The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg
Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly causing ocular and urogenital infections that affect millions of people worldwide and which can lead to blindness or sterility. They reside and multiply intracellularly within a membrane-bound vacuolar compartment,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2019-08-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/2019a-bugalhao-microbial-cell/ |
| _version_ | 1826532022314598400 |
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| author | Joana N. Bugalhão Luís Jaime Mota |
| author_facet | Joana N. Bugalhão Luís Jaime Mota |
| author_sort | Joana N. Bugalhão |
| collection | DOAJ |
| description | Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly causing ocular and urogenital infections that affect millions of people worldwide and which can lead to blindness or sterility. They reside and multiply intracellularly within a membrane-bound vacuolar compartment, known as inclusion, and are characterized by a developmental cycle involving two morphologically and physiologically distinct chlamydial forms. Completion of the developmental cycle involves the secretion of > 70 C. trachomatis proteins that function in the host cell cytoplasm and nucleus, in the inclusion membrane and lumen, and in the extracellular milieu. These proteins can, for example, interfere with the host cell cytoskeleton, vesicular and non-vesicular transport, metabolism, and immune signalling. Generally, this promotes C. trachomatis invasion into, and escape from, host cells, the acquisition of nutrients by the chlamydiae, and evasion of cell-autonomous, humoral and cellular innate immunity. Here, we present an in-depth review on the current knowledge and outstanding questions about these C. trachomatis secreted proteins. |
| first_indexed | 2024-12-12T01:58:56Z |
| format | Article |
| id | doaj.art-2d2a90cfa9cc444ca086aac92a9947c5 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2025-03-14T01:44:37Z |
| publishDate | 2019-08-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-2d2a90cfa9cc444ca086aac92a9947c52025-03-12T13:46:42ZengShared Science Publishers OGMicrobial Cell2311-26382019-08-016941444910.15698/mic2019.09.691The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the icebergJoana N. Bugalhão0Luís Jaime Mota1UCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Caparica, Portugal.UCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Caparica, Portugal.Chlamydia trachomatis serovars are obligate intracellular bacterial pathogens mainly causing ocular and urogenital infections that affect millions of people worldwide and which can lead to blindness or sterility. They reside and multiply intracellularly within a membrane-bound vacuolar compartment, known as inclusion, and are characterized by a developmental cycle involving two morphologically and physiologically distinct chlamydial forms. Completion of the developmental cycle involves the secretion of > 70 C. trachomatis proteins that function in the host cell cytoplasm and nucleus, in the inclusion membrane and lumen, and in the extracellular milieu. These proteins can, for example, interfere with the host cell cytoskeleton, vesicular and non-vesicular transport, metabolism, and immune signalling. Generally, this promotes C. trachomatis invasion into, and escape from, host cells, the acquisition of nutrients by the chlamydiae, and evasion of cell-autonomous, humoral and cellular innate immunity. Here, we present an in-depth review on the current knowledge and outstanding questions about these C. trachomatis secreted proteins.http://microbialcell.com/researcharticles/2019a-bugalhao-microbial-cell/host-pathogen interactionsChlamydia trachomatisprotein secretiontype III secretioneffectors |
| spellingShingle | Joana N. Bugalhão Luís Jaime Mota The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg Microbial Cell host-pathogen interactions Chlamydia trachomatis protein secretion type III secretion effectors |
| title | The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg |
| title_full | The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg |
| title_fullStr | The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg |
| title_full_unstemmed | The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg |
| title_short | The multiple functions of the numerous Chlamydia trachomatis secreted proteins: the tip of the iceberg |
| title_sort | multiple functions of the numerous chlamydia trachomatis secreted proteins the tip of the iceberg |
| topic | host-pathogen interactions Chlamydia trachomatis protein secretion type III secretion effectors |
| url | http://microbialcell.com/researcharticles/2019a-bugalhao-microbial-cell/ |
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