Exosomes in the Diagnosis and Treatment of Renal Cell Cancer
Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer originating from renal tubular epithelial cells, with clear cell RCC comprising approximately 80% of cases. The primary treatment modalities for RCC are surgery and targeted therapy, albeit with suboptimal efficacies. Despite pro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14356 |
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| author | Stergios Boussios Perry Devo Iain C. A. Goodall Konstantinos Sirlantzis Aruni Ghose Sayali D. Shinde Vasileios Papadopoulos Elisabet Sanchez Elie Rassy Saak V. Ovsepian |
| author_facet | Stergios Boussios Perry Devo Iain C. A. Goodall Konstantinos Sirlantzis Aruni Ghose Sayali D. Shinde Vasileios Papadopoulos Elisabet Sanchez Elie Rassy Saak V. Ovsepian |
| author_sort | Stergios Boussios |
| collection | DOAJ |
| description | Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer originating from renal tubular epithelial cells, with clear cell RCC comprising approximately 80% of cases. The primary treatment modalities for RCC are surgery and targeted therapy, albeit with suboptimal efficacies. Despite progress in RCC research, significant challenges persist, including advanced distant metastasis, delayed diagnosis, and drug resistance. Growing evidence suggests that extracellular vesicles (EVs) play a pivotal role in multiple aspects of RCC, including tumorigenesis, metastasis, immune evasion, and drug response. These membrane-bound vesicles are released into the extracellular environment by nearly all cell types and are capable of transferring various bioactive molecules, including RNA, DNA, proteins, and lipids, aiding intercellular communication. The molecular cargo carried by EVs renders them an attractive resource for biomarker identification, while their multifarious role in the RCC offers opportunities for diagnosis and targeted interventions, including EV-based therapies. As the most versatile type of EVs, exosomes have attracted much attention as nanocarriers of biologicals, with multi-range signaling effects. Despite the growing interest in exosomes, there is currently no widely accepted consensus on their subtypes and properties. The emerging heterogeneity of exosomes presents both methodological challenges and exciting opportunities for diagnostic and clinical interventions. This article reviews the characteristics and functions of exosomes, with a particular reference to the recent advances in their application to the diagnosis and treatment of RCC. |
| first_indexed | 2024-03-10T22:38:55Z |
| format | Article |
| id | doaj.art-2d2c39f722cb46dc88ce543625abcf65 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:38:55Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2d2c39f722cb46dc88ce543625abcf652023-11-19T11:11:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181435610.3390/ijms241814356Exosomes in the Diagnosis and Treatment of Renal Cell CancerStergios Boussios0Perry Devo1Iain C. A. Goodall2Konstantinos Sirlantzis3Aruni Ghose4Sayali D. Shinde5Vasileios Papadopoulos6Elisabet Sanchez7Elie Rassy8Saak V. Ovsepian9Department of Medical Oncology, Medway NHS Foundation Trust, Gillingham ME7 5NY, UKSchool of Sciences, Faculty of Engineering and Science, University of Greenwich, Chatham Maritime ME4 4TB, UKSchool of Sciences, Faculty of Engineering and Science, University of Greenwich, Chatham Maritime ME4 4TB, UKSchool of Engineering, Technology and Design, Canterbury Christ Church University, Canterbury CT1 1QU, UKDepartment of Medical Oncology, Medway NHS Foundation Trust, Gillingham ME7 5NY, UKCentre for Tumour Biology, Barts Cancer Institute, Cancer Research UK Barts Centre, Queen Mary University of London, London EC1M 6BQ, UKDepartment of Urology, Medway NHS Foundation Trust, Gillingham ME7 5NY, UKDepartment of Medical Oncology, Medway NHS Foundation Trust, Gillingham ME7 5NY, UKDepartment of Medical Oncology, Gustave Roussy Institut, 94805 Villejuif, FranceSchool of Sciences, Faculty of Engineering and Science, University of Greenwich, Chatham Maritime ME4 4TB, UKRenal cell carcinoma (RCC) is the most prevalent type of kidney cancer originating from renal tubular epithelial cells, with clear cell RCC comprising approximately 80% of cases. The primary treatment modalities for RCC are surgery and targeted therapy, albeit with suboptimal efficacies. Despite progress in RCC research, significant challenges persist, including advanced distant metastasis, delayed diagnosis, and drug resistance. Growing evidence suggests that extracellular vesicles (EVs) play a pivotal role in multiple aspects of RCC, including tumorigenesis, metastasis, immune evasion, and drug response. These membrane-bound vesicles are released into the extracellular environment by nearly all cell types and are capable of transferring various bioactive molecules, including RNA, DNA, proteins, and lipids, aiding intercellular communication. The molecular cargo carried by EVs renders them an attractive resource for biomarker identification, while their multifarious role in the RCC offers opportunities for diagnosis and targeted interventions, including EV-based therapies. As the most versatile type of EVs, exosomes have attracted much attention as nanocarriers of biologicals, with multi-range signaling effects. Despite the growing interest in exosomes, there is currently no widely accepted consensus on their subtypes and properties. The emerging heterogeneity of exosomes presents both methodological challenges and exciting opportunities for diagnostic and clinical interventions. This article reviews the characteristics and functions of exosomes, with a particular reference to the recent advances in their application to the diagnosis and treatment of RCC.https://www.mdpi.com/1422-0067/24/18/14356renal cell cancerexosomestumor microenvironmentmRNAmiRNAtumor drug resistance |
| spellingShingle | Stergios Boussios Perry Devo Iain C. A. Goodall Konstantinos Sirlantzis Aruni Ghose Sayali D. Shinde Vasileios Papadopoulos Elisabet Sanchez Elie Rassy Saak V. Ovsepian Exosomes in the Diagnosis and Treatment of Renal Cell Cancer International Journal of Molecular Sciences renal cell cancer exosomes tumor microenvironment mRNA miRNA tumor drug resistance |
| title | Exosomes in the Diagnosis and Treatment of Renal Cell Cancer |
| title_full | Exosomes in the Diagnosis and Treatment of Renal Cell Cancer |
| title_fullStr | Exosomes in the Diagnosis and Treatment of Renal Cell Cancer |
| title_full_unstemmed | Exosomes in the Diagnosis and Treatment of Renal Cell Cancer |
| title_short | Exosomes in the Diagnosis and Treatment of Renal Cell Cancer |
| title_sort | exosomes in the diagnosis and treatment of renal cell cancer |
| topic | renal cell cancer exosomes tumor microenvironment mRNA miRNA tumor drug resistance |
| url | https://www.mdpi.com/1422-0067/24/18/14356 |
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