QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report
Diphenhydramine is a widely available, over-the-counter medication used for allergies and as a sleeping aid. When used in prescription doses, it is generally safe. Overdose of the medication has been associated with dangerous and life-threatening outcomes. Our case describes diphenhydramine toxicity...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Greater Baltimore Medical Center
2020-03-01
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| Series: | Journal of Community Hospital Internal Medicine Perspectives |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/20009666.2020.1749511 |
| _version_ | 1797965955336241152 |
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| author | Zain Ali Mariya Khan Waqas Ullah Atsoufui A. Kpehor Muhammad Arslan Cheema |
| author_facet | Zain Ali Mariya Khan Waqas Ullah Atsoufui A. Kpehor Muhammad Arslan Cheema |
| author_sort | Zain Ali |
| collection | DOAJ |
| description | Diphenhydramine is a widely available, over-the-counter medication used for allergies and as a sleeping aid. When used in prescription doses, it is generally safe. Overdose of the medication has been associated with dangerous and life-threatening outcomes. Our case describes diphenhydramine toxicity manifesting with two rare but potentially life-threatening complications, rhabdomyolysis, and QT prolongation. Laboratory testing for diphenhydramine levels are not widely available. We recommend a high degree of suspicion for these complications when evaluating patients with diphenhydramine overdose, to adequately manage and prevent untoward outcomes. |
| first_indexed | 2024-04-11T02:07:06Z |
| format | Article |
| id | doaj.art-2d1fa449e5be47a29ebfffa7300eed88 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T02:07:06Z |
| publishDate | 2020-03-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-2d1fa449e5be47a29ebfffa7300eed882023-01-03T02:49:41ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662020-03-0110215115310.1080/20009666.2020.17495111749511QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case reportZain Ali0Mariya Khan1Waqas Ullah2Atsoufui A. Kpehor3Muhammad Arslan Cheema4Abington Memorial HospitalDow University of Health SciencesAbington Memorial HospitalAbington Memorial HospitalAbington Memorial HospitalDiphenhydramine is a widely available, over-the-counter medication used for allergies and as a sleeping aid. When used in prescription doses, it is generally safe. Overdose of the medication has been associated with dangerous and life-threatening outcomes. Our case describes diphenhydramine toxicity manifesting with two rare but potentially life-threatening complications, rhabdomyolysis, and QT prolongation. Laboratory testing for diphenhydramine levels are not widely available. We recommend a high degree of suspicion for these complications when evaluating patients with diphenhydramine overdose, to adequately manage and prevent untoward outcomes.http://dx.doi.org/10.1080/20009666.2020.1749511diphenhydramine toxicityanticholinergic toxidromerhabdomyolysisqtc prolongation |
| spellingShingle | Zain Ali Mariya Khan Waqas Ullah Atsoufui A. Kpehor Muhammad Arslan Cheema QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report Journal of Community Hospital Internal Medicine Perspectives diphenhydramine toxicity anticholinergic toxidrome rhabdomyolysis qtc prolongation |
| title | QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report |
| title_full | QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report |
| title_fullStr | QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report |
| title_full_unstemmed | QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report |
| title_short | QT interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity: a case report |
| title_sort | qt interval prolongation and rhabdomyolysis associated with diphenhydramine toxicity a case report |
| topic | diphenhydramine toxicity anticholinergic toxidrome rhabdomyolysis qtc prolongation |
| url | http://dx.doi.org/10.1080/20009666.2020.1749511 |
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