Reversal of Alpha-Synuclein Fibrillization by Protein Disulfide Isomerase

Reversal of Alpha-Synuclein Fibrillization by Protein Disulfide Isomerase

Aggregates of α-synuclein contribute to the etiology of Parkinson’s Disease. Protein disulfide isomerase (PDI), a chaperone and oxidoreductase, blocks the aggregation of α-synuclein. An S-nitrosylated form of PDI that cannot function as a chaperone is associated with elevated levels of aggregated α-...

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Bibliographic Details
Main Authors: Albert Serrano, Xin Qiao, Jason O. Matos, Lauren Farley, Lucia Cilenti, Bo Chen, Suren A. Tatulian, Ken Teter
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
amyloid
chaperone
disaggregase
ERp57
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00726/full

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