Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia–Reperfusion Injury by Activating Nrf2 Pathway
High intraocular pressure (IOP)-induced retinal ischemia leads to acute glaucoma, which is one of the leading causes of irreversible visual-field loss, characterized by loss of retinal ganglion cells (RGCs) and axonal injury in optic nerves (ONs). Oxidative stress and the inflammatory response play...
Main Authors: | Longxiang Sheng, Bingzheng Lu, Hui Chen, Yun Du, Chen Chen, Wei Cai, Yang Yang, Xuyan Tian, Zhaofeng Huang, Wei Chi, Suizhen Lin, Guangmei Yan, Wei Yin |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-05-01
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Series: | Marine Drugs |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-3397/17/5/267 |
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