Fructose and Mannose in Inborn Errors of Metabolism and Cancer
History suggests that tasteful properties of sugar have been domesticated as far back as 8000 BCE. With origins in New Guinea, the cultivation of sugar quickly spread over centuries of conquest and trade. The product, which quickly integrated into common foods and onto kitchen tables, is sucrose, wh...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/11/8/479 |
| _version_ | 1827684777512140800 |
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| author | Elizabeth L. Lieu Neil Kelekar Pratibha Bhalla Jiyeon Kim |
| author_facet | Elizabeth L. Lieu Neil Kelekar Pratibha Bhalla Jiyeon Kim |
| author_sort | Elizabeth L. Lieu |
| collection | DOAJ |
| description | History suggests that tasteful properties of sugar have been domesticated as far back as 8000 BCE. With origins in New Guinea, the cultivation of sugar quickly spread over centuries of conquest and trade. The product, which quickly integrated into common foods and onto kitchen tables, is sucrose, which is made up of glucose and fructose dimers. While sugar is commonly associated with flavor, there is a myriad of biochemical properties that explain how sugars as biological molecules function in physiological contexts. Substantial research and reviews have been done on the role of glucose in disease. This review aims to describe the role of its isomers, fructose and mannose, in the context of inborn errors of metabolism and other metabolic diseases, such as cancer. While structurally similar, fructose and mannose give rise to very differing biochemical properties and understanding these differences will guide the development of more effective therapies for metabolic disease. We will discuss pathophysiology linked to perturbations in fructose and mannose metabolism, diagnostic tools, and treatment options of the diseases. |
| first_indexed | 2024-03-10T08:35:58Z |
| format | Article |
| id | doaj.art-2d1af1e860b54885a31238c91312d562 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T08:35:58Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-2d1af1e860b54885a31238c91312d5622023-11-22T08:38:52ZengMDPI AGMetabolites2218-19892021-07-0111847910.3390/metabo11080479Fructose and Mannose in Inborn Errors of Metabolism and CancerElizabeth L. Lieu0Neil Kelekar1Pratibha Bhalla2Jiyeon Kim3Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, IL 60607, USADepartment of Biochemistry and Molecular Genetics, University of Illinois, Chicago, IL 60607, USADepartment of Biochemistry and Molecular Genetics, University of Illinois, Chicago, IL 60607, USADepartment of Biochemistry and Molecular Genetics, University of Illinois, Chicago, IL 60607, USAHistory suggests that tasteful properties of sugar have been domesticated as far back as 8000 BCE. With origins in New Guinea, the cultivation of sugar quickly spread over centuries of conquest and trade. The product, which quickly integrated into common foods and onto kitchen tables, is sucrose, which is made up of glucose and fructose dimers. While sugar is commonly associated with flavor, there is a myriad of biochemical properties that explain how sugars as biological molecules function in physiological contexts. Substantial research and reviews have been done on the role of glucose in disease. This review aims to describe the role of its isomers, fructose and mannose, in the context of inborn errors of metabolism and other metabolic diseases, such as cancer. While structurally similar, fructose and mannose give rise to very differing biochemical properties and understanding these differences will guide the development of more effective therapies for metabolic disease. We will discuss pathophysiology linked to perturbations in fructose and mannose metabolism, diagnostic tools, and treatment options of the diseases.https://www.mdpi.com/2218-1989/11/8/479fructose and mannoseinborn errors of metabolismcancer |
| spellingShingle | Elizabeth L. Lieu Neil Kelekar Pratibha Bhalla Jiyeon Kim Fructose and Mannose in Inborn Errors of Metabolism and Cancer Metabolites fructose and mannose inborn errors of metabolism cancer |
| title | Fructose and Mannose in Inborn Errors of Metabolism and Cancer |
| title_full | Fructose and Mannose in Inborn Errors of Metabolism and Cancer |
| title_fullStr | Fructose and Mannose in Inborn Errors of Metabolism and Cancer |
| title_full_unstemmed | Fructose and Mannose in Inborn Errors of Metabolism and Cancer |
| title_short | Fructose and Mannose in Inborn Errors of Metabolism and Cancer |
| title_sort | fructose and mannose in inborn errors of metabolism and cancer |
| topic | fructose and mannose inborn errors of metabolism cancer |
| url | https://www.mdpi.com/2218-1989/11/8/479 |
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