Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response
The purpose of this review is to describe antifungal therapeutic candidates in preclinical and clinical development derived from, or directly influenced by, the immune system, with a specific focus on antimicrobial peptides (AMP). Although the focus of this review is AMP with direct antimicrobial ef...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.02177/full |
| _version_ | 1818265771552276480 |
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| author | Derry K. Mercer Deborah A. O'Neil |
| author_facet | Derry K. Mercer Deborah A. O'Neil |
| author_sort | Derry K. Mercer |
| collection | DOAJ |
| description | The purpose of this review is to describe antifungal therapeutic candidates in preclinical and clinical development derived from, or directly influenced by, the immune system, with a specific focus on antimicrobial peptides (AMP). Although the focus of this review is AMP with direct antimicrobial effects on fungi, we will also discuss compounds with direct antifungal activity, including monoclonal antibodies (mAb), as well as immunomodulatory molecules that can enhance the immune response to fungal infection, including immunomodulatory AMP, vaccines, checkpoint inhibitors, interferon and colony stimulating factors as well as immune cell therapies. The focus of this manuscript will be a non-exhaustive review of antifungal compounds in preclinical and clinical development that are based on the principles of immunology and the authors acknowledge the incredible amount of in vitro and in vivo work that has been conducted to develop such therapeutic candidates. |
| first_indexed | 2024-12-12T19:56:06Z |
| format | Article |
| id | doaj.art-2d3d84dadfeb457b98185b1ff4ba99bc |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T19:56:06Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2d3d84dadfeb457b98185b1ff4ba99bc2022-12-22T00:13:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-09-011110.3389/fimmu.2020.02177567754Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune ResponseDerry K. MercerDeborah A. O'NeilThe purpose of this review is to describe antifungal therapeutic candidates in preclinical and clinical development derived from, or directly influenced by, the immune system, with a specific focus on antimicrobial peptides (AMP). Although the focus of this review is AMP with direct antimicrobial effects on fungi, we will also discuss compounds with direct antifungal activity, including monoclonal antibodies (mAb), as well as immunomodulatory molecules that can enhance the immune response to fungal infection, including immunomodulatory AMP, vaccines, checkpoint inhibitors, interferon and colony stimulating factors as well as immune cell therapies. The focus of this manuscript will be a non-exhaustive review of antifungal compounds in preclinical and clinical development that are based on the principles of immunology and the authors acknowledge the incredible amount of in vitro and in vivo work that has been conducted to develop such therapeutic candidates.https://www.frontiersin.org/article/10.3389/fimmu.2020.02177/fullantimicrobial peptidehost defence peptideinnate immunityantifungalimmunotherapeutics |
| spellingShingle | Derry K. Mercer Deborah A. O'Neil Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response Frontiers in Immunology antimicrobial peptide host defence peptide innate immunity antifungal immunotherapeutics |
| title | Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response |
| title_full | Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response |
| title_fullStr | Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response |
| title_full_unstemmed | Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response |
| title_short | Innate Inspiration: Antifungal Peptides and Other Immunotherapeutics From the Host Immune Response |
| title_sort | innate inspiration antifungal peptides and other immunotherapeutics from the host immune response |
| topic | antimicrobial peptide host defence peptide innate immunity antifungal immunotherapeutics |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.02177/full |
| work_keys_str_mv | AT derrykmercer innateinspirationantifungalpeptidesandotherimmunotherapeuticsfromthehostimmuneresponse AT deborahaoneil innateinspirationantifungalpeptidesandotherimmunotherapeuticsfromthehostimmuneresponse |