Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs
The number of teats is a crucial reproductive trait with significant economic implications on maternal capacity and litter size. Consequently, improving this trait is essential to facilitate genetic selection for increased litter size. In this study, we performed a genome-wide association study (GWA...
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MDPI AG
2023-06-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/11/1880 |
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| author | Lijuan Yang Xuehua Li Zhanwei Zhuang Shenping Zhou Jie Wu Cineng Xu Donglin Ruan Yibin Qiu Hua Zhao Enqin Zheng Gengyuan Cai Zhenfang Wu Jie Yang |
| author_facet | Lijuan Yang Xuehua Li Zhanwei Zhuang Shenping Zhou Jie Wu Cineng Xu Donglin Ruan Yibin Qiu Hua Zhao Enqin Zheng Gengyuan Cai Zhenfang Wu Jie Yang |
| author_sort | Lijuan Yang |
| collection | DOAJ |
| description | The number of teats is a crucial reproductive trait with significant economic implications on maternal capacity and litter size. Consequently, improving this trait is essential to facilitate genetic selection for increased litter size. In this study, we performed a genome-wide association study (GWAS) of the number of teats in a three-way crossbred commercial Duroc × (Landrace × Yorkshire) (DLY) pig population comprising 1518 animals genotyped with the 50K BeadChip. Our analysis identified crucial quantitative trait loci (QTL) for the number of teats, containing the <i>ABCD4</i> and <i>VRTN</i> genes on porcine chromosome 7. Our results establish SNP variants of <i>ABCD4</i> and <i>VRTN</i> as new molecular markers for improving the number of teats in DLY pigs. Furthermore, the most significant noteworthy single nucleotide polymorphism (SNP) (7_97568284) was identified within the <i>ABCD4</i> gene, exhibiting a significant association with the total teat number traits. This SNP accounted for a substantial proportion of the genetic variance, explaining 6.64% of the observed variation. These findings reveal a novel gene on SSC7 for the number of teats and provide a deeper understanding of the genetic mechanisms underlying reproductive traits. |
| first_indexed | 2024-03-11T03:12:13Z |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T03:12:13Z |
| publishDate | 2023-06-01 |
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| series | Animals |
| spelling | doaj.art-2d4c659baa8349e18370c8fb13b781372023-11-18T07:30:56ZengMDPI AGAnimals2076-26152023-06-011311188010.3390/ani13111880Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial PigsLijuan Yang0Xuehua Li1Zhanwei Zhuang2Shenping Zhou3Jie Wu4Cineng Xu5Donglin Ruan6Yibin Qiu7Hua Zhao8Enqin Zheng9Gengyuan Cai10Zhenfang Wu11Jie Yang12College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaNational S&T Innovation Center for Modern Agricultural Industry, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaCollege of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, ChinaThe number of teats is a crucial reproductive trait with significant economic implications on maternal capacity and litter size. Consequently, improving this trait is essential to facilitate genetic selection for increased litter size. In this study, we performed a genome-wide association study (GWAS) of the number of teats in a three-way crossbred commercial Duroc × (Landrace × Yorkshire) (DLY) pig population comprising 1518 animals genotyped with the 50K BeadChip. Our analysis identified crucial quantitative trait loci (QTL) for the number of teats, containing the <i>ABCD4</i> and <i>VRTN</i> genes on porcine chromosome 7. Our results establish SNP variants of <i>ABCD4</i> and <i>VRTN</i> as new molecular markers for improving the number of teats in DLY pigs. Furthermore, the most significant noteworthy single nucleotide polymorphism (SNP) (7_97568284) was identified within the <i>ABCD4</i> gene, exhibiting a significant association with the total teat number traits. This SNP accounted for a substantial proportion of the genetic variance, explaining 6.64% of the observed variation. These findings reveal a novel gene on SSC7 for the number of teats and provide a deeper understanding of the genetic mechanisms underlying reproductive traits.https://www.mdpi.com/2076-2615/13/11/1880DLY pigsGWASSNPnumber of teats<i>ABCD4</i> |
| spellingShingle | Lijuan Yang Xuehua Li Zhanwei Zhuang Shenping Zhou Jie Wu Cineng Xu Donglin Ruan Yibin Qiu Hua Zhao Enqin Zheng Gengyuan Cai Zhenfang Wu Jie Yang Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs Animals DLY pigs GWAS SNP number of teats <i>ABCD4</i> |
| title | Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs |
| title_full | Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs |
| title_fullStr | Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs |
| title_full_unstemmed | Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs |
| title_short | Genome-Wide Association Study Identifies the Crucial Candidate Genes for Teat Number in Crossbred Commercial Pigs |
| title_sort | genome wide association study identifies the crucial candidate genes for teat number in crossbred commercial pigs |
| topic | DLY pigs GWAS SNP number of teats <i>ABCD4</i> |
| url | https://www.mdpi.com/2076-2615/13/11/1880 |
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