Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer
Here the authors identify retinoblastoma (RB) protein as an intrinsic inhibitor of BRD4 and demonstrate that loss of RB induces BRD4 cistrome changes in the genome and enrichment of GPCR-cAMP signaling pathway, conferring resistance to small molecule BET inhibitor.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34024-y |
| _version_ | 1811336311540285440 |
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| author | Donglin Ding Rongbin Zheng Ye Tian Rafael Jimenez Xiaonan Hou Saravut J. Weroha Liguo Wang Lei Shi Haojie Huang |
| author_facet | Donglin Ding Rongbin Zheng Ye Tian Rafael Jimenez Xiaonan Hou Saravut J. Weroha Liguo Wang Lei Shi Haojie Huang |
| author_sort | Donglin Ding |
| collection | DOAJ |
| description | Here the authors identify retinoblastoma (RB) protein as an intrinsic inhibitor of BRD4 and demonstrate that loss of RB induces BRD4 cistrome changes in the genome and enrichment of GPCR-cAMP signaling pathway, conferring resistance to small molecule BET inhibitor. |
| first_indexed | 2024-04-13T17:37:34Z |
| format | Article |
| id | doaj.art-2d1d3c9ab3354c74b4af0e72ef46ad75 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T17:37:34Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2d1d3c9ab3354c74b4af0e72ef46ad752022-12-22T02:37:17ZengNature PortfolioNature Communications2041-17232022-10-0113111510.1038/s41467-022-34024-yRetinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancerDonglin Ding0Rongbin Zheng1Ye Tian2Rafael Jimenez3Xiaonan Hou4Saravut J. Weroha5Liguo Wang6Lei Shi7Haojie Huang8Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and ScienceBasic and Translational Research Division, Department of Cardiology, Boston Children’s HospitalDepartment of Urology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese MedicineDepartment of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine and ScienceDivison of Oncology, Mayo Clinic College of Medicine and ScienceDivison of Oncology, Mayo Clinic College of Medicine and ScienceDivison of Medical Informatics and Statistics, Mayo Clinic College of Medicine and ScienceDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and ScienceDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and ScienceHere the authors identify retinoblastoma (RB) protein as an intrinsic inhibitor of BRD4 and demonstrate that loss of RB induces BRD4 cistrome changes in the genome and enrichment of GPCR-cAMP signaling pathway, conferring resistance to small molecule BET inhibitor.https://doi.org/10.1038/s41467-022-34024-y |
| spellingShingle | Donglin Ding Rongbin Zheng Ye Tian Rafael Jimenez Xiaonan Hou Saravut J. Weroha Liguo Wang Lei Shi Haojie Huang Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer Nature Communications |
| title | Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer |
| title_full | Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer |
| title_fullStr | Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer |
| title_full_unstemmed | Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer |
| title_short | Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer |
| title_sort | retinoblastoma protein as an intrinsic brd4 inhibitor modulates small molecule bet inhibitor sensitivity in cancer |
| url | https://doi.org/10.1038/s41467-022-34024-y |
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