The Association between Kidney Function Biomarkers and Delayed Memory Impairments among Older Adults in the European North of Russia
The prevention of memory decline requires better knowledge of biological markers. We studied the associations between kidney function biomarkers and memory decline (assessed with the Mini-Mental State Examination—MMSE) in elderly individuals without dementia (MMSE 24–30, age 60–74 years, <i>n&...
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MDPI AG
2023-11-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/12/1664 |
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| author | Liliya Poskotinova Anna Kontsevaya Alexander V. Kudryavtsev |
| author_facet | Liliya Poskotinova Anna Kontsevaya Alexander V. Kudryavtsev |
| author_sort | Liliya Poskotinova |
| collection | DOAJ |
| description | The prevention of memory decline requires better knowledge of biological markers. We studied the associations between kidney function biomarkers and memory decline (assessed with the Mini-Mental State Examination—MMSE) in elderly individuals without dementia (MMSE 24–30, age 60–74 years, <i>n</i> = 643, Arkhangelsk, Russia). Participants were divided by sex and into three groups according to the delayed memory performance: recall of 0–1, 2, and 3 out of 3 words. The median of serum creatinine was 82 μmol/L in men who recalled 2 words and both medians in those recalling 3 and 0–1 words were 87 μmol/L. The 90th percentile for creatinine in men recalling 0–1 words (115.0 μmol/L) exceeded the upper limit of the normal range (110.5 μmol/L), while those who recalled 3 and 2 words had 90th percentiles within the normal range (109 and 101 μmol/L, respectively). Glomerular filtration rates were normal (≥60 mL/min/1.73 m<sup>2</sup>) with a median of 92.0 mL/min/1.73 m<sup>2</sup> in men who recalled 2 words, 84.4 and 84.9 mL/min/1.73 m<sup>2</sup> in men who recalled 3 and 0–1 words, respectively. None of these associations were observed in women. A reduced serum creatinine in older non-demented men may indicate the initial stages of memory decline, while the increased creatinine may reflect further stages of memory impairment. |
| first_indexed | 2024-03-08T20:56:32Z |
| format | Article |
| id | doaj.art-2d498e1e661c471786613d2efd4b1011 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-08T20:56:32Z |
| publishDate | 2023-11-01 |
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| series | Brain Sciences |
| spelling | doaj.art-2d498e1e661c471786613d2efd4b10112023-12-22T13:57:09ZengMDPI AGBrain Sciences2076-34252023-11-011312166410.3390/brainsci13121664The Association between Kidney Function Biomarkers and Delayed Memory Impairments among Older Adults in the European North of RussiaLiliya Poskotinova0Anna Kontsevaya1Alexander V. Kudryavtsev2Biorhythmology Laboratory of the Institute of Environmental Physiology, N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, 163001 Arkhangelsk, RussiaDepartment of Public Health, National Medical Research Centre for Therapy and Preventive Medicine, 101000 Moscow, RussiaCentral Scientific Research Laboratory, Northern State Medical University, 163069 Arkhangelsk, RussiaThe prevention of memory decline requires better knowledge of biological markers. We studied the associations between kidney function biomarkers and memory decline (assessed with the Mini-Mental State Examination—MMSE) in elderly individuals without dementia (MMSE 24–30, age 60–74 years, <i>n</i> = 643, Arkhangelsk, Russia). Participants were divided by sex and into three groups according to the delayed memory performance: recall of 0–1, 2, and 3 out of 3 words. The median of serum creatinine was 82 μmol/L in men who recalled 2 words and both medians in those recalling 3 and 0–1 words were 87 μmol/L. The 90th percentile for creatinine in men recalling 0–1 words (115.0 μmol/L) exceeded the upper limit of the normal range (110.5 μmol/L), while those who recalled 3 and 2 words had 90th percentiles within the normal range (109 and 101 μmol/L, respectively). Glomerular filtration rates were normal (≥60 mL/min/1.73 m<sup>2</sup>) with a median of 92.0 mL/min/1.73 m<sup>2</sup> in men who recalled 2 words, 84.4 and 84.9 mL/min/1.73 m<sup>2</sup> in men who recalled 3 and 0–1 words, respectively. None of these associations were observed in women. A reduced serum creatinine in older non-demented men may indicate the initial stages of memory decline, while the increased creatinine may reflect further stages of memory impairment.https://www.mdpi.com/2076-3425/13/12/1664agingdelayed memorykidney functionintrinsic capacity |
| spellingShingle | Liliya Poskotinova Anna Kontsevaya Alexander V. Kudryavtsev The Association between Kidney Function Biomarkers and Delayed Memory Impairments among Older Adults in the European North of Russia Brain Sciences aging delayed memory kidney function intrinsic capacity |
| title | The Association between Kidney Function Biomarkers and Delayed Memory Impairments among Older Adults in the European North of Russia |
| title_full | The Association between Kidney Function Biomarkers and Delayed Memory Impairments among Older Adults in the European North of Russia |
| title_fullStr | The Association between Kidney Function Biomarkers and Delayed Memory Impairments among Older Adults in the European North of Russia |
| title_full_unstemmed | The Association between Kidney Function Biomarkers and Delayed Memory Impairments among Older Adults in the European North of Russia |
| title_short | The Association between Kidney Function Biomarkers and Delayed Memory Impairments among Older Adults in the European North of Russia |
| title_sort | association between kidney function biomarkers and delayed memory impairments among older adults in the european north of russia |
| topic | aging delayed memory kidney function intrinsic capacity |
| url | https://www.mdpi.com/2076-3425/13/12/1664 |
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