Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults
BackgroundAging is associated with a higher prevalence of sarcopenia, sarcopenic obesity (SO), and increased arterial stiffening, with possible detrimental effects on morbidity and mortality. The aim of this study was to assess the relationships between sarcopenia, SO, and different indexes of arter...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1272854/full |
| _version_ | 1797321014292512768 |
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| author | Francesco Fantin Anna Giani Gisella Manzato Annachiara Zampieri Gabriele Comellato Silvia Urbani Elena Zoico Gloria Mazzali Mauro Zamboni |
| author_facet | Francesco Fantin Anna Giani Gisella Manzato Annachiara Zampieri Gabriele Comellato Silvia Urbani Elena Zoico Gloria Mazzali Mauro Zamboni |
| author_sort | Francesco Fantin |
| collection | DOAJ |
| description | BackgroundAging is associated with a higher prevalence of sarcopenia, sarcopenic obesity (SO), and increased arterial stiffening, with possible detrimental effects on morbidity and mortality. The aim of this study was to assess the relationships between sarcopenia, SO, and different indexes of arterial stiffness in older adults.MethodsA total of 77 hospitalized patients (mean age 78.68 ± 9.65 years) were evaluated, obtaining anthropometric variables, biochemical samples, handgrip test, and body composition assessment. Arterial stiffness was evaluated by measuring both carotid-femoral pulse wave velocity (cfPWV), a proxy for central stiffness, and cardio-ankle vascular index (CAVI), as well as considering peripheral arteries. The population was sorted into four subgroups: obese, sarcopenic, SO, and controls.ResultsThe highest CAVI (11.31 ± 2.58) was found in sarcopenic patients. SO had the highest value of cfPWV (15.18 ± 8.44 m/s), even after adjustment for significant covariates. In multiple regressions, SO diagnosis resulted as a significant predictor of cfPWV (p = 0.03, R2 = 0.20), and sarcopenia diagnosis resulted as a predictor of CAVI (p = 0.042, R2 = 0.12).ConclusionsIn conclusion, a positive correlation is found between sarcopenia, SO, and arterial stiffness among older subjects. In particular, greater central arterial stiffness is associated with SO, outlining a remarkable effect on the cardiovascular risk profile. |
| first_indexed | 2024-03-08T04:51:23Z |
| format | Article |
| id | doaj.art-2d2940e4f4c249c5afe1fb368506b613 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-08T04:51:23Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-2d2940e4f4c249c5afe1fb368506b6132024-02-08T04:53:44ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-02-011110.3389/fcvm.2024.12728541272854Sarcopenia, sarcopenic obesity, and arterial stiffness among older adultsFrancesco Fantin0Anna Giani1Gisella Manzato2Annachiara Zampieri3Gabriele Comellato4Silvia Urbani5Elena Zoico6Gloria Mazzali7Mauro Zamboni8Section of Geriatric Medicine, Department of Medicine, University of Verona, Verona, ItalySection of Geriatric Medicine, Department of Surgery, Dentistry, Pediatric and Gynecology, University of Verona, Verona, ItalySection of Geriatric Medicine, Department of Surgery, Dentistry, Pediatric and Gynecology, University of Verona, Verona, ItalySection of Geriatric Medicine, Department of Surgery, Dentistry, Pediatric and Gynecology, University of Verona, Verona, ItalySection of Geriatric Medicine, Department of Surgery, Dentistry, Pediatric and Gynecology, University of Verona, Verona, ItalySection of Geriatric Medicine, Department of Surgery, Dentistry, Pediatric and Gynecology, University of Verona, Verona, ItalySection of Geriatric Medicine, Department of Surgery, Dentistry, Pediatric and Gynecology, University of Verona, Verona, ItalySection of Geriatric Medicine, Department of Medicine, University of Verona, Verona, ItalySection of Geriatric Medicine, Department of Surgery, Dentistry, Pediatric and Gynecology, University of Verona, Verona, ItalyBackgroundAging is associated with a higher prevalence of sarcopenia, sarcopenic obesity (SO), and increased arterial stiffening, with possible detrimental effects on morbidity and mortality. The aim of this study was to assess the relationships between sarcopenia, SO, and different indexes of arterial stiffness in older adults.MethodsA total of 77 hospitalized patients (mean age 78.68 ± 9.65 years) were evaluated, obtaining anthropometric variables, biochemical samples, handgrip test, and body composition assessment. Arterial stiffness was evaluated by measuring both carotid-femoral pulse wave velocity (cfPWV), a proxy for central stiffness, and cardio-ankle vascular index (CAVI), as well as considering peripheral arteries. The population was sorted into four subgroups: obese, sarcopenic, SO, and controls.ResultsThe highest CAVI (11.31 ± 2.58) was found in sarcopenic patients. SO had the highest value of cfPWV (15.18 ± 8.44 m/s), even after adjustment for significant covariates. In multiple regressions, SO diagnosis resulted as a significant predictor of cfPWV (p = 0.03, R2 = 0.20), and sarcopenia diagnosis resulted as a predictor of CAVI (p = 0.042, R2 = 0.12).ConclusionsIn conclusion, a positive correlation is found between sarcopenia, SO, and arterial stiffness among older subjects. In particular, greater central arterial stiffness is associated with SO, outlining a remarkable effect on the cardiovascular risk profile.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1272854/fullarterial stiffnesssarcopeniaobesitysarcopenic obesitycardio-ankle vascular indexpulse wave velocity |
| spellingShingle | Francesco Fantin Anna Giani Gisella Manzato Annachiara Zampieri Gabriele Comellato Silvia Urbani Elena Zoico Gloria Mazzali Mauro Zamboni Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults Frontiers in Cardiovascular Medicine arterial stiffness sarcopenia obesity sarcopenic obesity cardio-ankle vascular index pulse wave velocity |
| title | Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults |
| title_full | Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults |
| title_fullStr | Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults |
| title_full_unstemmed | Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults |
| title_short | Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults |
| title_sort | sarcopenia sarcopenic obesity and arterial stiffness among older adults |
| topic | arterial stiffness sarcopenia obesity sarcopenic obesity cardio-ankle vascular index pulse wave velocity |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1272854/full |
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