Effects of ketamine, midazolam and methadone, combined with local anesthesia, in cats undergoing orchiectomy
Different anesthetic combinations are used for orchiectomy in cats. This study aimed to evaluate the anesthetic and cardiopulmonary effects on the physiological variables of ketamine (10 mg/kg), midazolam (0.2 mg/kg) and methadone (0.3 mg/kg), combined with local anesthesia, in cats undergoing orchi...
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| Format: | Article |
| Language: | English |
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Universidade Federal Rural do Semi-Árido (UFERSA)
2023-06-01
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| Series: | Acta Veterinaria Brasilica |
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| Online Access: | https://periodicos.ufersa.edu.br/acta/article/view/11392 |
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| author | Virgínia Conceição Tavares Lima Anna Julia Rodrigues Peixoto Ana Carolina de Souza Campos Maria Eduarda dos Santos Lopes Fernandes Viviane Horta Gomes Cássia Maria Molinaro Coelho |
| author_facet | Virgínia Conceição Tavares Lima Anna Julia Rodrigues Peixoto Ana Carolina de Souza Campos Maria Eduarda dos Santos Lopes Fernandes Viviane Horta Gomes Cássia Maria Molinaro Coelho |
| author_sort | Virgínia Conceição Tavares Lima |
| collection | DOAJ |
| description | Different anesthetic combinations are used for orchiectomy in cats. This study aimed to evaluate the anesthetic and cardiopulmonary effects on the physiological variables of ketamine (10 mg/kg), midazolam (0.2 mg/kg) and methadone (0.3 mg/kg), combined with local anesthesia, in cats undergoing orchiectomy (n = 19 cats). The time for lateral recumbency, degree of sedation, muscle relaxation and nociception were recorded preoperatively. The propofol rescue dose was recorded. The time to head up and quality of recovery were evaluated postoperatively. The time for lateral recumbency was 5 ± 2 minutes. Fifteen minutes after the administration of the ketamine-midazolam-methadone combination, a greater sedative effect, muscle relaxation and less response to noxious stimulation were observed. Propofol was administered to twelve cats under local anesthesia, at a total dose of 1.5 ± 0.8 mg/kg. Surgery was started 28 ± 5 minutes after the administration of ketamine-midazolam-methadone combination. There were no differences in the physiological variables evaluated over the other evaluation times (p > 0.05). The recovery quality scores were adequate, and the time to head up was 51 ± 10 minutes. Under the conditions of this study, the ketamine-midazolam-methadone combination did not allow local anesthesia for orchiectomy. Many cats required propofol rescue prior to surgery. This combination promoted minimal changes in physiological variables and prolonged anesthetic recovery. |
| first_indexed | 2024-03-13T01:39:35Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1981-5484 |
| language | English |
| last_indexed | 2024-03-13T01:39:35Z |
| publishDate | 2023-06-01 |
| publisher | Universidade Federal Rural do Semi-Árido (UFERSA) |
| record_format | Article |
| series | Acta Veterinaria Brasilica |
| spelling | doaj.art-2d2accfb5a94444cb51d53d7ea9a0f0f2023-07-03T14:44:03ZengUniversidade Federal Rural do Semi-Árido (UFERSA)Acta Veterinaria Brasilica1981-54842023-06-01171707410.21708/avb.2023.17.1.11392Effects of ketamine, midazolam and methadone, combined with local anesthesia, in cats undergoing orchiectomyVirgínia Conceição Tavares Lima0https://orcid.org/0000-0002-3535-5085Anna Julia Rodrigues Peixoto1https://orcid.org/0000-0002-4861-7726Ana Carolina de Souza Campos2https://orcid.org/0000-0001-5420-8438Maria Eduarda dos Santos Lopes Fernandes3https://orcid.org/0000-0003-1414-2475Viviane Horta Gomes4https://orcid.org/0000-0001-8283-4022Cássia Maria Molinaro Coelho5https://orcid.org/0000-0003-1205-8413Universidade Federal Rural do Rio de Janeiro (UFRRJ), Departamento de Medicina e Cirurgia Veterinária, Seropédica, 23.897-000 Rio de Janeiro, Brasil.Universidade Federal Rural do Rio de Janeiro (UFRRJ), Departamento de Medicina e Cirurgia Veterinária, Seropédica, 23.897-000 Rio de Janeiro, Brasil.Universidade Federal Rural do Rio de Janeiro (UFRRJ), Departamento de Medicina e Cirurgia Veterinária, Seropédica, 23.897-000 Rio de Janeiro, Brasil.Universidade Federal Rural do Rio de Janeiro (UFRRJ), Departamento de Medicina e Cirurgia Veterinária, Seropédica, 23.897-000 Rio de Janeiro, Brasil.Universidade Federal Rural do Rio de Janeiro (UFRRJ), Departamento de Medicina e Cirurgia Veterinária, Seropédica, 23.897-000 Rio de Janeiro, Brasil.Universidade Federal Rural do Rio de Janeiro (UFRRJ), Departamento de Medicina e Cirurgia Veterinária, Seropédica, 23.897-000 Rio de Janeiro, Brasil.Different anesthetic combinations are used for orchiectomy in cats. This study aimed to evaluate the anesthetic and cardiopulmonary effects on the physiological variables of ketamine (10 mg/kg), midazolam (0.2 mg/kg) and methadone (0.3 mg/kg), combined with local anesthesia, in cats undergoing orchiectomy (n = 19 cats). The time for lateral recumbency, degree of sedation, muscle relaxation and nociception were recorded preoperatively. The propofol rescue dose was recorded. The time to head up and quality of recovery were evaluated postoperatively. The time for lateral recumbency was 5 ± 2 minutes. Fifteen minutes after the administration of the ketamine-midazolam-methadone combination, a greater sedative effect, muscle relaxation and less response to noxious stimulation were observed. Propofol was administered to twelve cats under local anesthesia, at a total dose of 1.5 ± 0.8 mg/kg. Surgery was started 28 ± 5 minutes after the administration of ketamine-midazolam-methadone combination. There were no differences in the physiological variables evaluated over the other evaluation times (p > 0.05). The recovery quality scores were adequate, and the time to head up was 51 ± 10 minutes. Under the conditions of this study, the ketamine-midazolam-methadone combination did not allow local anesthesia for orchiectomy. Many cats required propofol rescue prior to surgery. This combination promoted minimal changes in physiological variables and prolonged anesthetic recovery.https://periodicos.ufersa.edu.br/acta/article/view/11392anesthetic recoverybenzodiazepinesdissociative anesthesiafelineopioids |
| spellingShingle | Virgínia Conceição Tavares Lima Anna Julia Rodrigues Peixoto Ana Carolina de Souza Campos Maria Eduarda dos Santos Lopes Fernandes Viviane Horta Gomes Cássia Maria Molinaro Coelho Effects of ketamine, midazolam and methadone, combined with local anesthesia, in cats undergoing orchiectomy Acta Veterinaria Brasilica anesthetic recovery benzodiazepines dissociative anesthesia feline opioids |
| title | Effects of ketamine, midazolam and methadone, combined with local anesthesia, in cats undergoing orchiectomy |
| title_full | Effects of ketamine, midazolam and methadone, combined with local anesthesia, in cats undergoing orchiectomy |
| title_fullStr | Effects of ketamine, midazolam and methadone, combined with local anesthesia, in cats undergoing orchiectomy |
| title_full_unstemmed | Effects of ketamine, midazolam and methadone, combined with local anesthesia, in cats undergoing orchiectomy |
| title_short | Effects of ketamine, midazolam and methadone, combined with local anesthesia, in cats undergoing orchiectomy |
| title_sort | effects of ketamine midazolam and methadone combined with local anesthesia in cats undergoing orchiectomy |
| topic | anesthetic recovery benzodiazepines dissociative anesthesia feline opioids |
| url | https://periodicos.ufersa.edu.br/acta/article/view/11392 |
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