Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity
Increasing evidence supports a link between maternal prenatal cannabis use and altered neural and physiological development of the child. However, whether cannabis use relates to altered human brain development prior to birth, and specifically, whether maternal prenatal cannabis use relates to conne...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929321000906 |
| _version_ | 1818584572118433792 |
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| author | Moriah E. Thomason Ava C. Palopoli Nicki N. Jariwala Denise M. Werchan Alan Chen Samrachana Adhikari Claudia Espinoza-Heredia Natalie H. Brito Christopher J. Trentacosta |
| author_facet | Moriah E. Thomason Ava C. Palopoli Nicki N. Jariwala Denise M. Werchan Alan Chen Samrachana Adhikari Claudia Espinoza-Heredia Natalie H. Brito Christopher J. Trentacosta |
| author_sort | Moriah E. Thomason |
| collection | DOAJ |
| description | Increasing evidence supports a link between maternal prenatal cannabis use and altered neural and physiological development of the child. However, whether cannabis use relates to altered human brain development prior to birth, and specifically, whether maternal prenatal cannabis use relates to connectivity of fetal functional brain systems, remains an open question. The major objective of this study was to identify whether maternal prenatal cannabis exposure (PCE) is associated with variation in human brain hippocampal functional connectivity prior to birth. Prenatal drug toxicology and fetal fMRI data were available in a sample of 115 fetuses [43 % female; mean age 32.2 weeks (SD = 4.3)]. Voxelwise hippocampal connectivity analysis in a subset of age and sex-matched fetuses revealed that PCE was associated with alterations in fetal dorsolateral, medial and superior frontal, insula, anterior temporal, and posterior cingulate connectivity. Classification of group differences by age 5 outcomes suggest that compared to the non-PCE group, the PCE group is more likely to have increased connectivity to regions associated with less favorable outcomes and to have decreased connectivity to regions associated with more favorable outcomes. This is preliminary evidence that altered fetal neural connectome may contribute to neurobehavioral vulnerability observed in children exposed to cannabis in utero. |
| first_indexed | 2024-12-16T08:23:18Z |
| format | Article |
| id | doaj.art-2d3b2964dda64915ac01d163dbf6b3e8 |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-12-16T08:23:18Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-2d3b2964dda64915ac01d163dbf6b3e82022-12-21T22:38:04ZengElsevierDevelopmental Cognitive Neuroscience1878-92932021-10-0151101000Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivityMoriah E. Thomason0Ava C. Palopoli1Nicki N. Jariwala2Denise M. Werchan3Alan Chen4Samrachana Adhikari5Claudia Espinoza-Heredia6Natalie H. Brito7Christopher J. Trentacosta8Department of Child and Adolescent Psychiatry, New York University Medical Center, New York, NY, USA; Department of Population Health, New York University Medical Center, New York, NY, USA; Neuroscience Institute, New York University Medical Center, New York, NY, USA; Corresponding author at: Child and Adolescent Psychiatry, NYU Langone Health, One Park Ave, 7th Floor, New York, NY 10016, USA.Department of Psychology, Wayne State University, Detroit, MI, USADepartment of Child and Adolescent Psychiatry, New York University Medical Center, New York, NY, USADepartment of Child and Adolescent Psychiatry, New York University Medical Center, New York, NY, USADepartment of Population Health, New York University Medical Center, New York, NY, USADepartment of Population Health, New York University Medical Center, New York, NY, USADepartment of Child and Adolescent Psychiatry, New York University Medical Center, New York, NY, USADepartment of Applied Psychology, New York University, New York, NY, USADepartment of Psychology, Wayne State University, Detroit, MI, USAIncreasing evidence supports a link between maternal prenatal cannabis use and altered neural and physiological development of the child. However, whether cannabis use relates to altered human brain development prior to birth, and specifically, whether maternal prenatal cannabis use relates to connectivity of fetal functional brain systems, remains an open question. The major objective of this study was to identify whether maternal prenatal cannabis exposure (PCE) is associated with variation in human brain hippocampal functional connectivity prior to birth. Prenatal drug toxicology and fetal fMRI data were available in a sample of 115 fetuses [43 % female; mean age 32.2 weeks (SD = 4.3)]. Voxelwise hippocampal connectivity analysis in a subset of age and sex-matched fetuses revealed that PCE was associated with alterations in fetal dorsolateral, medial and superior frontal, insula, anterior temporal, and posterior cingulate connectivity. Classification of group differences by age 5 outcomes suggest that compared to the non-PCE group, the PCE group is more likely to have increased connectivity to regions associated with less favorable outcomes and to have decreased connectivity to regions associated with more favorable outcomes. This is preliminary evidence that altered fetal neural connectome may contribute to neurobehavioral vulnerability observed in children exposed to cannabis in utero.http://www.sciencedirect.com/science/article/pii/S1878929321000906BrainCannabisFetalHippocampusPrenatalResting-state |
| spellingShingle | Moriah E. Thomason Ava C. Palopoli Nicki N. Jariwala Denise M. Werchan Alan Chen Samrachana Adhikari Claudia Espinoza-Heredia Natalie H. Brito Christopher J. Trentacosta Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity Developmental Cognitive Neuroscience Brain Cannabis Fetal Hippocampus Prenatal Resting-state |
| title | Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity |
| title_full | Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity |
| title_fullStr | Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity |
| title_full_unstemmed | Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity |
| title_short | Miswiring the brain: Human prenatal Δ9-tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity |
| title_sort | miswiring the brain human prenatal δ9 tetrahydrocannabinol use associated with altered fetal hippocampal brain network connectivity |
| topic | Brain Cannabis Fetal Hippocampus Prenatal Resting-state |
| url | http://www.sciencedirect.com/science/article/pii/S1878929321000906 |
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