Sodium–glucose cotransporters: Functional properties and pharmaceutical potential
Abstract Glucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium–glucose cotransporters (SGLT...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-07-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13255 |
| _version_ | 1818595492868653056 |
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| author | Ryuhei Sano Yuichi Shinozaki Takeshi Ohta |
| author_facet | Ryuhei Sano Yuichi Shinozaki Takeshi Ohta |
| author_sort | Ryuhei Sano |
| collection | DOAJ |
| description | Abstract Glucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium–glucose cotransporters (SGLTs; gene name: solute carrier 5A). Each transporter has its own substrate specificity, distribution, and regulatory mechanisms. Recently, SGLT1 and SGLT2 have attracted much attention as therapeutic targets for various diseases. This review addresses the basal and functional properties of glucose transporters and SGLTs, and describes the pharmaceutical potential of SGLT1 and SGLT2. |
| first_indexed | 2024-12-16T11:16:53Z |
| format | Article |
| id | doaj.art-2d4cb81793024764b14e18e9f4187f80 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-16T11:16:53Z |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-2d4cb81793024764b14e18e9f4187f802022-12-21T22:33:34ZengWileyJournal of Diabetes Investigation2040-11162040-11242020-07-0111477078210.1111/jdi.13255Sodium–glucose cotransporters: Functional properties and pharmaceutical potentialRyuhei Sano0Yuichi Shinozaki1Takeshi Ohta2Biological/Pharmacological Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc Takatsuki JapanBiological/Pharmacological Research Laboratories Central Pharmaceutical Research Institute Japan Tobacco Inc Takatsuki JapanLaboratory of Animal Physiology and Functional Anatomy Graduate School of Agriculture Kyoto University Kyoto JapanAbstract Glucose is the most abundant monosaccharide, and an essential source of energy for most living cells. Glucose transport across the cell membrane is mediated by two types of transporters: facilitative glucose transporters (gene name: solute carrier 2A) and sodium–glucose cotransporters (SGLTs; gene name: solute carrier 5A). Each transporter has its own substrate specificity, distribution, and regulatory mechanisms. Recently, SGLT1 and SGLT2 have attracted much attention as therapeutic targets for various diseases. This review addresses the basal and functional properties of glucose transporters and SGLTs, and describes the pharmaceutical potential of SGLT1 and SGLT2.https://doi.org/10.1111/jdi.13255Antidiabetic drugsSodium–glucose cotransporter 1Sodium–glucose cotransporter 2 |
| spellingShingle | Ryuhei Sano Yuichi Shinozaki Takeshi Ohta Sodium–glucose cotransporters: Functional properties and pharmaceutical potential Journal of Diabetes Investigation Antidiabetic drugs Sodium–glucose cotransporter 1 Sodium–glucose cotransporter 2 |
| title | Sodium–glucose cotransporters: Functional properties and pharmaceutical potential |
| title_full | Sodium–glucose cotransporters: Functional properties and pharmaceutical potential |
| title_fullStr | Sodium–glucose cotransporters: Functional properties and pharmaceutical potential |
| title_full_unstemmed | Sodium–glucose cotransporters: Functional properties and pharmaceutical potential |
| title_short | Sodium–glucose cotransporters: Functional properties and pharmaceutical potential |
| title_sort | sodium glucose cotransporters functional properties and pharmaceutical potential |
| topic | Antidiabetic drugs Sodium–glucose cotransporter 1 Sodium–glucose cotransporter 2 |
| url | https://doi.org/10.1111/jdi.13255 |
| work_keys_str_mv | AT ryuheisano sodiumglucosecotransportersfunctionalpropertiesandpharmaceuticalpotential AT yuichishinozaki sodiumglucosecotransportersfunctionalpropertiesandpharmaceuticalpotential AT takeshiohta sodiumglucosecotransportersfunctionalpropertiesandpharmaceuticalpotential |