Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network)
(1) Background: Obesity is an increasing challenge in the care of pregnant women. The aim of our study was to investigate whether obesity is an independent risk factor for severe maternal and neonatal outcomes in pregnant women with COVID-19. (2) Methods: Data from the COVID-19 Related Obstetric and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/6/2089 |
| _version_ | 1797611002423934976 |
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| author | Friederike Weschenfelder Janine Zöllkau Anna Schohe Ulrich Pecks Tanja Groten Ute Schaefer-Graf on behalf of CRONOS-Network |
| author_facet | Friederike Weschenfelder Janine Zöllkau Anna Schohe Ulrich Pecks Tanja Groten Ute Schaefer-Graf on behalf of CRONOS-Network |
| author_sort | Friederike Weschenfelder |
| collection | DOAJ |
| description | (1) Background: Obesity is an increasing challenge in the care of pregnant women. The aim of our study was to investigate whether obesity is an independent risk factor for severe maternal and neonatal outcomes in pregnant women with COVID-19. (2) Methods: Data from the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS), a prospective multicenter registry for SARS-CoV-2 positive pregnant women, was used to analyze the effect of obesity on selected individual and combined outcome parameters (3) Results: With 20.1%, the prevalence of obesity in the CRONOS registry exceeds the German background rate of 17.5%. Obese women showed significantly higher rates of GDM (20.4% vs. 7.6%; <i>p</i> < 0.001), hypertensive pregnancy disorders (6.2% vs. 2%; <i>p</i> = 0.004) and C-sections (50% vs. 34.5%; <i>p</i> < 0.001). BMI was revealed to be an individual risk factor for the severe combined pregnancy outcome (maternal death, stillbirth or preterm birth < 32 weeks) (OR 1.050, CI 1.005–1.097). (4) Conclusions: Maternal BMI is a predictor for the most severe outcome as maternal or neonatal death and preterm delivery <32 weeks of gestation. Unexpectedly, categorized obesity seems to have limited independent influence on the course and outcome of pregnancies with COVID infections. |
| first_indexed | 2024-03-11T06:22:49Z |
| format | Article |
| id | doaj.art-2d41c916d05f40f7a6a4f1411f56d23a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T06:22:49Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2d41c916d05f40f7a6a4f1411f56d23a2023-11-17T11:47:55ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126208910.3390/jcm12062089Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network)Friederike Weschenfelder0Janine Zöllkau1Anna Schohe2Ulrich Pecks3Tanja Groten4Ute Schaefer-Graf5on behalf of CRONOS-NetworkDepartment of Obstetrics, University Hospital Jena, 07747 Jena, GermanyDepartment of Obstetrics, University Hospital Jena, 07747 Jena, GermanyDepartment of Obstetrics and Gynecology, Berlin Center for Diabetes and Pregnancy, St. Joseph Hospital, 12101 Berlin, GermanyDepartment of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, 24105 Kiel, GermanyDepartment of Obstetrics, University Hospital Jena, 07747 Jena, GermanyDepartment of Obstetrics and Gynecology, Berlin Center for Diabetes and Pregnancy, St. Joseph Hospital, 12101 Berlin, Germany(1) Background: Obesity is an increasing challenge in the care of pregnant women. The aim of our study was to investigate whether obesity is an independent risk factor for severe maternal and neonatal outcomes in pregnant women with COVID-19. (2) Methods: Data from the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS), a prospective multicenter registry for SARS-CoV-2 positive pregnant women, was used to analyze the effect of obesity on selected individual and combined outcome parameters (3) Results: With 20.1%, the prevalence of obesity in the CRONOS registry exceeds the German background rate of 17.5%. Obese women showed significantly higher rates of GDM (20.4% vs. 7.6%; <i>p</i> < 0.001), hypertensive pregnancy disorders (6.2% vs. 2%; <i>p</i> = 0.004) and C-sections (50% vs. 34.5%; <i>p</i> < 0.001). BMI was revealed to be an individual risk factor for the severe combined pregnancy outcome (maternal death, stillbirth or preterm birth < 32 weeks) (OR 1.050, CI 1.005–1.097). (4) Conclusions: Maternal BMI is a predictor for the most severe outcome as maternal or neonatal death and preterm delivery <32 weeks of gestation. Unexpectedly, categorized obesity seems to have limited independent influence on the course and outcome of pregnancies with COVID infections.https://www.mdpi.com/2077-0383/12/6/2089obesityoverweightSARS-CoV-2COVIDcomplicationspregnancy |
| spellingShingle | Friederike Weschenfelder Janine Zöllkau Anna Schohe Ulrich Pecks Tanja Groten Ute Schaefer-Graf on behalf of CRONOS-Network Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network) Journal of Clinical Medicine obesity overweight SARS-CoV-2 COVID complications pregnancy |
| title | Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network) |
| title_full | Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network) |
| title_fullStr | Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network) |
| title_full_unstemmed | Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network) |
| title_short | Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network) |
| title_sort | obesity during pregnancy and sars cov 2 covid 19 case series of the registry study covid 19 related obstetric and neonatal outcome study cronos network |
| topic | obesity overweight SARS-CoV-2 COVID complications pregnancy |
| url | https://www.mdpi.com/2077-0383/12/6/2089 |
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