Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer
Abstract Background Esophageal cancer (EC) is the leading cause of cancer‐related mortality worldwide. The underlying genetic risk factors remain unclear. The association between gene growth hormone receptor (GHR) and phospholipase C epsilon 1 (PLCE1) polymorphisms and the EC risk were identified in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.1474 |
| _version_ | 1797300979694043136 |
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| author | Rong Wang Lining Si Derui Zhu Guoping Shen Qifu Long Yanli Zhao |
| author_facet | Rong Wang Lining Si Derui Zhu Guoping Shen Qifu Long Yanli Zhao |
| author_sort | Rong Wang |
| collection | DOAJ |
| description | Abstract Background Esophageal cancer (EC) is the leading cause of cancer‐related mortality worldwide. The underlying genetic risk factors remain unclear. The association between gene growth hormone receptor (GHR) and phospholipase C epsilon 1 (PLCE1) polymorphisms and the EC risk were identified in this study. Methods A total of 506 EC cases and 507 controls were included in this research. Two SNPs (rs6898743 of GHR and rs2274223 of PLCE1) were selected and genotyped. The associations between gene polymorphisms and the EC risk were assessed by logistic regression analysis. The databases RegulomeDB, GTEx, and UALCAN were used for functional annotations. Results In the allelic frequencies analysis, the rs6898743 of GHR was associated with decreased susceptibility of EC (OR = 0.83, 95% CI: 0.70–1.00, p = 0.049), while rs2274223 of PLCE1 was associated with increased 0.25‐fold EC risk (OR = 1.25, 95% CI: 1.02–1.53, p = 0.037). The “GC” genotype of rs6898743 was associated with a 0.24‐fold decreased risk of EC under co‐dominant model (OR = 0.76, 95% CI: 0.58–0.99, p = 0.046), and the “GA” genotype of rs2274223 was associated with increased EC risk under co‐dominant model (OR = 1.36, 95% CI: 1.04–1.77, p = 0.023). Using GTEx database, rs2274223 was found to be significant associated with increased PLCE1 expression (p = 4.1 × 10−7) in esophagus muscularis. The UALCAN database demonstrated that the GHR gene was under‐expressed in esophageal cancer tissues (p = 0.017). Conclusion The gene GHR and PLCE1 polymorphisms are associated with EC in the general population and the results need to be verified in future. |
| first_indexed | 2024-03-07T23:14:48Z |
| format | Article |
| id | doaj.art-2d3e6f6fd9604a08b66960af70561c18 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-03-07T23:14:48Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-2d3e6f6fd9604a08b66960af70561c182024-02-21T12:03:04ZengWileyMolecular Genetics & Genomic Medicine2324-92692020-10-01810n/an/a10.1002/mgg3.1474Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancerRong Wang0Lining Si1Derui Zhu2Guoping Shen3Qifu Long4Yanli Zhao5Medical college Qinghai University Xining Qinghai Province ChinaDepartment of Critical‐Care Medicine Affiliated Hospital of Qinghai University Xining Qinghai Province ChinaMedical college Qinghai University Xining Qinghai Province ChinaMedical college Qinghai University Xining Qinghai Province ChinaMedical college Qinghai University Xining Qinghai Province ChinaMedical college Qinghai University Xining Qinghai Province ChinaAbstract Background Esophageal cancer (EC) is the leading cause of cancer‐related mortality worldwide. The underlying genetic risk factors remain unclear. The association between gene growth hormone receptor (GHR) and phospholipase C epsilon 1 (PLCE1) polymorphisms and the EC risk were identified in this study. Methods A total of 506 EC cases and 507 controls were included in this research. Two SNPs (rs6898743 of GHR and rs2274223 of PLCE1) were selected and genotyped. The associations between gene polymorphisms and the EC risk were assessed by logistic regression analysis. The databases RegulomeDB, GTEx, and UALCAN were used for functional annotations. Results In the allelic frequencies analysis, the rs6898743 of GHR was associated with decreased susceptibility of EC (OR = 0.83, 95% CI: 0.70–1.00, p = 0.049), while rs2274223 of PLCE1 was associated with increased 0.25‐fold EC risk (OR = 1.25, 95% CI: 1.02–1.53, p = 0.037). The “GC” genotype of rs6898743 was associated with a 0.24‐fold decreased risk of EC under co‐dominant model (OR = 0.76, 95% CI: 0.58–0.99, p = 0.046), and the “GA” genotype of rs2274223 was associated with increased EC risk under co‐dominant model (OR = 1.36, 95% CI: 1.04–1.77, p = 0.023). Using GTEx database, rs2274223 was found to be significant associated with increased PLCE1 expression (p = 4.1 × 10−7) in esophagus muscularis. The UALCAN database demonstrated that the GHR gene was under‐expressed in esophageal cancer tissues (p = 0.017). Conclusion The gene GHR and PLCE1 polymorphisms are associated with EC in the general population and the results need to be verified in future.https://doi.org/10.1002/mgg3.1474esophageal cancergrowth hormone receptorphospholipase C epsilon 1single nucleotide polymorphisms |
| spellingShingle | Rong Wang Lining Si Derui Zhu Guoping Shen Qifu Long Yanli Zhao Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer Molecular Genetics & Genomic Medicine esophageal cancer growth hormone receptor phospholipase C epsilon 1 single nucleotide polymorphisms |
| title | Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer |
| title_full | Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer |
| title_fullStr | Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer |
| title_full_unstemmed | Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer |
| title_short | Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer |
| title_sort | genetic variants in ghr and plce1 genes are associated with susceptibility to esophageal cancer |
| topic | esophageal cancer growth hormone receptor phospholipase C epsilon 1 single nucleotide polymorphisms |
| url | https://doi.org/10.1002/mgg3.1474 |
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