Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype
Background: Cognitive deficits are common in multiple sclerosis (MS) and affect patients at all stages of the disease, regardless of phenotype. Aims: This literature review focuses the cognitive deficits observed in secondary progressive MS (SPMS). It is mainly based on studies that compared the fre...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/2/183 |
| _version_ | 1797482189984628736 |
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| author | Bruno Brochet Pierre Clavelou Gilles Defer Jérôme De Seze Céline Louapre Eloi Magnin Aurélie Ruet Catherine Thomas-Anterion Patrick Vermersch |
| author_facet | Bruno Brochet Pierre Clavelou Gilles Defer Jérôme De Seze Céline Louapre Eloi Magnin Aurélie Ruet Catherine Thomas-Anterion Patrick Vermersch |
| author_sort | Bruno Brochet |
| collection | DOAJ |
| description | Background: Cognitive deficits are common in multiple sclerosis (MS) and affect patients at all stages of the disease, regardless of phenotype. Aims: This literature review focuses the cognitive deficits observed in secondary progressive MS (SPMS). It is mainly based on studies that compared the frequency and main characteristics of cognitive deficits in SPMS with other phenotypes. Methods: A bibliographic search was carried out using the PubMed database with the following keywords: multiple sclerosis, secondary-progressive, cognition. Results: Thirteen studies were initially selected that were published in English, reporting the neuropsychological data of a sample of at least 30 patients with SPMS, comparing them with patients with other phenotypes. Studies suggest that there is an association between the duration of the disease and the frequency and extent of the cognitive disorders. Studies also showed that the SP form is associated with an increased frequency of cognitive impairment and with an increased severity as compared to relapsing-remitting MS (RRMS). Compared to RRMS, progressive forms of MS are associated with more severe impairment in certain cognitive areas, such as episodic verbal memory, information processing speed, working memory, or verbal fluency. Two studies showed that cognitive performances decline overtime in SPMS. Conclusion: Cognitive disorders are more frequent and more severe in the SP form than in relapsing course of MS. The profile of cognitive impairment encountered in the SP form also appears to be different from those found in the other phenotypes. |
| first_indexed | 2024-03-09T22:27:45Z |
| format | Article |
| id | doaj.art-2d31837f18ee4d378e9091b8a5c4a5bc |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T22:27:45Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-2d31837f18ee4d378e9091b8a5c4a5bc2023-11-23T19:02:55ZengMDPI AGBrain Sciences2076-34252022-01-0112218310.3390/brainsci12020183Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive PhenotypeBruno Brochet0Pierre Clavelou1Gilles Defer2Jérôme De Seze3Céline Louapre4Eloi Magnin5Aurélie Ruet6Catherine Thomas-Anterion7Patrick Vermersch8Neurocentre Magendie Inserm U 1215, Université de Bordeaux, 146 rue de Léo Saignat, 33077 Bordeaux, FranceCRC-SEP, Hôpital Gabriel Montpied, CHU de Clermont-Ferrand, 58 Rue Montalembert, 63003 Clermont-Ferrand, FranceCRC-SEP, Service de Neurologie, CHU de Caen, Avenue de la côte de Nacre, 14033 Caen, FranceCRC-SEP, CHU Strasbourg, Hôpital Hautepierre, 1 Avenue Molière, 67098 Strasbourg, FranceSorbonne University, Paris Brain Institute—ICM, Assistance Publique Hôpitaux de Paris, Inserm, CNRS, Hôpital de la Pitié Salpêtrière, CIC Neurosciences, 75013, Paris, FranceService de Neurologie, Hôpital Jean Minoz, 1-3 Boulevard Alexandre Fleming, 25000 Besançon, FranceNeurocentre Magendie, INSERM U 1215, Université de Bordeaux, Service de Neurologie, CHU de Bordeaux, Hôpital Pellegrin, Place Amélie Raba Léon, 33076 Bordeaux, FranceCentre Médical, 75 Rue Bataille, 69008 Lyon, FranceInserm U1172—Lille Neuroscience et Cognition, Université de Lille, CRCR SEP, CHU Lille, FHU Precise, 59000 Lille, FranceBackground: Cognitive deficits are common in multiple sclerosis (MS) and affect patients at all stages of the disease, regardless of phenotype. Aims: This literature review focuses the cognitive deficits observed in secondary progressive MS (SPMS). It is mainly based on studies that compared the frequency and main characteristics of cognitive deficits in SPMS with other phenotypes. Methods: A bibliographic search was carried out using the PubMed database with the following keywords: multiple sclerosis, secondary-progressive, cognition. Results: Thirteen studies were initially selected that were published in English, reporting the neuropsychological data of a sample of at least 30 patients with SPMS, comparing them with patients with other phenotypes. Studies suggest that there is an association between the duration of the disease and the frequency and extent of the cognitive disorders. Studies also showed that the SP form is associated with an increased frequency of cognitive impairment and with an increased severity as compared to relapsing-remitting MS (RRMS). Compared to RRMS, progressive forms of MS are associated with more severe impairment in certain cognitive areas, such as episodic verbal memory, information processing speed, working memory, or verbal fluency. Two studies showed that cognitive performances decline overtime in SPMS. Conclusion: Cognitive disorders are more frequent and more severe in the SP form than in relapsing course of MS. The profile of cognitive impairment encountered in the SP form also appears to be different from those found in the other phenotypes.https://www.mdpi.com/2076-3425/12/2/183multiple sclerosiscognitionsecondary progressive MSneuropsychology |
| spellingShingle | Bruno Brochet Pierre Clavelou Gilles Defer Jérôme De Seze Céline Louapre Eloi Magnin Aurélie Ruet Catherine Thomas-Anterion Patrick Vermersch Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype Brain Sciences multiple sclerosis cognition secondary progressive MS neuropsychology |
| title | Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype |
| title_full | Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype |
| title_fullStr | Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype |
| title_full_unstemmed | Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype |
| title_short | Cognitive Impairment in Secondary Progressive Multiple Sclerosis: Effect of Disease Duration, Age, and Progressive Phenotype |
| title_sort | cognitive impairment in secondary progressive multiple sclerosis effect of disease duration age and progressive phenotype |
| topic | multiple sclerosis cognition secondary progressive MS neuropsychology |
| url | https://www.mdpi.com/2076-3425/12/2/183 |
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