COMPARATIVE EFFICIENCY AND TOLERABILITY OF CURRENT THERAPIES FOR EARLY RHEUMATOID ARTHRITIS
Objective: to compare the efficiency and safety of four treatment regimens using methotrexate (MT), leflunomide (LEF), and a combination of MT and glucocorticoids (GC) for early rheumatoid arthritis (RA) (disease duration <2 years).Subjects and methods. 141 patients with early RA (of th...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2015-04-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2071 |
| _version_ | 1797862704704126976 |
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| author | E. V. Fedorenko G. V. Lukina Ya. A. Sigidin E. L. Luchikhina D. E. Karateev |
| author_facet | E. V. Fedorenko G. V. Lukina Ya. A. Sigidin E. L. Luchikhina D. E. Karateev |
| author_sort | E. V. Fedorenko |
| collection | DOAJ |
| description | Objective: to compare the efficiency and safety of four treatment regimens using methotrexate (MT), leflunomide (LEF), and a combination of MT and glucocorticoids (GC) for early rheumatoid arthritis (RA) (disease duration <2 years).Subjects and methods. 141 patients with early RA (of them there were 122 women; mean age 51 years; mean disease duration 7.8 months; mean DAS28 6.0) were randomized to 4 treatment groups: 1) MT 10–20 mg/week (n = 35); 2) MT 10–20 mg/week + oral GC equivalent to 10 mg/day of prednisolone (n = 34); 3) MT 10–20 mg/week + oral CG + single intravenous administration of methylprednisolone (MP) 1000 mg at baseline (n = 35); 4) LEF 20 mg/day (n = 37). The patients were matched for main clinical and demographic characteristics. The duration of treatment was 1 year. Its efficiency was evaluated according to the European League Against Rheumatism (EULAR) criteria.Results. 125 patients completed one-year treatment. At this time, 11.4% of the patients achieved remission (DAS28 <2.6) in the MT group, 37.5% in the MT+GC group, 29.4% in the MT+GC+MP group, and 16.2% in the LEF group. Adverse events, mainly of mild intensity, were recorded in 9 patients in each MT group. A total of 7 patients had to discontinue treatment because of its inefficiency.Conclusion. All the four therapy regimens demonstrated a significant efficiency in patients with early RA; the total remission rate was 24%. The combination of MT and GC produced the most pronounced effect. The tolerability of treatment was good in all groups. |
| first_indexed | 2024-04-09T22:24:52Z |
| format | Article |
| id | doaj.art-2d451295571a47b0998e310b7e9fed86 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:24:52Z |
| publishDate | 2015-04-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-2d451295571a47b0998e310b7e9fed862023-03-22T13:45:50ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922015-04-0153216216810.14412/1995-4484-2015-162-1681961COMPARATIVE EFFICIENCY AND TOLERABILITY OF CURRENT THERAPIES FOR EARLY RHEUMATOID ARTHRITISE. V. Fedorenko0G. V. Lukina1Ya. A. Sigidin2E. L. Luchikhina3D. E. Karateev4Научноисследовательский институт ревматологии им. В.А. Насоновой, МоскваV.A. Nasonova Research Institute of Rheumatology, MoscowV.A. Nasonova Research Institute of Rheumatology, MoscowV.A. Nasonova Research Institute of Rheumatology, MoscowV.A. Nasonova Research Institute of Rheumatology, MoscowObjective: to compare the efficiency and safety of four treatment regimens using methotrexate (MT), leflunomide (LEF), and a combination of MT and glucocorticoids (GC) for early rheumatoid arthritis (RA) (disease duration <2 years).Subjects and methods. 141 patients with early RA (of them there were 122 women; mean age 51 years; mean disease duration 7.8 months; mean DAS28 6.0) were randomized to 4 treatment groups: 1) MT 10–20 mg/week (n = 35); 2) MT 10–20 mg/week + oral GC equivalent to 10 mg/day of prednisolone (n = 34); 3) MT 10–20 mg/week + oral CG + single intravenous administration of methylprednisolone (MP) 1000 mg at baseline (n = 35); 4) LEF 20 mg/day (n = 37). The patients were matched for main clinical and demographic characteristics. The duration of treatment was 1 year. Its efficiency was evaluated according to the European League Against Rheumatism (EULAR) criteria.Results. 125 patients completed one-year treatment. At this time, 11.4% of the patients achieved remission (DAS28 <2.6) in the MT group, 37.5% in the MT+GC group, 29.4% in the MT+GC+MP group, and 16.2% in the LEF group. Adverse events, mainly of mild intensity, were recorded in 9 patients in each MT group. A total of 7 patients had to discontinue treatment because of its inefficiency.Conclusion. All the four therapy regimens demonstrated a significant efficiency in patients with early RA; the total remission rate was 24%. The combination of MT and GC produced the most pronounced effect. The tolerability of treatment was good in all groups.https://rsp.mediar-press.net/rsp/article/view/2071rheumatoid arthritisefficiencymethotrexateleflunomideglucocorticoids |
| spellingShingle | E. V. Fedorenko G. V. Lukina Ya. A. Sigidin E. L. Luchikhina D. E. Karateev COMPARATIVE EFFICIENCY AND TOLERABILITY OF CURRENT THERAPIES FOR EARLY RHEUMATOID ARTHRITIS Научно-практическая ревматология rheumatoid arthritis efficiency methotrexate leflunomide glucocorticoids |
| title | COMPARATIVE EFFICIENCY AND TOLERABILITY OF CURRENT THERAPIES FOR EARLY RHEUMATOID ARTHRITIS |
| title_full | COMPARATIVE EFFICIENCY AND TOLERABILITY OF CURRENT THERAPIES FOR EARLY RHEUMATOID ARTHRITIS |
| title_fullStr | COMPARATIVE EFFICIENCY AND TOLERABILITY OF CURRENT THERAPIES FOR EARLY RHEUMATOID ARTHRITIS |
| title_full_unstemmed | COMPARATIVE EFFICIENCY AND TOLERABILITY OF CURRENT THERAPIES FOR EARLY RHEUMATOID ARTHRITIS |
| title_short | COMPARATIVE EFFICIENCY AND TOLERABILITY OF CURRENT THERAPIES FOR EARLY RHEUMATOID ARTHRITIS |
| title_sort | comparative efficiency and tolerability of current therapies for early rheumatoid arthritis |
| topic | rheumatoid arthritis efficiency methotrexate leflunomide glucocorticoids |
| url | https://rsp.mediar-press.net/rsp/article/view/2071 |
| work_keys_str_mv | AT evfedorenko comparativeefficiencyandtolerabilityofcurrenttherapiesforearlyrheumatoidarthritis AT gvlukina comparativeefficiencyandtolerabilityofcurrenttherapiesforearlyrheumatoidarthritis AT yaasigidin comparativeefficiencyandtolerabilityofcurrenttherapiesforearlyrheumatoidarthritis AT elluchikhina comparativeefficiencyandtolerabilityofcurrenttherapiesforearlyrheumatoidarthritis AT dekarateev comparativeefficiencyandtolerabilityofcurrenttherapiesforearlyrheumatoidarthritis |