A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices
Abstract Glaucoma drainage devices (GDDs) are prosthetic-treatment devices for treating primary open-angle glaucoma. Despite their effectiveness in reducing intraocular pressures (IOP), endothelial cell damage (ECD) is a commonly known side-effect. There have been different hypotheses regarding the...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-50491-9 |
| _version_ | 1797275058700288000 |
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| author | Nicol Basson Chao-Hong Surachai Peng Patrick Geoghegan Tshilidzi van der Lecq David Steven Susan Williams An Eng Lim Wei Hua Ho |
| author_facet | Nicol Basson Chao-Hong Surachai Peng Patrick Geoghegan Tshilidzi van der Lecq David Steven Susan Williams An Eng Lim Wei Hua Ho |
| author_sort | Nicol Basson |
| collection | DOAJ |
| description | Abstract Glaucoma drainage devices (GDDs) are prosthetic-treatment devices for treating primary open-angle glaucoma. Despite their effectiveness in reducing intraocular pressures (IOP), endothelial cell damage (ECD) is a commonly known side-effect. There have been different hypotheses regarding the reasons for ECD with one being an induced increase in shear on the corneal wall. A computational fluid dynamics (CFD) model was used to investigate this hypothesis in silico. The Ahmed Glaucoma Valve (AGV) was selected as the subject of this study using an idealised 3D model of the anterior chamber with insertion angles and positions that are commonly used in clinical practice. It was found that a tube-cornea distance of 1.27 mm or greater does not result in a wall shear stress (WSS) above the limit where ECD could occur. Similarly, a tube-cornea angle of 45° or more was shown to be preferable. It was also found that the ECD region has an irregular shape, and the aqueous humour flow fluctuates at certain insertion angles and positions. This study shows that pathological amounts of WSS may occur as a result of certain GDD placements. Hence, it is imperative to consider the associated fluid force interactions when performing the GDD insertion procedure. |
| first_indexed | 2024-03-07T15:08:53Z |
| format | Article |
| id | doaj.art-2d275e4d3e8449d6aaadc6e7469b9e5f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:08:53Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2d275e4d3e8449d6aaadc6e7469b9e5f2024-03-05T18:46:45ZengNature PortfolioScientific Reports2045-23222024-02-011411810.1038/s41598-023-50491-9A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devicesNicol Basson0Chao-Hong Surachai Peng1Patrick Geoghegan2Tshilidzi van der Lecq3David Steven4Susan Williams5An Eng Lim6Wei Hua Ho7Department of Thermal & Fluid Engineering, Faculty of Engineering Technology, University of TwenteMechanical, Industrial & Aeronautical Engineering, Faculty of Engineering & the Built Environment, University of Witwatersrand, JohannesburgDepartment of Mechanical, Biomedical and Design Engineering, School of Engineering & Technology, College of Engineering and Physical Sciences, Aston UniversityDivision of Ophthalmology, Faculty of Health Sciences, University of Cape TownDivision of Ophthalmology, Faculty of Health Sciences, University of Cape TownDivision of Ophthalmology, School of Clinical Medicine, Faculty of Health Sciences, University of the WitwatersrandBioprocessing Technology Institute, Agency for Science, Technology and ResearchMechanical, Industrial & Aeronautical Engineering, Faculty of Engineering & the Built Environment, University of Witwatersrand, JohannesburgAbstract Glaucoma drainage devices (GDDs) are prosthetic-treatment devices for treating primary open-angle glaucoma. Despite their effectiveness in reducing intraocular pressures (IOP), endothelial cell damage (ECD) is a commonly known side-effect. There have been different hypotheses regarding the reasons for ECD with one being an induced increase in shear on the corneal wall. A computational fluid dynamics (CFD) model was used to investigate this hypothesis in silico. The Ahmed Glaucoma Valve (AGV) was selected as the subject of this study using an idealised 3D model of the anterior chamber with insertion angles and positions that are commonly used in clinical practice. It was found that a tube-cornea distance of 1.27 mm or greater does not result in a wall shear stress (WSS) above the limit where ECD could occur. Similarly, a tube-cornea angle of 45° or more was shown to be preferable. It was also found that the ECD region has an irregular shape, and the aqueous humour flow fluctuates at certain insertion angles and positions. This study shows that pathological amounts of WSS may occur as a result of certain GDD placements. Hence, it is imperative to consider the associated fluid force interactions when performing the GDD insertion procedure.https://doi.org/10.1038/s41598-023-50491-9 |
| spellingShingle | Nicol Basson Chao-Hong Surachai Peng Patrick Geoghegan Tshilidzi van der Lecq David Steven Susan Williams An Eng Lim Wei Hua Ho A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices Scientific Reports |
| title | A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices |
| title_full | A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices |
| title_fullStr | A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices |
| title_full_unstemmed | A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices |
| title_short | A computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices |
| title_sort | computational fluid dynamics investigation of endothelial cell damage from glaucoma drainage devices |
| url | https://doi.org/10.1038/s41598-023-50491-9 |
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