Neuroendocrine regulation of female aggression
Classically the neurobiology of aggression has been studied exclusively in males. Thus, females have been considered mildly aggressive except during lactation. Interestingly, recent studies in rodents and humans have revealed that non-lactating females can show exacerbated and pathological aggressio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.957114/full |
| _version_ | 1798037763978690560 |
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| author | Vinícius Elias de Moura Oliveira Julie Bakker |
| author_facet | Vinícius Elias de Moura Oliveira Julie Bakker |
| author_sort | Vinícius Elias de Moura Oliveira |
| collection | DOAJ |
| description | Classically the neurobiology of aggression has been studied exclusively in males. Thus, females have been considered mildly aggressive except during lactation. Interestingly, recent studies in rodents and humans have revealed that non-lactating females can show exacerbated and pathological aggression similarly to males. This review provides an overview of recent findings on the neuroendocrine mechanisms regulating aggressive behavior in females. In particular, the focus will be on novel rodent models of exaggerated aggression established in non-lactating females. Among the neuromodulatory systems influencing female aggression, special attention has been given to sex-steroids and sex-steroid-sensitive neuronal populations (i.e., the core nuclei of the neural pathway of aggression) as well as to the neuropeptides oxytocin and vasopressin which are major players in the regulation of social behaviors. |
| first_indexed | 2024-04-11T21:31:00Z |
| format | Article |
| id | doaj.art-2d3459c21fe9477eac3665f93e695213 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T21:31:00Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2d3459c21fe9477eac3665f93e6952132022-12-22T04:01:59ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-08-011310.3389/fendo.2022.957114957114Neuroendocrine regulation of female aggressionVinícius Elias de Moura OliveiraJulie BakkerClassically the neurobiology of aggression has been studied exclusively in males. Thus, females have been considered mildly aggressive except during lactation. Interestingly, recent studies in rodents and humans have revealed that non-lactating females can show exacerbated and pathological aggression similarly to males. This review provides an overview of recent findings on the neuroendocrine mechanisms regulating aggressive behavior in females. In particular, the focus will be on novel rodent models of exaggerated aggression established in non-lactating females. Among the neuromodulatory systems influencing female aggression, special attention has been given to sex-steroids and sex-steroid-sensitive neuronal populations (i.e., the core nuclei of the neural pathway of aggression) as well as to the neuropeptides oxytocin and vasopressin which are major players in the regulation of social behaviors.https://www.frontiersin.org/articles/10.3389/fendo.2022.957114/fullaggressive behaviorsocial behaviorestrogen receptorsoxytocin (OXT)vasopressin (AVP)corticosterone |
| spellingShingle | Vinícius Elias de Moura Oliveira Julie Bakker Neuroendocrine regulation of female aggression Frontiers in Endocrinology aggressive behavior social behavior estrogen receptors oxytocin (OXT) vasopressin (AVP) corticosterone |
| title | Neuroendocrine regulation of female aggression |
| title_full | Neuroendocrine regulation of female aggression |
| title_fullStr | Neuroendocrine regulation of female aggression |
| title_full_unstemmed | Neuroendocrine regulation of female aggression |
| title_short | Neuroendocrine regulation of female aggression |
| title_sort | neuroendocrine regulation of female aggression |
| topic | aggressive behavior social behavior estrogen receptors oxytocin (OXT) vasopressin (AVP) corticosterone |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.957114/full |
| work_keys_str_mv | AT viniciuseliasdemouraoliveira neuroendocrineregulationoffemaleaggression AT juliebakker neuroendocrineregulationoffemaleaggression |