Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status
Abstract Aims Heart failure (HF) is a common cause of morbidity and mortality, related to a broad range of sociodemographic, lifestyle, cardiometabolic, and comorbidity risk factors, which may differ according to the presence of atherosclerotic cardiovascular disease (ASCVD). We assessed the associa...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.14521 |
| _version_ | 1797449194022109184 |
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| author | Luke P. Dawson Melinda J. Carrington Tilahun Haregu Shane Nanayakkara Garry Jennings Anthony Dart Dion Stub David Kaye |
| author_facet | Luke P. Dawson Melinda J. Carrington Tilahun Haregu Shane Nanayakkara Garry Jennings Anthony Dart Dion Stub David Kaye |
| author_sort | Luke P. Dawson |
| collection | DOAJ |
| description | Abstract Aims Heart failure (HF) is a common cause of morbidity and mortality, related to a broad range of sociodemographic, lifestyle, cardiometabolic, and comorbidity risk factors, which may differ according to the presence of atherosclerotic cardiovascular disease (ASCVD). We assessed the association between incident HF with baseline status across these domains, overall and separated according to ASCVD status. Methods and results We included 5758 participants from the Baker Biobank cohort without HF at baseline enrolled between January 2000 and December 2011. The primary endpoint was incident HF, defined as hospital admission or HF‐related death, determined through linkage with state‐wide administrative databases (median follow‐up 12.2 years). Regression models were fitted adjusted for sociodemographic variables, alcohol intake, smoking status, measures of adiposity, cardiometabolic profile measures, and individual comorbidities. During 65 987 person‐years (median age 59 years, 38% women), incident HF occurred among 784 participants (13.6%) overall. Rates of incident HF were higher among patients with ASCVD (624/1929, 32.4%) compared with those without ASCVD (160/3829, 4.2%). Incident HF was associated with age, socio‐economic status, alcohol intake, smoking status, body mass index (BMI), waist circumference, waist–hip ratio, systolic blood pressure (SBP), and low‐ and high‐density lipoprotein cholesterol (LDL‐C and HDL‐C), with non‐linear relationships observed for age, alcohol intake, BMI, waist circumference, waist–hip ratio, SBP, LDL‐C, and HDL‐C. Risk factors for incident HF were largely consistent regardless of ASCVD status, although diabetes status had a greater association with incident HF among patients without ASCVD. Conclusions Incident HF is associated with a broad range of baseline sociodemographic, lifestyle, cardiometabolic, and comorbidity factors, which are mostly consistent regardless of ASCVD status. These data could be useful in efforts towards developing risk prediction models that can be used in patients with ASCVD. |
| first_indexed | 2024-03-09T14:22:26Z |
| format | Article |
| id | doaj.art-2d2f71e14ba44887bc696f9b0157f68d |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-03-09T14:22:26Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-2d2f71e14ba44887bc696f9b0157f68d2023-11-28T09:37:49ZengWileyESC Heart Failure2055-58222023-12-011063398340910.1002/ehf2.14521Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease statusLuke P. Dawson0Melinda J. Carrington1Tilahun Haregu2Shane Nanayakkara3Garry Jennings4Anthony Dart5Dion Stub6David Kaye7Department of Cardiology The Alfred Hospital Melbourne Victoria AustraliaBaker Heart and Diabetes Institute 55 Commercial Rd, Prahran Melbourne Victoria AustraliaDepartment of Cardiology The Alfred Hospital Melbourne Victoria AustraliaDepartment of Cardiology The Alfred Hospital Melbourne Victoria AustraliaBaker Heart and Diabetes Institute 55 Commercial Rd, Prahran Melbourne Victoria AustraliaDepartment of Cardiology The Alfred Hospital Melbourne Victoria AustraliaDepartment of Cardiology The Alfred Hospital Melbourne Victoria AustraliaDepartment of Cardiology The Alfred Hospital Melbourne Victoria AustraliaAbstract Aims Heart failure (HF) is a common cause of morbidity and mortality, related to a broad range of sociodemographic, lifestyle, cardiometabolic, and comorbidity risk factors, which may differ according to the presence of atherosclerotic cardiovascular disease (ASCVD). We assessed the association between incident HF with baseline status across these domains, overall and separated according to ASCVD status. Methods and results We included 5758 participants from the Baker Biobank cohort without HF at baseline enrolled between January 2000 and December 2011. The primary endpoint was incident HF, defined as hospital admission or HF‐related death, determined through linkage with state‐wide administrative databases (median follow‐up 12.2 years). Regression models were fitted adjusted for sociodemographic variables, alcohol intake, smoking status, measures of adiposity, cardiometabolic profile measures, and individual comorbidities. During 65 987 person‐years (median age 59 years, 38% women), incident HF occurred among 784 participants (13.6%) overall. Rates of incident HF were higher among patients with ASCVD (624/1929, 32.4%) compared with those without ASCVD (160/3829, 4.2%). Incident HF was associated with age, socio‐economic status, alcohol intake, smoking status, body mass index (BMI), waist circumference, waist–hip ratio, systolic blood pressure (SBP), and low‐ and high‐density lipoprotein cholesterol (LDL‐C and HDL‐C), with non‐linear relationships observed for age, alcohol intake, BMI, waist circumference, waist–hip ratio, SBP, LDL‐C, and HDL‐C. Risk factors for incident HF were largely consistent regardless of ASCVD status, although diabetes status had a greater association with incident HF among patients without ASCVD. Conclusions Incident HF is associated with a broad range of baseline sociodemographic, lifestyle, cardiometabolic, and comorbidity factors, which are mostly consistent regardless of ASCVD status. These data could be useful in efforts towards developing risk prediction models that can be used in patients with ASCVD.https://doi.org/10.1002/ehf2.14521Risk factorsHeart failureCardiometabolic profileLifestyleSocio‐economic statusAtherosclerotic cardiovascular disease |
| spellingShingle | Luke P. Dawson Melinda J. Carrington Tilahun Haregu Shane Nanayakkara Garry Jennings Anthony Dart Dion Stub David Kaye Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status ESC Heart Failure Risk factors Heart failure Cardiometabolic profile Lifestyle Socio‐economic status Atherosclerotic cardiovascular disease |
| title | Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status |
| title_full | Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status |
| title_fullStr | Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status |
| title_full_unstemmed | Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status |
| title_short | Differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status |
| title_sort | differences in predictors of incident heart failure according to atherosclerotic cardiovascular disease status |
| topic | Risk factors Heart failure Cardiometabolic profile Lifestyle Socio‐economic status Atherosclerotic cardiovascular disease |
| url | https://doi.org/10.1002/ehf2.14521 |
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