Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. To characterize the clinic...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Uberlândia
2019-07-01
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| Series: | Bioscience Journal |
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| Online Access: | https://seer-dev.ufu.br/index.php/biosciencejournal/article/view/36227 |
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| author | Wanessa da Silva Peres Bezerra Marcos Antonio Ferreira Júnior Isabelle Campos de Azevedo Mayk Penze Cardoso Andreia Insabralde de Queiroz Cardoso Oleci Pereira Frota Maria Lúcia Ivo Vanessa Giavarotti Taboza Flores Elenilda de Andrade Pereira Gonçalves |
| author_facet | Wanessa da Silva Peres Bezerra Marcos Antonio Ferreira Júnior Isabelle Campos de Azevedo Mayk Penze Cardoso Andreia Insabralde de Queiroz Cardoso Oleci Pereira Frota Maria Lúcia Ivo Vanessa Giavarotti Taboza Flores Elenilda de Andrade Pereira Gonçalves |
| author_sort | Wanessa da Silva Peres Bezerra |
| collection | DOAJ |
| description |
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. To characterize the clinical and epidemiological profile of children and adolescents submitted to HSCT at a referral service in the state of Rio Grande do Norte. This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. The records analyzed showed a little majority of male patients (51.42%) and 60.00% of these men were students and 71.42% lived in the state of the Rio Grande do Norte. According to the clinical characteristics, 34.3% of the patients had Acute Lymphoblastic Leukemia and 25.71% had Acute Myeloid Leukemia as the main diagnosis. Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. Septsis was the most frequent cause of death (60%). The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. These data are similar to studies conducted in North America, Europe and Asia.
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| first_indexed | 2024-12-14T19:35:50Z |
| format | Article |
| id | doaj.art-2d2543ea68254abda2a8fee3f66f3a95 |
| institution | Directory Open Access Journal |
| issn | 1981-3163 |
| language | English |
| last_indexed | 2024-12-14T19:35:50Z |
| publishDate | 2019-07-01 |
| publisher | Universidade Federal de Uberlândia |
| record_format | Article |
| series | Bioscience Journal |
| spelling | doaj.art-2d2543ea68254abda2a8fee3f66f3a952022-12-21T22:49:54ZengUniversidade Federal de UberlândiaBioscience Journal1981-31632019-07-01355Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantationWanessa da Silva Peres Bezerra0Marcos Antonio Ferreira Júnior1Isabelle Campos de Azevedo2Mayk Penze Cardoso3Andreia Insabralde de Queiroz Cardoso4Oleci Pereira Frota5Maria Lúcia Ivo6Vanessa Giavarotti Taboza Flores7Elenilda de Andrade Pereira Gonçalves8Universidade Federal de Mato Grosso do SulUniversidade Federal de Mato Grosso do SulUniversidade Federal do Rio Grande do NorteUniversidade Federal de Mato Grosso do SulUniversidade Federal de Mato Grosso do SulUniversidade Federal de Mato Grosso do SulUniversidade Federal de Mato Grosso do SulUniversidade Federal de Mato Grosso do SulUniversidade Católica Dom Bosco The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. To characterize the clinical and epidemiological profile of children and adolescents submitted to HSCT at a referral service in the state of Rio Grande do Norte. This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. The records analyzed showed a little majority of male patients (51.42%) and 60.00% of these men were students and 71.42% lived in the state of the Rio Grande do Norte. According to the clinical characteristics, 34.3% of the patients had Acute Lymphoblastic Leukemia and 25.71% had Acute Myeloid Leukemia as the main diagnosis. Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. Septsis was the most frequent cause of death (60%). The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. These data are similar to studies conducted in North America, Europe and Asia. https://seer-dev.ufu.br/index.php/biosciencejournal/article/view/36227Hematopoietic Stem Cell TransplantationBone Marrow TransplantationChildAdolescentEpidemiology |
| spellingShingle | Wanessa da Silva Peres Bezerra Marcos Antonio Ferreira Júnior Isabelle Campos de Azevedo Mayk Penze Cardoso Andreia Insabralde de Queiroz Cardoso Oleci Pereira Frota Maria Lúcia Ivo Vanessa Giavarotti Taboza Flores Elenilda de Andrade Pereira Gonçalves Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation Bioscience Journal Hematopoietic Stem Cell Transplantation Bone Marrow Transplantation Child Adolescent Epidemiology |
| title | Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
| title_full | Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
| title_fullStr | Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
| title_full_unstemmed | Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
| title_short | Clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
| title_sort | clinical and epidemiological profile of children and adolescents submitted to the hematopoietic cell transplantation |
| topic | Hematopoietic Stem Cell Transplantation Bone Marrow Transplantation Child Adolescent Epidemiology |
| url | https://seer-dev.ufu.br/index.php/biosciencejournal/article/view/36227 |
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