Proteostasis unbalance in prion diseases: Mechanisms of neurodegeneration and therapeutic targets

Proteostasis unbalance in prion diseases: Mechanisms of neurodegeneration and therapeutic targets

Transmissible spongiform encephalopathies (TSEs), or prion diseases, are progressive neurodegenerative disorders of the central nervous system that affect humans and animals as sporadic, inherited, and infectious forms. Similarly to Alzheimer's disease and other neurodegenerative disorders, any...

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Bibliographic Details
Main Authors: Stefano Thellung, Alessandro Corsaro, Irene Dellacasagrande, Mario Nizzari, Martina Zambito, Tullio Florio
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Neuroscience
Subjects:
prion protein
protein misfolding
autophagy
proteasome
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.966019/full

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