Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function
The past decade witnessed a huge interest in the communication machinery called tunneling nanotubes (TNTs) which is a novel, contact-dependent type of intercellular protein transfer (IPT). As the IPT phenomenon plays a particular role in the cross-talk between cells, including cancer cells as well a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.915117/full |
| _version_ | 1811297174294626304 |
|---|---|
| author | Laura Turos-Korgul Marta Dorota Kolba Piotr Chroscicki Aleksandra Zieminska Katarzyna Piwocka |
| author_facet | Laura Turos-Korgul Marta Dorota Kolba Piotr Chroscicki Aleksandra Zieminska Katarzyna Piwocka |
| author_sort | Laura Turos-Korgul |
| collection | DOAJ |
| description | The past decade witnessed a huge interest in the communication machinery called tunneling nanotubes (TNTs) which is a novel, contact-dependent type of intercellular protein transfer (IPT). As the IPT phenomenon plays a particular role in the cross-talk between cells, including cancer cells as well as in the immune and nervous systems, it therefore participates in remodeling of the cellular networks. The following review focuses on the placing the role of tunneling nanotube-mediated protein transfer between distant cells. Firstly, we describe different screening methods used to study IPT including tunneling nanotubes. Further, we present various examples of TNT-mediated protein transfer in the immune system, cancer microenvironment and in the nervous system, with particular attention to the methods used to verify the transfer of individual proteins. |
| first_indexed | 2024-04-13T06:00:13Z |
| format | Article |
| id | doaj.art-2d1d57caba2e42bbbf170d154c57b563 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T06:00:13Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-2d1d57caba2e42bbbf170d154c57b5632022-12-22T02:59:28ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-07-011010.3389/fcell.2022.915117915117Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks FunctionLaura Turos-KorgulMarta Dorota KolbaPiotr ChroscickiAleksandra ZieminskaKatarzyna PiwockaThe past decade witnessed a huge interest in the communication machinery called tunneling nanotubes (TNTs) which is a novel, contact-dependent type of intercellular protein transfer (IPT). As the IPT phenomenon plays a particular role in the cross-talk between cells, including cancer cells as well as in the immune and nervous systems, it therefore participates in remodeling of the cellular networks. The following review focuses on the placing the role of tunneling nanotube-mediated protein transfer between distant cells. Firstly, we describe different screening methods used to study IPT including tunneling nanotubes. Further, we present various examples of TNT-mediated protein transfer in the immune system, cancer microenvironment and in the nervous system, with particular attention to the methods used to verify the transfer of individual proteins.https://www.frontiersin.org/articles/10.3389/fcell.2022.915117/fullintercellular protein transferproteomecellular networktunneling nanotubes (TNT)SILAC mass spectrometrycodeIT |
| spellingShingle | Laura Turos-Korgul Marta Dorota Kolba Piotr Chroscicki Aleksandra Zieminska Katarzyna Piwocka Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function Frontiers in Cell and Developmental Biology intercellular protein transfer proteome cellular network tunneling nanotubes (TNT) SILAC mass spectrometry codeIT |
| title | Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function |
| title_full | Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function |
| title_fullStr | Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function |
| title_full_unstemmed | Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function |
| title_short | Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function |
| title_sort | tunneling nanotubes facilitate intercellular protein transfer and cell networks function |
| topic | intercellular protein transfer proteome cellular network tunneling nanotubes (TNT) SILAC mass spectrometry codeIT |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.915117/full |
| work_keys_str_mv | AT lauraturoskorgul tunnelingnanotubesfacilitateintercellularproteintransferandcellnetworksfunction AT martadorotakolba tunnelingnanotubesfacilitateintercellularproteintransferandcellnetworksfunction AT piotrchroscicki tunnelingnanotubesfacilitateintercellularproteintransferandcellnetworksfunction AT aleksandrazieminska tunnelingnanotubesfacilitateintercellularproteintransferandcellnetworksfunction AT katarzynapiwocka tunnelingnanotubesfacilitateintercellularproteintransferandcellnetworksfunction |