Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications
Ferroptosis refers to a novel modality of regulated cell death characterized by excessive iron accumulation and overwhelming lipid peroxidation, which takes an important part in multiple pathological processes associated with cell death. Considering the crucial roles of the liver in iron and lipid m...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1090338/full |
| _version_ | 1797884394714693632 |
|---|---|
| author | Zilu Cheng Huikuan Chu Qingjing Zhu Ling Yang |
| author_facet | Zilu Cheng Huikuan Chu Qingjing Zhu Ling Yang |
| author_sort | Zilu Cheng |
| collection | DOAJ |
| description | Ferroptosis refers to a novel modality of regulated cell death characterized by excessive iron accumulation and overwhelming lipid peroxidation, which takes an important part in multiple pathological processes associated with cell death. Considering the crucial roles of the liver in iron and lipid metabolism and its predisposition to oxidative insults, more and more studies have been conducted to explore the relationship between ferroptosis and various liver disorders, including non-alcoholic fatty liver disease (NAFLD). With increased morbidity and high mortality rates, NAFLD has currently emerged as a global public health issue. However, the etiology of NAFLD is not fully understood. In recent years, an accumulating body of evidence have suggested that ferroptosis plays a pivotal role in the pathogenesis of NAFLD, but the precise mechanisms underlying how ferroptosis affects NAFLD still remain obscure. Here, we summarize the molecular mechanisms of ferroptosis and its complicated regulation systems, delineate the different effects that ferroptosis exerts in different stages of NAFLD, and discuss some potential effective therapies targeting ferroptosis for NAFLD treatment, which putatively points out a novel direction for NAFLD treatment. |
| first_indexed | 2024-04-10T04:06:58Z |
| format | Article |
| id | doaj.art-2d21baa5e8c54b0cbc885515f1eb50e9 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-10T04:06:58Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-2d21baa5e8c54b0cbc885515f1eb50e92023-03-13T04:42:22ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-03-011010.3389/fnut.2023.10903381090338Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implicationsZilu Cheng0Huikuan Chu1Qingjing Zhu2Ling Yang3Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaJinyintan Hospital, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaFerroptosis refers to a novel modality of regulated cell death characterized by excessive iron accumulation and overwhelming lipid peroxidation, which takes an important part in multiple pathological processes associated with cell death. Considering the crucial roles of the liver in iron and lipid metabolism and its predisposition to oxidative insults, more and more studies have been conducted to explore the relationship between ferroptosis and various liver disorders, including non-alcoholic fatty liver disease (NAFLD). With increased morbidity and high mortality rates, NAFLD has currently emerged as a global public health issue. However, the etiology of NAFLD is not fully understood. In recent years, an accumulating body of evidence have suggested that ferroptosis plays a pivotal role in the pathogenesis of NAFLD, but the precise mechanisms underlying how ferroptosis affects NAFLD still remain obscure. Here, we summarize the molecular mechanisms of ferroptosis and its complicated regulation systems, delineate the different effects that ferroptosis exerts in different stages of NAFLD, and discuss some potential effective therapies targeting ferroptosis for NAFLD treatment, which putatively points out a novel direction for NAFLD treatment.https://www.frontiersin.org/articles/10.3389/fnut.2023.1090338/fullferroptosisiron metabolismnonalcoholic liver diseasetime-restricted feedingenoyl coenzyme A hydratase 1 |
| spellingShingle | Zilu Cheng Huikuan Chu Qingjing Zhu Ling Yang Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications Frontiers in Nutrition ferroptosis iron metabolism nonalcoholic liver disease time-restricted feeding enoyl coenzyme A hydratase 1 |
| title | Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications |
| title_full | Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications |
| title_fullStr | Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications |
| title_full_unstemmed | Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications |
| title_short | Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications |
| title_sort | ferroptosis in non alcoholic liver disease molecular mechanisms and therapeutic implications |
| topic | ferroptosis iron metabolism nonalcoholic liver disease time-restricted feeding enoyl coenzyme A hydratase 1 |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1090338/full |
| work_keys_str_mv | AT zilucheng ferroptosisinnonalcoholicliverdiseasemolecularmechanismsandtherapeuticimplications AT huikuanchu ferroptosisinnonalcoholicliverdiseasemolecularmechanismsandtherapeuticimplications AT qingjingzhu ferroptosisinnonalcoholicliverdiseasemolecularmechanismsandtherapeuticimplications AT lingyang ferroptosisinnonalcoholicliverdiseasemolecularmechanismsandtherapeuticimplications |