Evolution and developmental expression of the sodium–iodide symporter (NIS, slc5a5) gene family: Implications for perchlorate toxicology

Evolution and developmental expression of the sodium–iodide symporter (NIS, slc5a5) gene family: Implications for perchlorate toxicology

Abstract The vertebrate sodium–iodide symporter (NIS or SLC5A5) transports iodide into the thyroid follicular cells that synthesize thyroid hormone. The SLC5A protein family includes transporters of vitamins, minerals, and nutrients. Disruption of SLC5A5 function by perchlorate, a pervasive environm...

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Bibliographic Details
Main Authors: Ann M. Petersen, Clayton M. Small, Yi‐Lin Yan, Catherine Wilson, Peter Batzel, Ruth A. Bremiller, C. Loren Buck, Frank A. vonHippel, William A. Cresko, John H. Postlethwait
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Evolutionary Applications
Subjects:
gene evolution
NIS
perchlorate
slc5a5
stickleback
thyroid
Online Access:https://doi.org/10.1111/eva.13424

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