Understanding myocardial infarction [version 1; referees: 2 approved]
Over the last 40 years, our understanding of the pathogenesis of myocardial infarction has evolved and allowed new treatment strategies that have greatly improved survival. Over the years, there has been a radical shift in therapy from passive healing of the infarction through weeks of bed rest to e...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2018-09-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/7-1378/v1 |
| _version_ | 1828395959575379968 |
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| author | Moussa Saleh John A Ambrose |
| author_facet | Moussa Saleh John A Ambrose |
| author_sort | Moussa Saleh |
| collection | DOAJ |
| description | Over the last 40 years, our understanding of the pathogenesis of myocardial infarction has evolved and allowed new treatment strategies that have greatly improved survival. Over the years, there has been a radical shift in therapy from passive healing of the infarction through weeks of bed rest to early discharge usually within 2 to 3 days as a result of immediate reperfusion strategies and other guideline-directed medical therapies. Nevertheless, challenges remain. Patients who develop cardiogenic shock still face a high 30-day mortality of at least 40%. Perhaps even more important is how do we identify and prevent patients from developing myocardial infarction in the first place? This article discusses these milestones of therapy and considers important issues for progress in the future. |
| first_indexed | 2024-12-10T08:20:52Z |
| format | Article |
| id | doaj.art-2d471f4e8a7c4226ae9cd4e893f5f6b0 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-10T08:20:52Z |
| publishDate | 2018-09-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-2d471f4e8a7c4226ae9cd4e893f5f6b02022-12-22T01:56:20ZengF1000 Research LtdF1000Research2046-14022018-09-01710.12688/f1000research.15096.116443Understanding myocardial infarction [version 1; referees: 2 approved]Moussa Saleh0John A Ambrose1Division of Cardiology, Department of Internal Medicine, University of California San Francisco-Fresno, 2335 E. Kashian Lane, Suite 460, Fresno, CA 97301, USADivision of Cardiology, Department of Internal Medicine, University of California San Francisco-Fresno, 2335 E. Kashian Lane, Suite 460, Fresno, CA 97301, USAOver the last 40 years, our understanding of the pathogenesis of myocardial infarction has evolved and allowed new treatment strategies that have greatly improved survival. Over the years, there has been a radical shift in therapy from passive healing of the infarction through weeks of bed rest to early discharge usually within 2 to 3 days as a result of immediate reperfusion strategies and other guideline-directed medical therapies. Nevertheless, challenges remain. Patients who develop cardiogenic shock still face a high 30-day mortality of at least 40%. Perhaps even more important is how do we identify and prevent patients from developing myocardial infarction in the first place? This article discusses these milestones of therapy and considers important issues for progress in the future.https://f1000research.com/articles/7-1378/v1 |
| spellingShingle | Moussa Saleh John A Ambrose Understanding myocardial infarction [version 1; referees: 2 approved] F1000Research |
| title | Understanding myocardial infarction [version 1; referees: 2 approved] |
| title_full | Understanding myocardial infarction [version 1; referees: 2 approved] |
| title_fullStr | Understanding myocardial infarction [version 1; referees: 2 approved] |
| title_full_unstemmed | Understanding myocardial infarction [version 1; referees: 2 approved] |
| title_short | Understanding myocardial infarction [version 1; referees: 2 approved] |
| title_sort | understanding myocardial infarction version 1 referees 2 approved |
| url | https://f1000research.com/articles/7-1378/v1 |
| work_keys_str_mv | AT moussasaleh understandingmyocardialinfarctionversion1referees2approved AT johnaambrose understandingmyocardialinfarctionversion1referees2approved |