a newly discovered adipokine, inhibits inflammatory response. Inflammation is involved in the mechanism of atrial fibrillation (AF). We aim to determine the association between serum nesfatin-1 concentrations and AF. A population of 200 patients with AF and 108 patients without AF were enrolled in this study. These patients were divided into three subgroups of paroxysmal AF, persistent AF, and permanent AF. Serum nesfatin-1 concentrations were lower in AF patients than in controls. Logistic regression analysis showed that serum nesfatin-1 concentrations were inversely associated with AF. Serum nesfatin-1 concentrations in permanent AF patients decreased compared with those in persistent and paroxysmal AF groups. In addition, persistent AF patients showed reduced serum nesfatin-1 concentrations compared with paroxysmal AF subjects. Serum nesfatin-1 concentrations were negatively correlated with left atrial diameter. In conclusion, serum nesfatin-1 concentrations were inversely correlated with AF development. Keywords: Nesfatin-1, Atrial fibrillation, Inflammation, Left atrial diameter |
| first_indexed | 2024-12-19T05:05:36Z |
| format | Article |
| id | doaj.art-2d188d63af86415da7c993facd4ee860 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-19T05:05:36Z |
| publishDate | 2018-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-2d188d63af86415da7c993facd4ee8602022-12-21T20:34:56ZengWileyKaohsiung Journal of Medical Sciences1607-551X2018-06-01346348351Association of serum nesfatin-1 concentrations with atrial fibrillationXing-Liang Duan0Lei Li1Ya-Ni Li2Department of Emergency Medicine, Weifang People's Hospital, Shandong, PR ChinaThe Third Department of Health Care, Weifang People's Hospital, Shandong, PR ChinaThe Second Department of Cardiology, Weifang People's Hospital, Shandong, PR China; Corresponding author. The Second Department of Cardiology Weifang People's Hospital, 151 Guangwen Street, 261041, Weifang, Shandong, PR China.Nesfatin-1, a newly discovered adipokine, inhibits inflammatory response. Inflammation is involved in the mechanism of atrial fibrillation (AF). We aim to determine the association between serum nesfatin-1 concentrations and AF. A population of 200 patients with AF and 108 patients without AF were enrolled in this study. These patients were divided into three subgroups of paroxysmal AF, persistent AF, and permanent AF. Serum nesfatin-1 concentrations were lower in AF patients than in controls. Logistic regression analysis showed that serum nesfatin-1 concentrations were inversely associated with AF. Serum nesfatin-1 concentrations in permanent AF patients decreased compared with those in persistent and paroxysmal AF groups. In addition, persistent AF patients showed reduced serum nesfatin-1 concentrations compared with paroxysmal AF subjects. Serum nesfatin-1 concentrations were negatively correlated with left atrial diameter. In conclusion, serum nesfatin-1 concentrations were inversely correlated with AF development. Keywords: Nesfatin-1, Atrial fibrillation, Inflammation, Left atrial diameterhttp://www.sciencedirect.com/science/article/pii/S1607551X17302103 |
| spellingShingle | Xing-Liang Duan Lei Li Ya-Ni Li Association of serum nesfatin-1 concentrations with atrial fibrillation Kaohsiung Journal of Medical Sciences |
| title | Association of serum nesfatin-1 concentrations with atrial fibrillation |
| title_full | Association of serum nesfatin-1 concentrations with atrial fibrillation |
| title_fullStr | Association of serum nesfatin-1 concentrations with atrial fibrillation |
| title_full_unstemmed | Association of serum nesfatin-1 concentrations with atrial fibrillation |
| title_short | Association of serum nesfatin-1 concentrations with atrial fibrillation |
| title_sort | association of serum nesfatin 1 concentrations with atrial fibrillation |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X17302103 |
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