Expressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical Significance
<p><strong>Background and Objective: </strong>The role of (Human Papilloma Virus) HPV in cancer of certain anatomical location, such as cervix, has been widely recognized. The present study was conducted to explore the association between HPV 16-E6 protein and esophageal squamous c...
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| Format: | Article |
| Language: | English |
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College of Medical Sciences
2015-07-01
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| Series: | Journal of College of Medical Sciences-Nepal |
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| Online Access: | http://nepjol.info/index.php/JCMSN/article/view/12970 |
| _version_ | 1811260972106514432 |
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| author | Xing Zhao Rajina Sahi Yu-Yang Zhao Ju Wang Chun-Hui Li |
| author_facet | Xing Zhao Rajina Sahi Yu-Yang Zhao Ju Wang Chun-Hui Li |
| author_sort | Xing Zhao |
| collection | DOAJ |
| description | <p><strong>Background and Objective: </strong>The role of (Human Papilloma Virus) HPV in cancer of certain anatomical location, such as cervix, has been widely recognized. The present study was conducted to explore the association between HPV 16-E6 protein and esophageal squamous cell carcinoma.</p> <p><strong>Methods: </strong>SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.</p> <p><strong>Results: </strong>The expression of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had significant correlation with invasive depth (P<0.05), but not with patient age, lymph node metastasis, tumor size (P>0.05).</p> <p><strong>Conclusion: </strong>HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.</p><p>DOI: <a href="http://dx.doi.org/10.3126/jcmsn.v10i4.12970">http://dx.doi.org/10.3126/jcmsn.v10i4.12970</a></p> <p>JCMS Nepal 2014; 10(4):1-5</p><p> </p> |
| first_indexed | 2024-04-12T18:55:32Z |
| format | Article |
| id | doaj.art-2d3cc4473f154c44a783f169c02a6400 |
| institution | Directory Open Access Journal |
| issn | 2091-0657 2091-0673 |
| language | English |
| last_indexed | 2024-04-12T18:55:32Z |
| publishDate | 2015-07-01 |
| publisher | College of Medical Sciences |
| record_format | Article |
| series | Journal of College of Medical Sciences-Nepal |
| spelling | doaj.art-2d3cc4473f154c44a783f169c02a64002022-12-22T03:20:21ZengCollege of Medical SciencesJournal of College of Medical Sciences-Nepal2091-06572091-06732015-07-011041510.3126/jcmsn.v10i4.1297010164Expressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical SignificanceXing Zhao0Rajina Sahi1Yu-Yang Zhao2Ju Wang3Chun-Hui Li4Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei ProvinceBP Koirala Memorial Cancer Hospital, ChitwanAffiliated Hospital of Chengde Medical College, Chengde 067000, Hebei ProvinceAffiliated Hospital of Chengde Medical College, Chengde 067000, Hebei ProvinceAffiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province<p><strong>Background and Objective: </strong>The role of (Human Papilloma Virus) HPV in cancer of certain anatomical location, such as cervix, has been widely recognized. The present study was conducted to explore the association between HPV 16-E6 protein and esophageal squamous cell carcinoma.</p> <p><strong>Methods: </strong>SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.</p> <p><strong>Results: </strong>The expression of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had significant correlation with invasive depth (P<0.05), but not with patient age, lymph node metastasis, tumor size (P>0.05).</p> <p><strong>Conclusion: </strong>HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.</p><p>DOI: <a href="http://dx.doi.org/10.3126/jcmsn.v10i4.12970">http://dx.doi.org/10.3126/jcmsn.v10i4.12970</a></p> <p>JCMS Nepal 2014; 10(4):1-5</p><p> </p>http://nepjol.info/index.php/JCMSN/article/view/12970Esophageal carcinomaHPV 16-E6Immunohistochemistry |
| spellingShingle | Xing Zhao Rajina Sahi Yu-Yang Zhao Ju Wang Chun-Hui Li Expressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical Significance Journal of College of Medical Sciences-Nepal Esophageal carcinoma HPV 16-E6 Immunohistochemistry |
| title | Expressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical Significance |
| title_full | Expressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical Significance |
| title_fullStr | Expressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical Significance |
| title_full_unstemmed | Expressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical Significance |
| title_short | Expressions of HPV 16-E6 in Esophageal Carcinoma and its Clinical Significance |
| title_sort | expressions of hpv 16 e6 in esophageal carcinoma and its clinical significance |
| topic | Esophageal carcinoma HPV 16-E6 Immunohistochemistry |
| url | http://nepjol.info/index.php/JCMSN/article/view/12970 |
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