Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech
Speech processing is built upon encoding by the auditory nerve and brainstem, yet we know very little about how these processes unfold in specific subcortical structures. These structures are deep and respond quickly, making them difficult to study during ongoing speech. Recent techniques have begun...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-02-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/62329 |
| _version_ | 1811180591811395584 |
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| author | Melissa J Polonenko Ross K Maddox |
| author_facet | Melissa J Polonenko Ross K Maddox |
| author_sort | Melissa J Polonenko |
| collection | DOAJ |
| description | Speech processing is built upon encoding by the auditory nerve and brainstem, yet we know very little about how these processes unfold in specific subcortical structures. These structures are deep and respond quickly, making them difficult to study during ongoing speech. Recent techniques have begun to address this problem, but yield temporally broad responses with consequently ambiguous neural origins. Here, we describe a method that pairs re-synthesized ‘peaky’ speech with deconvolution analysis of electroencephalography recordings. We show that in adults with normal hearing the method quickly yields robust responses whose component waves reflect activity from distinct subcortical structures spanning auditory nerve to rostral brainstem. We further demonstrate the versatility of peaky speech by simultaneously measuring bilateral and ear-specific responses across different frequency bands and discuss the important practical considerations such as talker choice. The peaky speech method holds promise as a tool for investigating speech encoding and processing, and for clinical applications. |
| first_indexed | 2024-04-11T09:05:53Z |
| format | Article |
| id | doaj.art-2d359fd11f0444409d21798da1d9526a |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:05:53Z |
| publishDate | 2021-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-2d359fd11f0444409d21798da1d9526a2022-12-22T04:32:39ZengeLife Sciences Publications LtdeLife2050-084X2021-02-011010.7554/eLife.62329Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speechMelissa J Polonenko0https://orcid.org/0000-0003-1914-6117Ross K Maddox1https://orcid.org/0000-0003-2668-0238Department of Neuroscience, University of Rochester, Rochester, United States; Del Monte Institute for Neuroscience, University of Rochester, Rochester, United States; Center for Visual Science, University of Rochester, Rochester, United StatesDepartment of Neuroscience, University of Rochester, Rochester, United States; Del Monte Institute for Neuroscience, University of Rochester, Rochester, United States; Center for Visual Science, University of Rochester, Rochester, United States; Department of Biomedical Engineering, University of Rochester, Rochester, United StatesSpeech processing is built upon encoding by the auditory nerve and brainstem, yet we know very little about how these processes unfold in specific subcortical structures. These structures are deep and respond quickly, making them difficult to study during ongoing speech. Recent techniques have begun to address this problem, but yield temporally broad responses with consequently ambiguous neural origins. Here, we describe a method that pairs re-synthesized ‘peaky’ speech with deconvolution analysis of electroencephalography recordings. We show that in adults with normal hearing the method quickly yields robust responses whose component waves reflect activity from distinct subcortical structures spanning auditory nerve to rostral brainstem. We further demonstrate the versatility of peaky speech by simultaneously measuring bilateral and ear-specific responses across different frequency bands and discuss the important practical considerations such as talker choice. The peaky speech method holds promise as a tool for investigating speech encoding and processing, and for clinical applications.https://elifesciences.org/articles/62329speechauditory brainstem responseevoked potentialselectroencephalographyassessmentEEG |
| spellingShingle | Melissa J Polonenko Ross K Maddox Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech eLife speech auditory brainstem response evoked potentials electroencephalography assessment EEG |
| title | Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech |
| title_full | Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech |
| title_fullStr | Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech |
| title_full_unstemmed | Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech |
| title_short | Exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech |
| title_sort | exposing distinct subcortical components of the auditory brainstem response evoked by continuous naturalistic speech |
| topic | speech auditory brainstem response evoked potentials electroencephalography assessment EEG |
| url | https://elifesciences.org/articles/62329 |
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