Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach
Pleural aspergillosis (PA) is a rare but potentially fatal disease. Most cases are secondary to bronchopleural fistulae or pleural intervention and can occur in the absence of immunosuppression.We report a case of PA in a young patient after pleurodesis for recurrent pneumothorax. Clinical resolutio...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Medical Mycology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211753920300130 |
| _version_ | 1811205938959351808 |
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| author | Isabel Abreu Mariana Guedes Raquel Duro Sara Lopes João Maciel Lurdes Santos |
| author_facet | Isabel Abreu Mariana Guedes Raquel Duro Sara Lopes João Maciel Lurdes Santos |
| author_sort | Isabel Abreu |
| collection | DOAJ |
| description | Pleural aspergillosis (PA) is a rare but potentially fatal disease. Most cases are secondary to bronchopleural fistulae or pleural intervention and can occur in the absence of immunosuppression.We report a case of PA in a young patient after pleurodesis for recurrent pneumothorax. Clinical resolution was achieved with systemic and local antifungal therapy combined with surgical debridement. Hepatotoxicity led to a switch from voriconazole to isavuconazole, with a successful outcome. |
| first_indexed | 2024-04-12T03:39:37Z |
| format | Article |
| id | doaj.art-2d44fe1ffad245afab4f182a3702076c |
| institution | Directory Open Access Journal |
| issn | 2211-7539 |
| language | English |
| last_indexed | 2024-04-12T03:39:37Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medical Mycology Case Reports |
| spelling | doaj.art-2d44fe1ffad245afab4f182a3702076c2022-12-22T03:49:19ZengElsevierMedical Mycology Case Reports2211-75392020-06-012847Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approachIsabel Abreu0Mariana Guedes1Raquel Duro2Sara Lopes3João Maciel4Lurdes Santos5Infectious Diseases Department, Centro Hospitalar Universitário de São João, Alameda Prof. Hernâni Monteiro, Oporto, 4200-319, Portugal; Corresponding author.Infectious Diseases Department, Centro Hospitalar Universitário de São João, Alameda Prof. Hernâni Monteiro, Oporto, 4200-319, PortugalInfectious Diseases Department, Centro Hospitalar Universitário de São João, Alameda Prof. Hernâni Monteiro, Oporto, 4200-319, PortugalCardiothoracic Surgery Department, Centro Hospitalar Universitário de São João, Alameda Prof. Hernâni Monteiro, Oporto, 4200-319, PortugalCardiothoracic Surgery Department, Centro Hospitalar Universitário de São João, Alameda Prof. Hernâni Monteiro, Oporto, 4200-319, PortugalInfectious Diseases Department, Centro Hospitalar Universitário de São João, Alameda Prof. Hernâni Monteiro, Oporto, 4200-319, PortugalPleural aspergillosis (PA) is a rare but potentially fatal disease. Most cases are secondary to bronchopleural fistulae or pleural intervention and can occur in the absence of immunosuppression.We report a case of PA in a young patient after pleurodesis for recurrent pneumothorax. Clinical resolution was achieved with systemic and local antifungal therapy combined with surgical debridement. Hepatotoxicity led to a switch from voriconazole to isavuconazole, with a successful outcome.http://www.sciencedirect.com/science/article/pii/S2211753920300130Recurrent pneumothoraxPleural aspergillosisPleural instillationHepatotoxicityIsavuconazole |
| spellingShingle | Isabel Abreu Mariana Guedes Raquel Duro Sara Lopes João Maciel Lurdes Santos Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach Medical Mycology Case Reports Recurrent pneumothorax Pleural aspergillosis Pleural instillation Hepatotoxicity Isavuconazole |
| title | Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach |
| title_full | Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach |
| title_fullStr | Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach |
| title_full_unstemmed | Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach |
| title_short | Pleural aspergillosis in a patient with recurrent spontaneous pneumothorax: The challenge of an optimal therapeutic approach |
| title_sort | pleural aspergillosis in a patient with recurrent spontaneous pneumothorax the challenge of an optimal therapeutic approach |
| topic | Recurrent pneumothorax Pleural aspergillosis Pleural instillation Hepatotoxicity Isavuconazole |
| url | http://www.sciencedirect.com/science/article/pii/S2211753920300130 |
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