Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice

Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice

Caloric restriction (CR) slows the aging process, extends lifespan, and exerts neuroprotective effects. It is widely accepted that CR attenuates β-amyloid (Aβ) neuropathology in models of Alzheimer’s disease (AD) by so-far unknown mechanisms. One promising process induced by CR is autophagy, which i...

Full description

Bibliographic Details
Main Authors:	Luisa Müller, Nicole Power Guerra, Jan Stenzel, Claire Rühlmann, Tobias Lindner, Bernd J. Krause, Brigitte Vollmar, Stefan Teipel, Angela Kuhla
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Nutrients
Subjects:	APPswe/PS1delta9 caloric restriction [<sup>18</sup>F]FDG-PET/CT amyloid β iba1 autophagy
Online Access:	https://www.mdpi.com/2072-6643/13/3/985

Similar Items

[<sup>18</sup>F]GE-180-PET and Post Mortem Marker Characteristics of Long-Term High-Fat-Diet-Induced Chronic Neuroinflammation in Mice
by: Luisa Müller, et al.
Published: (2023-04-01)

EK100 and Antrodin C Improve Brain Amyloid Pathology in APP/PS1 Transgenic Mice by Promoting Microglial and Perivascular Clearance Pathways
by: Huey-Jen Tsay, et al.
Published: (2021-09-01)

Long-Term Sex- and Genotype-Specific Effects of <sup>56</sup>Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice
by: Maren K. Schroeder, et al.
Published: (2021-12-01)

Is There a Role for [<sup>18</sup>F]FDG PET-CT in Staging MALT Lymphoma?
by: Dan Cohen, et al.
Published: (2022-01-01)

A Prospective Investigation of Tumor Hypoxia Imaging with <sup>68</sup>Ga-Nitroimidazole PET/CT in Patients with Carcinoma of the Cervix Uteri and Comparison with <sup>18</sup>F-FDG PET/CT: Correlation with Immunohistochemistry
by: Kgomotso M. G. Mokoala, et al.
Published: (2022-02-01)

A Magtein<sup>®</sup>, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults
by: Chengxiang Zhang, et al.
Published: (2022-12-01)

A Diet Containing Rutin Ameliorates Brain Intracellular Redox Homeostasis in a Mouse Model of Alzheimer’s Disease
by: Paloma Bermejo-Bescós, et al.
Published: (2023-03-01)

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization
by: Elena Sánchez-López, et al.
Published: (2018-03-01)

Advances in Molecular Imaging in Infective Endocarditis
by: Katarzyna Holcman, et al.
Published: (2023-02-01)

Retrospective Analysis of the Predictive Value of <sup>18</sup>F-FDG PET/CT Metabolic Parameters for PD-L1 Expression in Cervical Cancer
by: Jianfeng Ji, et al.
Published: (2023-03-01)

Pulmonary and Liver Toxocariasis Mimicking Metastatic Tumors in a Patient with Colon Cancer
by: Miju Cheon, et al.
Published: (2023-12-01)

Intense FDG Uptake in the Common Bile Duct Post-ERCP Mimics Acute Infectious Cholangitis
by: Neel P. Mistry, et al.
Published: (2022-12-01)

The Additional Value of <sup>18</sup>F-FDG PET and MRI in Patients with Glioma: A Review of the Literature from 2015 to 2020
by: Natale Quartuccio, et al.
Published: (2020-05-01)

Isotopic Tracer Study of Initiation of Porosity in Anodic Alumina Formed in Chromic Acid
by: Aleksandra Baron-Wiechec, et al.
Published: (2023-12-01)

If It Works, Don’t Touch It? A Cell-Based Approach to Studying 2-[<sup>18</sup>F]FDG Metabolism
by: Eva-Maria Klebermass, et al.
Published: (2021-09-01)

Choline PET/CT in Multiple Myeloma
by: Charles Mesguich, et al.
Published: (2020-05-01)

Glycolytic Plasticity of Metastatic Lung Cancer Captured by Noninvasive <sup>18</sup>F-FDG PET/CT and Serum <sup>1</sup>H-NMR Analysis: An Orthotopic Murine Model Study
by: Yi-Hsiu Chung, et al.
Published: (2023-01-01)

CXCR4-Directed PET/CT in Patients with Newly Diagnosed Neuroendocrine Carcinomas
by: Alexander Weich, et al.
Published: (2021-03-01)

3D Convolutional Neural Network-Based Denoising of Low-Count Whole-Body <sup>18</sup>F-Fluorodeoxyglucose and <sup>89</sup>Zr-Rituximab PET Scans
by: Bart M. de Vries, et al.
Published: (2022-02-01)

Different Uptake of <sup>68</sup>Ga-FAPI and <sup>18</sup>F-FDG in Lymphadenopathy Caused by Angioimmunoblastic T-Cell Lymphoma in a Patient with Colon Cancer
by: Meiqi Wu, et al.
Published: (2022-09-01)

<sup>64</sup>CuCl<sub>2</sub> PET Imaging of 4T1-Related Allograft of Triple-Negative Breast Cancer in Mice
by: Adrien Latgé, et al.
Published: (2022-07-01)

Clinical Utility of <sup>18</sup>F-FDG PET in Neuroendocrine Tumors Prior to Peptide Receptor Radionuclide Therapy: A Systematic Review and Meta-Analysis
by: Emmanouil Alevroudis, et al.
Published: (2021-04-01)

Clinical and Radiological Features Predicting Intervertebral Autofusion after Successful Antibiotic Therapy in Pyogenic Vertebral Osteomyelitis
by: Insu Seong, et al.
Published: (2021-07-01)

Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease
by: Cátia R. Lopes, et al.
Published: (2023-04-01)

Tumor Burden of Iodine-Avid Bone Metastatic Thyroid Cancer Identified via <sup>18</sup>F-Sodium Fluoride PET/CT Imaging
by: Carmela Nappi, et al.
Published: (2024-01-01)

Image Quality and Quantitative PET Parameters of Low-Dose [<sup>18</sup>F]FDG PET in a Long Axial Field-of-View PET/CT Scanner
by: Eduardo Calderón, et al.
Published: (2023-10-01)

Comparison of <sup>18</sup>F-FDG PET/CT and <sup>68</sup>Ga-FAPI in Spindle Cell Rhabdomyosarcoma
by: Zhihui Shen, et al.
Published: (2023-09-01)

A Retrospective Analysis of the Correlation between Functional Imaging and Clinical Outcomes in Grade 3 Neuroendocrine Tumors (NETs G3)
by: Alice Laffi, et al.
Published: (2021-12-01)

Heterotridentate Organomonophosphines in Pt(κ<sup>3</sup>–X<sup>1</sup>P<sup>1</sup>X<sup>2</sup>)(Y) (X<sup>1,2</sup> = N<sup>1,2</sup> or S<sup>1,2</sup>), Pt(κ<sup>3</sup>–P<sup>1</sup>N<sup>1</sup>X<sup>1</sup>)(Y) (X<sup>1</sup> = O, C, S or Se) Pt(κ<sup>3</sup>–P<sup>1</sup>S<sup>1</sup>Cl<sup>1</sup>)(Cl) and Pt(κ<sup>3</sup>–P<sup>1</sup>Si<sup>1</sup>N<sup>1</sup>)(OL)—Structural Aspects
by: Milan Melník, et al.
Published: (2022-12-01)

Beyond Activation: Characterizing Microglial Functional Phenotypes
by: Julia Lier, et al.
Published: (2021-08-01)

What Does PET Imaging Bring to Neuro-Oncology in 2022? A Review
by: Jules Tianyu Zhang-Yin, et al.
Published: (2022-02-01)

New Targets for PET Imaging of Myeloma
by: Mona-Elisabeth Revheim, et al.
Published: (2021-12-01)

Evidence for a protective effect of the loss of α4-containing nicotinic acetylcholine receptors on Aβ-related neuropathology in Tg2576 mice
by: Antonietta Vilella, et al.
Published: (2023-04-01)

<sup>18</sup>F-FDG PET Is Not Inferior to <sup>68</sup>Ga-PSMA PET for Detecting Biochemical Recurrent Prostate Cancer with a High Gleason Score: A Head-to-Head Comparison Study
by: Lian Xu, et al.
Published: (2023-12-01)

A Systematic Review on Combined [<sup>18</sup>F]FDG and <sup>68</sup>Ga-SSA PET/CT in Pulmonary Carcinoid
by: Daniela Prosperi, et al.
Published: (2023-05-01)

Diagnosis, Management and Theragnostic Approach of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms
by: Leandra Piscopo, et al.
Published: (2023-07-01)

Nuclear Medicine and Radiological Imaging of Pancreatic Neuroendocrine Neoplasms: A Multidisciplinary Update
by: Daniela Prosperi, et al.
Published: (2022-11-01)

PET-Based Imaging with <sup>18</sup>F-FDG and <sup>18</sup>F-NaF to Assess Inflammation and Microcalcification in Atherosclerosis and Other Vascular and Thrombotic Disorders
by: William Y. Raynor, et al.
Published: (2021-11-01)

The Role of Molecular Imaging in Patients with Brain Metastases: A Literature Review
by: Luca Urso, et al.
Published: (2023-04-01)

Usefulness of <sup>18</sup>F-FDG PET-CT in the Management of Febrile Neutropenia: A Retrospective Cohort from a Tertiary University Hospital and a Systematic Review
by: Andrea Gutiérrez-Villanueva, et al.
Published: (2024-01-01)