Patients with postprandial distress syndrome experience problems with their interoceptive perceptual function to the gastric region, but their heartbeat perception is normal: a case control study
Abstract Background Visceral hypersensitivity in functional dyspepsia can be localized or widespread, and there is no simple method of assessment. Measuring interoceptive accuracy at different sites provides an assessment of perceptual hypersensitivity to specific ecological phenomena. The purpose o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BioPsychoSocial Medicine |
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| Online Access: | https://doi.org/10.1186/s13030-023-00290-5 |
| _version_ | 1797558785930166272 |
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| author | Kohei Yoshida Tetsuya Abe Kenji Kanbara Kento Ueda Yukie Saka-Kouchi Hideaki Hasuo |
| author_facet | Kohei Yoshida Tetsuya Abe Kenji Kanbara Kento Ueda Yukie Saka-Kouchi Hideaki Hasuo |
| author_sort | Kohei Yoshida |
| collection | DOAJ |
| description | Abstract Background Visceral hypersensitivity in functional dyspepsia can be localized or widespread, and there is no simple method of assessment. Measuring interoceptive accuracy at different sites provides an assessment of perceptual hypersensitivity to specific ecological phenomena. The purpose of this study was to characterize visceral hypersensitivity by comparing gastric sensory and cardiac perceptual tests in patients with postprandial distress syndrome and in healthy volunteers. Methods Sixteen patients with postprandial distress syndrome (age = 47.5 ± 17.4, all female) and 16 healthy volunteers (age = 43.3 ± 16.1, all female) participated in the study after a six-hour fast. Each participant answered questionnaires about physical and mental quality of life, depression and anxiety, tendency of alexithymia, and somatosensory amplification. After completing the questionnaire, the participants took the heartbeat tracking task and the five-minute water load test. We performed statistical analysis using the Mann–Whitney U test and Spearman’s rank correlation coefficient. Results Subjects with postprandial distress syndrome had a lower drinking capacity than healthy volunteers (postprandial distress syndrome = 360.9 ± 170.0 mL, healthy volunteers = 644.1 ± 297 mL, P = 0.009), but there was no significant difference in the heartbeat perception score (postprandial distress syndrome = 0.599 ± 0.175, healthy volunteers = 0.623 ± 0.181, P = 0.647). There was a negative correlation (r = − 0.509, P < 0.05) between drinking capacity and the heartbeat perception score in healthy volunteers, but no correlation in postprandial distress syndrome (r = − 0.156, P = 0.564). Heartbeat perception score did not correlate with psychological measures. Conclusions Compared with healthy volunteers, only the five-minute water load test values were reduced in patients with postprandial distress syndrome, and no difference was observed in the heartbeat tracking task. Combining the 5-minute water load test and the heart rate tracking task revealed a lost cardiac-gastric perceptual relationship in patients with postprandial distress syndrome that was not observed in healthy volunteers, suggesting that there is hypersensitivity in gastric interoceptive perceptual function. Performing sensory examinations at two different sites may be useful in clarifying whether visceral hypersensitivity is localized. Trial registration UMIN000057586. Registered11 March 2023(retrospectively registered). |
| first_indexed | 2024-03-10T17:36:18Z |
| format | Article |
| id | doaj.art-2d1c3b77e5804d538f40e9d124f72d70 |
| institution | Directory Open Access Journal |
| issn | 1751-0759 |
| language | English |
| last_indexed | 2024-03-10T17:36:18Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
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| series | BioPsychoSocial Medicine |
| spelling | doaj.art-2d1c3b77e5804d538f40e9d124f72d702023-11-20T09:50:43ZengBMCBioPsychoSocial Medicine1751-07592023-10-011711810.1186/s13030-023-00290-5Patients with postprandial distress syndrome experience problems with their interoceptive perceptual function to the gastric region, but their heartbeat perception is normal: a case control studyKohei Yoshida0Tetsuya Abe1Kenji Kanbara2Kento Ueda3Yukie Saka-Kouchi4Hideaki Hasuo5Department of Psychosomatic and General Internal Medicine, Kansai Medical UniversityDepartment of Psychosomatic and General Internal Medicine, Kansai Medical UniversityDepartment of Psychosomatic and General Internal Medicine, Kansai Medical UniversityDepartment of Psychosomatic and General Internal Medicine, Kansai Medical UniversityDepartment of Psychosomatic and General Internal Medicine, Kansai Medical UniversityDepartment of Psychosomatic and General Internal Medicine, Kansai Medical UniversityAbstract Background Visceral hypersensitivity in functional dyspepsia can be localized or widespread, and there is no simple method of assessment. Measuring interoceptive accuracy at different sites provides an assessment of perceptual hypersensitivity to specific ecological phenomena. The purpose of this study was to characterize visceral hypersensitivity by comparing gastric sensory and cardiac perceptual tests in patients with postprandial distress syndrome and in healthy volunteers. Methods Sixteen patients with postprandial distress syndrome (age = 47.5 ± 17.4, all female) and 16 healthy volunteers (age = 43.3 ± 16.1, all female) participated in the study after a six-hour fast. Each participant answered questionnaires about physical and mental quality of life, depression and anxiety, tendency of alexithymia, and somatosensory amplification. After completing the questionnaire, the participants took the heartbeat tracking task and the five-minute water load test. We performed statistical analysis using the Mann–Whitney U test and Spearman’s rank correlation coefficient. Results Subjects with postprandial distress syndrome had a lower drinking capacity than healthy volunteers (postprandial distress syndrome = 360.9 ± 170.0 mL, healthy volunteers = 644.1 ± 297 mL, P = 0.009), but there was no significant difference in the heartbeat perception score (postprandial distress syndrome = 0.599 ± 0.175, healthy volunteers = 0.623 ± 0.181, P = 0.647). There was a negative correlation (r = − 0.509, P < 0.05) between drinking capacity and the heartbeat perception score in healthy volunteers, but no correlation in postprandial distress syndrome (r = − 0.156, P = 0.564). Heartbeat perception score did not correlate with psychological measures. Conclusions Compared with healthy volunteers, only the five-minute water load test values were reduced in patients with postprandial distress syndrome, and no difference was observed in the heartbeat tracking task. Combining the 5-minute water load test and the heart rate tracking task revealed a lost cardiac-gastric perceptual relationship in patients with postprandial distress syndrome that was not observed in healthy volunteers, suggesting that there is hypersensitivity in gastric interoceptive perceptual function. Performing sensory examinations at two different sites may be useful in clarifying whether visceral hypersensitivity is localized. Trial registration UMIN000057586. Registered11 March 2023(retrospectively registered).https://doi.org/10.1186/s13030-023-00290-5Postprandial distress syndromeInteroceptive accuracyHeartbeat tracking taskFive-minute water load testVisceral hypersensitivity |
| spellingShingle | Kohei Yoshida Tetsuya Abe Kenji Kanbara Kento Ueda Yukie Saka-Kouchi Hideaki Hasuo Patients with postprandial distress syndrome experience problems with their interoceptive perceptual function to the gastric region, but their heartbeat perception is normal: a case control study BioPsychoSocial Medicine Postprandial distress syndrome Interoceptive accuracy Heartbeat tracking task Five-minute water load test Visceral hypersensitivity |
| title | Patients with postprandial distress syndrome experience problems with their interoceptive perceptual function to the gastric region, but their heartbeat perception is normal: a case control study |
| title_full | Patients with postprandial distress syndrome experience problems with their interoceptive perceptual function to the gastric region, but their heartbeat perception is normal: a case control study |
| title_fullStr | Patients with postprandial distress syndrome experience problems with their interoceptive perceptual function to the gastric region, but their heartbeat perception is normal: a case control study |
| title_full_unstemmed | Patients with postprandial distress syndrome experience problems with their interoceptive perceptual function to the gastric region, but their heartbeat perception is normal: a case control study |
| title_short | Patients with postprandial distress syndrome experience problems with their interoceptive perceptual function to the gastric region, but their heartbeat perception is normal: a case control study |
| title_sort | patients with postprandial distress syndrome experience problems with their interoceptive perceptual function to the gastric region but their heartbeat perception is normal a case control study |
| topic | Postprandial distress syndrome Interoceptive accuracy Heartbeat tracking task Five-minute water load test Visceral hypersensitivity |
| url | https://doi.org/10.1186/s13030-023-00290-5 |
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