Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility
Purpose: The aim of this study was to investigate the effect of human chorionic gonadotropin (hCG) in hormone replacement (HT) regime for frozen thawed embryo transfer in women with endometriosis (EM).Methods: We performed a retrospective, database-search, cohort study and included data on EM patien...
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Frontiers Media S.A.
2020-12-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2020.592921/full |
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| author | Yanbo Du Lei Yan Lei Yan Lei Yan Mei Sun Mei Sun Yan Sheng Yan Sheng Xiufang Li Zhenhua Feng Rong Tang Rong Tang |
| author_facet | Yanbo Du Lei Yan Lei Yan Lei Yan Mei Sun Mei Sun Yan Sheng Yan Sheng Xiufang Li Zhenhua Feng Rong Tang Rong Tang |
| author_sort | Yanbo Du |
| collection | DOAJ |
| description | Purpose: The aim of this study was to investigate the effect of human chorionic gonadotropin (hCG) in hormone replacement (HT) regime for frozen thawed embryo transfer in women with endometriosis (EM).Methods: We performed a retrospective, database-search, cohort study and included data on EM patients who underwent frozen embryo transfer (FET) between January 1, 2009 and August 31, 2018. According to the protocols for FET cycle, the patients were divided into two groups: control group (n = 296) and hCG group (n = 355). Clinical pregnancy rate, live birth rate, early abortion rate, late abortion rate, and ectopic pregnancy rate were compared between the two groups.Results: There was a significant increase in clinical pregnancy rate in the hCG group (57.7 vs. 49%, p = 0.027) compared with the control group. The live birth rate in the hCG group (45.6 vs. 38.5%, p = 0.080) was also elevated, but this difference was not statistically significant.Conclusion: hCG administration in HT regime for FET increases the pregnancy rate in women with EM. |
| first_indexed | 2024-12-13T13:26:15Z |
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| id | doaj.art-2d4205a8e61b4f3eb31f8b0f4dac29e4 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-13T13:26:15Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-2d4205a8e61b4f3eb31f8b0f4dac29e42022-12-21T23:44:18ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2020-12-01710.3389/fmed.2020.592921592921Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated InfertilityYanbo Du0Lei Yan1Lei Yan2Lei Yan3Mei Sun4Mei Sun5Yan Sheng6Yan Sheng7Xiufang Li8Zhenhua Feng9Rong Tang10Rong Tang11Reproductive Hospital Affiliated to Shandong University, Jinan, ChinaReproductive Hospital Affiliated to Shandong University, Jinan, ChinaSchool of Medicine, Shandong University, Jinan, ChinaNational Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology, Shandong University, Ministry of Education, Jinan, ChinaReproductive Hospital Affiliated to Shandong University, Jinan, ChinaShandong Provincial Hospital, Jinan, ChinaReproductive Hospital Affiliated to Shandong University, Jinan, ChinaShandong Provincial Hospital, Jinan, ChinaReproductive Hospital Affiliated to Shandong University, Jinan, ChinaReproductive Hospital Affiliated to Shandong University, Jinan, ChinaReproductive Hospital Affiliated to Shandong University, Jinan, ChinaShandong Provincial Hospital, Jinan, ChinaPurpose: The aim of this study was to investigate the effect of human chorionic gonadotropin (hCG) in hormone replacement (HT) regime for frozen thawed embryo transfer in women with endometriosis (EM).Methods: We performed a retrospective, database-search, cohort study and included data on EM patients who underwent frozen embryo transfer (FET) between January 1, 2009 and August 31, 2018. According to the protocols for FET cycle, the patients were divided into two groups: control group (n = 296) and hCG group (n = 355). Clinical pregnancy rate, live birth rate, early abortion rate, late abortion rate, and ectopic pregnancy rate were compared between the two groups.Results: There was a significant increase in clinical pregnancy rate in the hCG group (57.7 vs. 49%, p = 0.027) compared with the control group. The live birth rate in the hCG group (45.6 vs. 38.5%, p = 0.080) was also elevated, but this difference was not statistically significant.Conclusion: hCG administration in HT regime for FET increases the pregnancy rate in women with EM.https://www.frontiersin.org/articles/10.3389/fmed.2020.592921/fullendometriosisfrozen embryo transferhuman chorionic gonadotropinhormone replacementassisted reproductive technology |
| spellingShingle | Yanbo Du Lei Yan Lei Yan Lei Yan Mei Sun Mei Sun Yan Sheng Yan Sheng Xiufang Li Zhenhua Feng Rong Tang Rong Tang Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility Frontiers in Medicine endometriosis frozen embryo transfer human chorionic gonadotropin hormone replacement assisted reproductive technology |
| title | Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility |
| title_full | Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility |
| title_fullStr | Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility |
| title_full_unstemmed | Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility |
| title_short | Effect of Human Chorionic Gonadotropin Injection Before Frozen Embryo Transfer on Pregnancy Outcomes in Endometriosis-Associated Infertility |
| title_sort | effect of human chorionic gonadotropin injection before frozen embryo transfer on pregnancy outcomes in endometriosis associated infertility |
| topic | endometriosis frozen embryo transfer human chorionic gonadotropin hormone replacement assisted reproductive technology |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2020.592921/full |
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