A New Strategy for Nucleic Acid Delivery and Protein Expression Using Biocompatible Nanohydrogels of Predefined Sizes

A New Strategy for Nucleic Acid Delivery and Protein Expression Using Biocompatible Nanohydrogels of Predefined Sizes

We have developed new formulations of nanohydrogels (NHGs) complexed with DNA devoid of cell toxicity, which, together with their tuned sizes, makes them of great interest for delivering DNA/RNA for foreign protein expression. Transfection results demonstrate that, unlike classical lipo/polyplexes,...

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Bibliographic Details
Main Authors: Lakshmanan Eswaran, Gila Kazimirsky, Ronen Yehuda, Gerardo Byk
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
self-assembly
polymerization
cationic nanohydrogels
non-viral gene delivery
Online Access:https://www.mdpi.com/1999-4923/15/3/961

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