Synthesis of Some novel Azomethine Oxide Derived from Aromatic Oximes and their Anti-microbial Studies
The organic compound category known as azomethine oxides has garnered significant attention due to its potential for bioactive and pharmacological effects, as well as its role in organic syntheses. Existing literature offers various methods for producing derivatives of these compounds. This study...
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| Format: | Article |
| Language: | English |
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Koya University
2024-02-01
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| Series: | ARO-The Scientific Journal of Koya University |
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| Online Access: | https://aro.koyauniversity.org/index.php/aro/article/view/1471 |
| _version_ | 1797304884408614912 |
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| author | Jihad H. Mohammed Akram N. Qaddo Nabaz A. Muhammad Faeza B. Omar |
| author_facet | Jihad H. Mohammed Akram N. Qaddo Nabaz A. Muhammad Faeza B. Omar |
| author_sort | Jihad H. Mohammed |
| collection | DOAJ |
| description |
The organic compound category known as azomethine oxides has garnered significant attention due to its potential for bioactive and pharmacological effects, as well as its role in organic syntheses. Existing literature offers various methods for producing derivatives of these compounds. This study, in particular, concentrates on the creation of several aromatic oximes through the reduction of corresponding aldehydes. Furthermore, these oximes are employed in the generation of new azomethine oxides through a condensation reaction with selected aldehydes. The molecular structure of the synthesized azomethine oxides is determined using techniques such as Fourier-transform infrared spectroscopy, 1H-NMR, and 13C-NMR. Finally, the antimicrobial effectiveness of these compounds was assessed against Escherichia coli (gram-negative bacteria), Staphylococcus aureus (gram-positive bacteria), and Candida albicans (fungus). The synthesized compounds were obtained with high purity and yielded excellent results. Furthermore, the data demonstrates that these azomethine oxides exhibit significant antimicrobial activity when compared to standard drugs.
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| first_indexed | 2024-03-08T00:16:50Z |
| format | Article |
| id | doaj.art-2d221eb381674424aaf9710218c37622 |
| institution | Directory Open Access Journal |
| issn | 2410-9355 2307-549X |
| language | English |
| last_indexed | 2024-03-08T00:16:50Z |
| publishDate | 2024-02-01 |
| publisher | Koya University |
| record_format | Article |
| series | ARO-The Scientific Journal of Koya University |
| spelling | doaj.art-2d221eb381674424aaf9710218c376222024-02-16T21:59:28ZengKoya UniversityARO-The Scientific Journal of Koya University2410-93552307-549X2024-02-0112110.14500/aro.11471Synthesis of Some novel Azomethine Oxide Derived from Aromatic Oximes and their Anti-microbial StudiesJihad H. Mohammed0Akram N. Qaddo1Nabaz A. Muhammad 2Faeza B. Omar3Department of Chemistry, Faculty of Science, Soran University, Kurdistan Region – F.R. IraqDepartment of Chemistry, Education College for Girls, University of Mosul – F.R. IraqDepartment of Chemistry, Faculty of Science, Soran University, Kurdistan Region – F.R. IraqDepartment of Biology, Faculty of Science, Soran University, Kurdistan Region – F.R. Iraq The organic compound category known as azomethine oxides has garnered significant attention due to its potential for bioactive and pharmacological effects, as well as its role in organic syntheses. Existing literature offers various methods for producing derivatives of these compounds. This study, in particular, concentrates on the creation of several aromatic oximes through the reduction of corresponding aldehydes. Furthermore, these oximes are employed in the generation of new azomethine oxides through a condensation reaction with selected aldehydes. The molecular structure of the synthesized azomethine oxides is determined using techniques such as Fourier-transform infrared spectroscopy, 1H-NMR, and 13C-NMR. Finally, the antimicrobial effectiveness of these compounds was assessed against Escherichia coli (gram-negative bacteria), Staphylococcus aureus (gram-positive bacteria), and Candida albicans (fungus). The synthesized compounds were obtained with high purity and yielded excellent results. Furthermore, the data demonstrates that these azomethine oxides exhibit significant antimicrobial activity when compared to standard drugs. https://aro.koyauniversity.org/index.php/aro/article/view/1471Aromatic oximesAzomethine-N-oxideBiological activityCondensation reaction |
| spellingShingle | Jihad H. Mohammed Akram N. Qaddo Nabaz A. Muhammad Faeza B. Omar Synthesis of Some novel Azomethine Oxide Derived from Aromatic Oximes and their Anti-microbial Studies ARO-The Scientific Journal of Koya University Aromatic oximes Azomethine-N-oxide Biological activity Condensation reaction |
| title | Synthesis of Some novel Azomethine Oxide Derived from Aromatic Oximes and their Anti-microbial Studies |
| title_full | Synthesis of Some novel Azomethine Oxide Derived from Aromatic Oximes and their Anti-microbial Studies |
| title_fullStr | Synthesis of Some novel Azomethine Oxide Derived from Aromatic Oximes and their Anti-microbial Studies |
| title_full_unstemmed | Synthesis of Some novel Azomethine Oxide Derived from Aromatic Oximes and their Anti-microbial Studies |
| title_short | Synthesis of Some novel Azomethine Oxide Derived from Aromatic Oximes and their Anti-microbial Studies |
| title_sort | synthesis of some novel azomethine oxide derived from aromatic oximes and their anti microbial studies |
| topic | Aromatic oximes Azomethine-N-oxide Biological activity Condensation reaction |
| url | https://aro.koyauniversity.org/index.php/aro/article/view/1471 |
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