Predictors of Fatal Pulmonary Haemorrhage in Dogs Affected by Leptospirosis Approaching Haemodialysis
A retrospective case control study, which aimed to evaluate potential clinical, laboratory and imaging predictors of fatal pulmonary haemorrhage in dogs with Leptospirosis submitted to haemodialysis. The study population was divided in two groups according to the presence (PH) or absence (nPH) of pu...
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MDPI AG
2021-02-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/8/2/25 |
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| author | Ilaria Lippi Caterina Puccinelli Francesca Perondi Gianila Ceccherini Alessio Pierini Veronica Marchetti Simonetta Citi |
| author_facet | Ilaria Lippi Caterina Puccinelli Francesca Perondi Gianila Ceccherini Alessio Pierini Veronica Marchetti Simonetta Citi |
| author_sort | Ilaria Lippi |
| collection | DOAJ |
| description | A retrospective case control study, which aimed to evaluate potential clinical, laboratory and imaging predictors of fatal pulmonary haemorrhage in dogs with Leptospirosis submitted to haemodialysis. The study population was divided in two groups according to the presence (PH) or absence (nPH) of pulmonary haemorrhage. A statistical comparison was performed at hospital admission for clinical (spontaneous bleeding, icterus, and respiratory distress), laboratory (serum creatinine, urea, phosphate, calcium, bicarbonate, bilirubin, AST, ALT, ALKP, GGT, total protein, albumin, glycaemia, sodium, potassium, CRP, RBC, HCT, HGB, WBC, PLT, PT, aPTT, fibrinogen), and pulmonary radiographic findings between the two groups of dogs. At hospital admission, dogs developing pulmonary haemorrhage were more likely to have respiratory distress (<i>p</i> = 0.002), severely elevated serum bilirubin (<i>p</i> = 0.002), AST (<i>p</i> = 0.04), ALT (<i>p</i> = 0.012), ALKP (<i>p</i> = 0.002), reduced serum glycaemia (<i>p</i> = 0.014), and thrombocytopenia (<i>p</i> = 0.04). Respiratory distress and elevated serum bilirubin (≥11.5 mg/dL) were independently associated with increased risk of pulmonary haemorrhage. In conclusion, the presence of respiratory distress at hospital admission is strongly associated (OR 40.9) with increased risk of pulmonary haemorrhage, even though no abnormalities are found at chest radiography. |
| first_indexed | 2024-03-09T05:07:49Z |
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| id | doaj.art-2d3d49cadf024f6dbf1527141e5d1f8d |
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| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T05:07:49Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-2d3d49cadf024f6dbf1527141e5d1f8d2023-12-03T12:52:15ZengMDPI AGVeterinary Sciences2306-73812021-02-01822510.3390/vetsci8020025Predictors of Fatal Pulmonary Haemorrhage in Dogs Affected by Leptospirosis Approaching HaemodialysisIlaria Lippi0Caterina Puccinelli1Francesca Perondi2Gianila Ceccherini3Alessio Pierini4Veronica Marchetti5Simonetta Citi6Department of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyOspedale Veterinario San Concordio, Via Savonarola 106/f, 55100 Lucca, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyDepartment of Veterinary Sciences, University of Pisa, Via Livornese Lato Monte, San Piero a Grado, 56122 Pisa, ItalyA retrospective case control study, which aimed to evaluate potential clinical, laboratory and imaging predictors of fatal pulmonary haemorrhage in dogs with Leptospirosis submitted to haemodialysis. The study population was divided in two groups according to the presence (PH) or absence (nPH) of pulmonary haemorrhage. A statistical comparison was performed at hospital admission for clinical (spontaneous bleeding, icterus, and respiratory distress), laboratory (serum creatinine, urea, phosphate, calcium, bicarbonate, bilirubin, AST, ALT, ALKP, GGT, total protein, albumin, glycaemia, sodium, potassium, CRP, RBC, HCT, HGB, WBC, PLT, PT, aPTT, fibrinogen), and pulmonary radiographic findings between the two groups of dogs. At hospital admission, dogs developing pulmonary haemorrhage were more likely to have respiratory distress (<i>p</i> = 0.002), severely elevated serum bilirubin (<i>p</i> = 0.002), AST (<i>p</i> = 0.04), ALT (<i>p</i> = 0.012), ALKP (<i>p</i> = 0.002), reduced serum glycaemia (<i>p</i> = 0.014), and thrombocytopenia (<i>p</i> = 0.04). Respiratory distress and elevated serum bilirubin (≥11.5 mg/dL) were independently associated with increased risk of pulmonary haemorrhage. In conclusion, the presence of respiratory distress at hospital admission is strongly associated (OR 40.9) with increased risk of pulmonary haemorrhage, even though no abnormalities are found at chest radiography.https://www.mdpi.com/2306-7381/8/2/25pulmonary haemorrhagedogLeptospirosishaemodialysispredictors |
| spellingShingle | Ilaria Lippi Caterina Puccinelli Francesca Perondi Gianila Ceccherini Alessio Pierini Veronica Marchetti Simonetta Citi Predictors of Fatal Pulmonary Haemorrhage in Dogs Affected by Leptospirosis Approaching Haemodialysis Veterinary Sciences pulmonary haemorrhage dog Leptospirosis haemodialysis predictors |
| title | Predictors of Fatal Pulmonary Haemorrhage in Dogs Affected by Leptospirosis Approaching Haemodialysis |
| title_full | Predictors of Fatal Pulmonary Haemorrhage in Dogs Affected by Leptospirosis Approaching Haemodialysis |
| title_fullStr | Predictors of Fatal Pulmonary Haemorrhage in Dogs Affected by Leptospirosis Approaching Haemodialysis |
| title_full_unstemmed | Predictors of Fatal Pulmonary Haemorrhage in Dogs Affected by Leptospirosis Approaching Haemodialysis |
| title_short | Predictors of Fatal Pulmonary Haemorrhage in Dogs Affected by Leptospirosis Approaching Haemodialysis |
| title_sort | predictors of fatal pulmonary haemorrhage in dogs affected by leptospirosis approaching haemodialysis |
| topic | pulmonary haemorrhage dog Leptospirosis haemodialysis predictors |
| url | https://www.mdpi.com/2306-7381/8/2/25 |
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