Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective
Cancer is a life-threatening disease, and there is a significant need for novel technologies to treat cancer with an effective outcome and low toxicity. Photothermal therapy (PTT) is a noninvasive therapeutic tool that transports nanomaterials into tumors, absorbing light energy and converting it in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.664123/full |
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| author | Shengnan Liao Wang Yue Shuning Cai Quan Tang Weitong Lu Lingxiao Huang Tingting Qi Tingting Qi Jinfeng Liao |
| author_facet | Shengnan Liao Wang Yue Shuning Cai Quan Tang Weitong Lu Lingxiao Huang Tingting Qi Tingting Qi Jinfeng Liao |
| author_sort | Shengnan Liao |
| collection | DOAJ |
| description | Cancer is a life-threatening disease, and there is a significant need for novel technologies to treat cancer with an effective outcome and low toxicity. Photothermal therapy (PTT) is a noninvasive therapeutic tool that transports nanomaterials into tumors, absorbing light energy and converting it into heat, thus killing tumor cells. Gold nanorods (GNRs) have attracted widespread attention in recent years due to their unique optical and electronic properties and potential applications in biological imaging, molecular detection, and drug delivery, especially in the PTT of cancer and other diseases. This review summarizes the recent progress in the synthesis methods and surface functionalization of GNRs for PTT. The current major synthetic methods of GNRs and recently improved measures to reduce toxicity, increase yield, and control particle size and shape are first introduced, followed by various surface functionalization approaches to construct a controlled drug release system, increase cell uptake, and improve pharmacokinetics and tumor-targeting effect, thus enhancing the photothermal effect of killing the tumor. Finally, a brief outlook for the future development of GNRs modification and functionalization in PTT is proposed. |
| first_indexed | 2024-12-14T21:04:11Z |
| format | Article |
| id | doaj.art-2d49f95480cd4606bf73cdeeaacda8ec |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-14T21:04:11Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2d49f95480cd4606bf73cdeeaacda8ec2022-12-21T22:47:30ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-04-011210.3389/fphar.2021.664123664123Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and PerspectiveShengnan Liao0Wang Yue1Shuning Cai2Quan Tang3Weitong Lu4Lingxiao Huang5Tingting Qi6Tingting Qi7Jinfeng Liao8State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaDepartment of Radiation Biology, Radiation Oncology Key Laboratory of Sichuan Province, Department of Clinical Pharmacy, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Radiation Biology, Radiation Oncology Key Laboratory of Sichuan Province, Department of Clinical Pharmacy, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaCancer is a life-threatening disease, and there is a significant need for novel technologies to treat cancer with an effective outcome and low toxicity. Photothermal therapy (PTT) is a noninvasive therapeutic tool that transports nanomaterials into tumors, absorbing light energy and converting it into heat, thus killing tumor cells. Gold nanorods (GNRs) have attracted widespread attention in recent years due to their unique optical and electronic properties and potential applications in biological imaging, molecular detection, and drug delivery, especially in the PTT of cancer and other diseases. This review summarizes the recent progress in the synthesis methods and surface functionalization of GNRs for PTT. The current major synthetic methods of GNRs and recently improved measures to reduce toxicity, increase yield, and control particle size and shape are first introduced, followed by various surface functionalization approaches to construct a controlled drug release system, increase cell uptake, and improve pharmacokinetics and tumor-targeting effect, thus enhancing the photothermal effect of killing the tumor. Finally, a brief outlook for the future development of GNRs modification and functionalization in PTT is proposed.https://www.frontiersin.org/articles/10.3389/fphar.2021.664123/fullCancerPhotothermal therapyLocalized tumor treatmentGold nanorodsNanomaterials |
| spellingShingle | Shengnan Liao Wang Yue Shuning Cai Quan Tang Weitong Lu Lingxiao Huang Tingting Qi Tingting Qi Jinfeng Liao Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective Frontiers in Pharmacology Cancer Photothermal therapy Localized tumor treatment Gold nanorods Nanomaterials |
| title | Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective |
| title_full | Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective |
| title_fullStr | Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective |
| title_full_unstemmed | Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective |
| title_short | Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective |
| title_sort | improvement of gold nanorods in photothermal therapy recent progress and perspective |
| topic | Cancer Photothermal therapy Localized tumor treatment Gold nanorods Nanomaterials |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.664123/full |
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