The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest

The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest

The novel synthetic compound designated STK899704 (PubChem CID: 5455708) suppresses the proliferation of a broad range of cancer cell types. However, the details of its effect on lung cancer cells are unclear. We investigated the precise anticancer effect of STK899704 on senescence and growth arrest...

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Bibliographic Details
Main Authors: Chan-Woo Park, Yesol Bak, Min-Je Kim, Ganipisetti Srinivasrao, Joonsung Hwang, Nak K. Sung, Bo Yeon Kim, Jae-Hyuk Yu, Jin Tae Hong, Do-Young Yoon
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
lung carcinoma
STK899704
senescence
cancer therapy
cell cycle arrest
p53
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00163/full

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