The Study on Acute and Subacute Toxicity and Sarcoma-180 Anti-cancer Effects of Vermilionum
Background & Methods : In order to measure the acute and subacute toxicity of Vermilionum and it's anti-cancer effects, Sarcoma-180 abdominal cancer cells were injected intravenously. The following results were obtained after measuring the survival rate, toxicity of the NK cells, and IL-2 p...
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| Format: | Article |
| Language: | English |
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Korean Pharmacopuncture Institute
2003-12-01
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| Series: | Journal of Pharmacopuncture |
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| Online Access: | http://dx.doi.org/10.3831/KPI.2003.6.3.039 |
| Summary: | Background & Methods : In order to measure the acute and subacute toxicity of Vermilionum and it's anti-cancer effects, Sarcoma-180 abdominal cancer cells were injected intravenously. The following results were obtained after measuring the survival rate, toxicity of the NK cells, and IL-2 productivity.
Results : 1. It was impossible to measure LD50 value in the acute toxicity test and no toxic effects were witnessed in the clinical observation.
2. No significant differences were shown in the weight changes between the experiment groups and the control group in the acute toxicity test.
3. No peculiar toxic effects were shown in the subacute toxicity test and the weight changes were insignificant between the experiment groups and the control group.
4. In measuring the survival rate after inducing abdominal cancer by Sarcoma-180, the experiment groups showed increased of 9,52% compared to the control group.
5. In measuring the activity of NK cells, no significant changes were shown between the experiment groups and the control group.
6. In measuring the productivity of IL-2, significant reduction was shown in the experiment groups compared to the normal group, but no significance was witnessed compared to the control group. |
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| ISSN: | 2093-6966 2234-6856 |