The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital
Aim: to define a role of hepatotropic (HAV, HBV, HCV, and HDV) and opportunistic hepatotropic (HGV, CMV, EBV, HHV types 1, 2, and 6) viruses in the etiological pattern of diseases accompanied by enhanced blood AlAT and AsAT activities in pregnant women. Subjects and methods. Two hundred and eleven p...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2010-11-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30736 |
| _version_ | 1818408841522446336 |
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| author | Kristina Rubenovna Dudina Ol'ga Olegovna Znoyko Yuliya Georgievna Trubitsyna Svetlana Anatol'evna Shut'ko Vladimir Nikolaevich Kuz'min Avet Grigor'evich Serobyan Naira Rubenovna Revazyan Natal'ya Petrovna Petrova Natal'ya Petrovna Blokhina Nikolay Dmitrievich Yushchuk K R Dudina O O Znoiko Yu G Trubitsyna S A Shutko V N Kuzmin A G Serobyan N R Revazyan T V Petrova N P Blokhina N D Yushchuk |
| author_facet | Kristina Rubenovna Dudina Ol'ga Olegovna Znoyko Yuliya Georgievna Trubitsyna Svetlana Anatol'evna Shut'ko Vladimir Nikolaevich Kuz'min Avet Grigor'evich Serobyan Naira Rubenovna Revazyan Natal'ya Petrovna Petrova Natal'ya Petrovna Blokhina Nikolay Dmitrievich Yushchuk K R Dudina O O Znoiko Yu G Trubitsyna S A Shutko V N Kuzmin A G Serobyan N R Revazyan T V Petrova N P Blokhina N D Yushchuk |
| author_sort | Kristina Rubenovna Dudina |
| collection | DOAJ |
| description | Aim: to define a role of hepatotropic (HAV, HBV, HCV, and HDV) and opportunistic hepatotropic (HGV, CMV, EBV, HHV types 1, 2, and 6) viruses in the etiological pattern of diseases accompanied by enhanced blood AlAT and AsAT activities in pregnant women.
Subjects and methods. Two hundred and eleven pregnant women, including 123 patients with chronic viral hepatitis, 74 with enhanced blood AlAT activity and no markers of viral hepatitis (EAlAT-NMVH), and 14 with acute viral hepatitis were examined.
Results. Most pregnant women with chronic HBV and HCV infections were found to have HBV DNA and HCV RNA in the blood in the presence of normal and enhanced activities of transaminases. In the EAlAT-NMVH group, there was none of the opportunistic hepatotropic viruses in more than 7% of cases. No genetic material of HAV, HBV, HCV, HDV, HGV, CMV, EBV, HHV types 1, 2, and 6 was found in the blood of all 10 patients with hepatitis of unspecified etiology.
Conclusion. In the absence of serologic data supporting the presence of infectious pathology, blood testing using the polymerase chain reaction is of low informative value in detecting opportunistic hepatotropic viruses in pregnant women with hepatitis of unspecified etiology. However, by keeping in mind that the spectrum of opportunistic hepatotropic viruses is not confined to those included in this study, it is expedient to examine additionally pregnant women with enhanced blood AlAT and AsAT activity in order to identify TTV, B19V, HHV-8, SEN and NV-F in the blood. |
| first_indexed | 2024-12-14T09:50:08Z |
| format | Article |
| id | doaj.art-2d4f6de85893457b83b02794a8ad4a8d |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-14T09:50:08Z |
| publishDate | 2010-11-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-2d4f6de85893457b83b02794a8ad4a8d2022-12-21T23:07:32Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422010-11-018211454827764The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospitalKristina Rubenovna DudinaOl'ga Olegovna ZnoykoYuliya Georgievna TrubitsynaSvetlana Anatol'evna Shut'koVladimir Nikolaevich Kuz'minAvet Grigor'evich SerobyanNaira Rubenovna RevazyanNatal'ya Petrovna PetrovaNatal'ya Petrovna BlokhinaNikolay Dmitrievich YushchukK R Dudina0O O Znoiko1Yu G Trubitsyna2S A Shutko3V N Kuzmin4A G Serobyan5N R Revazyan6T V Petrova7N P Blokhina8N D Yushchuk9Moscow State University of Medicine and DentistryMoscow State University of Medicine and DentistryMoscow State University of Medicine and DentistryMoscow State University of Medicine and DentistryMoscow State University of Medicine and DentistryInfectious Diseases Clinical Hospital One, Moscow Healthcare DepartmentInfectious Diseases Clinical Hospital One, Moscow Healthcare DepartmentZAO "NPF DNA-Technology"Infectious Diseases Clinical Hospital One, Moscow Healthcare DepartmentMoscow State University of Medicine and DentistryAim: to define a role of hepatotropic (HAV, HBV, HCV, and HDV) and opportunistic hepatotropic (HGV, CMV, EBV, HHV types 1, 2, and 6) viruses in the etiological pattern of diseases accompanied by enhanced blood AlAT and AsAT activities in pregnant women. Subjects and methods. Two hundred and eleven pregnant women, including 123 patients with chronic viral hepatitis, 74 with enhanced blood AlAT activity and no markers of viral hepatitis (EAlAT-NMVH), and 14 with acute viral hepatitis were examined. Results. Most pregnant women with chronic HBV and HCV infections were found to have HBV DNA and HCV RNA in the blood in the presence of normal and enhanced activities of transaminases. In the EAlAT-NMVH group, there was none of the opportunistic hepatotropic viruses in more than 7% of cases. No genetic material of HAV, HBV, HCV, HDV, HGV, CMV, EBV, HHV types 1, 2, and 6 was found in the blood of all 10 patients with hepatitis of unspecified etiology. Conclusion. In the absence of serologic data supporting the presence of infectious pathology, blood testing using the polymerase chain reaction is of low informative value in detecting opportunistic hepatotropic viruses in pregnant women with hepatitis of unspecified etiology. However, by keeping in mind that the spectrum of opportunistic hepatotropic viruses is not confined to those included in this study, it is expedient to examine additionally pregnant women with enhanced blood AlAT and AsAT activity in order to identify TTV, B19V, HHV-8, SEN and NV-F in the blood.https://ter-arkhiv.ru/0040-3660/article/view/30736pregnancyhepatotropic viruseschronic viral hepatitisalatasathepatitis of unspecified etiology |
| spellingShingle | Kristina Rubenovna Dudina Ol'ga Olegovna Znoyko Yuliya Georgievna Trubitsyna Svetlana Anatol'evna Shut'ko Vladimir Nikolaevich Kuz'min Avet Grigor'evich Serobyan Naira Rubenovna Revazyan Natal'ya Petrovna Petrova Natal'ya Petrovna Blokhina Nikolay Dmitrievich Yushchuk K R Dudina O O Znoiko Yu G Trubitsyna S A Shutko V N Kuzmin A G Serobyan N R Revazyan T V Petrova N P Blokhina N D Yushchuk The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital Терапевтический архив pregnancy hepatotropic viruses chronic viral hepatitis alat asat hepatitis of unspecified etiology |
| title | The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital |
| title_full | The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital |
| title_fullStr | The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital |
| title_full_unstemmed | The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital |
| title_short | The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital |
| title_sort | etiological pattern of diseases in pregnant women with enhanced blood alat and asat activities admitted to the obstetric unit of an infectious diseases hospital |
| topic | pregnancy hepatotropic viruses chronic viral hepatitis alat asat hepatitis of unspecified etiology |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30736 |
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