Nanometer size silicon particles for hyperpolarized MRI
Abstract Hyperpolarized silicon particles have been shown to exhibit long spin-lattice relaxation times at room temperature, making them interesting as novel MRI probes. Demonstrations of hyperpolarized silicon particle imaging have focused on large micron size particles (average particle size (APS)...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-08709-0 |
| _version_ | 1818420387951673344 |
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| author | Grzegorz Kwiatkowski Fabian Jähnig Jonas Steinhauser Patrick Wespi Matthias Ernst Sebastian Kozerke |
| author_facet | Grzegorz Kwiatkowski Fabian Jähnig Jonas Steinhauser Patrick Wespi Matthias Ernst Sebastian Kozerke |
| author_sort | Grzegorz Kwiatkowski |
| collection | DOAJ |
| description | Abstract Hyperpolarized silicon particles have been shown to exhibit long spin-lattice relaxation times at room temperature, making them interesting as novel MRI probes. Demonstrations of hyperpolarized silicon particle imaging have focused on large micron size particles (average particle size (APS) = 2.2 μm) as they have, to date, demonstrated much larger polarizations than nanoparticles. We show that also much smaller silicon-29 particles (APS = 55 ± 12 nm) can be hyperpolarized with superior properties. A maximum polarization of 12.6% in the solid state is reported with a spin-lattice relaxation time of 42 min at room temperature thereby opening a new window for MRI applications. |
| first_indexed | 2024-12-14T12:53:40Z |
| format | Article |
| id | doaj.art-2d48c3118cfa4af8bc9fe9b9daedd22c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T12:53:40Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2d48c3118cfa4af8bc9fe9b9daedd22c2022-12-21T23:00:37ZengNature PortfolioScientific Reports2045-23222017-08-01711610.1038/s41598-017-08709-0Nanometer size silicon particles for hyperpolarized MRIGrzegorz Kwiatkowski0Fabian Jähnig1Jonas Steinhauser2Patrick Wespi3Matthias Ernst4Sebastian Kozerke5Institute for Biomedical Engineering, University and ETH ZurichLaboratory of Physical Chemistry, ETH ZurichInstitute for Biomedical Engineering, University and ETH ZurichInstitute for Biomedical Engineering, University and ETH ZurichLaboratory of Physical Chemistry, ETH ZurichInstitute for Biomedical Engineering, University and ETH ZurichAbstract Hyperpolarized silicon particles have been shown to exhibit long spin-lattice relaxation times at room temperature, making them interesting as novel MRI probes. Demonstrations of hyperpolarized silicon particle imaging have focused on large micron size particles (average particle size (APS) = 2.2 μm) as they have, to date, demonstrated much larger polarizations than nanoparticles. We show that also much smaller silicon-29 particles (APS = 55 ± 12 nm) can be hyperpolarized with superior properties. A maximum polarization of 12.6% in the solid state is reported with a spin-lattice relaxation time of 42 min at room temperature thereby opening a new window for MRI applications.https://doi.org/10.1038/s41598-017-08709-0 |
| spellingShingle | Grzegorz Kwiatkowski Fabian Jähnig Jonas Steinhauser Patrick Wespi Matthias Ernst Sebastian Kozerke Nanometer size silicon particles for hyperpolarized MRI Scientific Reports |
| title | Nanometer size silicon particles for hyperpolarized MRI |
| title_full | Nanometer size silicon particles for hyperpolarized MRI |
| title_fullStr | Nanometer size silicon particles for hyperpolarized MRI |
| title_full_unstemmed | Nanometer size silicon particles for hyperpolarized MRI |
| title_short | Nanometer size silicon particles for hyperpolarized MRI |
| title_sort | nanometer size silicon particles for hyperpolarized mri |
| url | https://doi.org/10.1038/s41598-017-08709-0 |
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