Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and meta-analysis
Abstract Prenatal vitamin D (PVD) is a vital micronutrient for dental caries (DCs). The association between prenatal vitamin D deficiencies (PVDD) and DCs in children has been conflicting in different reports. This meta-analysis aimed to investigate the association between PVDD and DCs in children f...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-024-06477-0 |
| _version_ | 1797208979268435968 |
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| author | Mansour Bahardoust Salar Salari Nader Ghotbi Elham Rahimpour Meisam Haghmoradi Homan Alipour Mahsa Soleimani |
| author_facet | Mansour Bahardoust Salar Salari Nader Ghotbi Elham Rahimpour Meisam Haghmoradi Homan Alipour Mahsa Soleimani |
| author_sort | Mansour Bahardoust |
| collection | DOAJ |
| description | Abstract Prenatal vitamin D (PVD) is a vital micronutrient for dental caries (DCs). The association between prenatal vitamin D deficiencies (PVDD) and DCs in children has been conflicting in different reports. This meta-analysis aimed to investigate the association between PVDD and DCs in children for the first time. We searched PubMed, Scopus, Web of Sciences, Embase, and Scholar databases to find relevant studies based on mesh terms from 2000 to October 2023. This study was conducted based on the 2020 version of the PRISMA checklist. Cochran’s Q and I2 tests were used to evaluate heterogeneity between studies. Egger’s test was used to evaluate publication bias. The effect size of the association between PVDD and DCs was reported by the odds ratio (OR) at the 95% confidence interval (95% CI).Twelve studies, including 11,021 participants, were reviewed. The pooled prevalence of PVDD was estimated at 4353 (32%). The prevalence of DCs in children of mothers with and without PVDD was 44% and 25%, respectively. PVDD was significantly associated with an increased risk of DCs in children (OR: 1.35, 95% CI (1.22, 1.47), I2 = 86.6%). The association of DCs with PVDD was different based on gestational age groups, children’s age groups, and vitamin D levels. This meta-analysis showed PVDD can be associated with an increased risk of DCs in children, especially in mothers with prenatal vitamin D levels ≤ 35 nmol/L. Adequate vitamin D levels throughout pregnancy can help prevent DCs in children. |
| first_indexed | 2024-04-24T09:47:24Z |
| format | Article |
| id | doaj.art-2d50827eef6b48bb8017ac854fe2312b |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-24T09:47:24Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-2d50827eef6b48bb8017ac854fe2312b2024-04-14T11:32:06ZengBMCBMC Pregnancy and Childbirth1471-23932024-04-0124111110.1186/s12884-024-06477-0Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and meta-analysisMansour Bahardoust0Salar Salari1Nader Ghotbi2Elham Rahimpour3Meisam Haghmoradi4Homan Alipour5Mahsa Soleimani6Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical SciencesGeneral Dentist, School of Dentistry, Isfahan Azad UniversityGeneral Dentist, School of Dentistry, Isfahan Azad UniversityShiraz University of Medical SciencesDepartment of Orthopedic Surgery, Urmia University of Medical SciencesTabriz University of Medical SciencesSchool of Medicine, Iran University of Medical SciencesAbstract Prenatal vitamin D (PVD) is a vital micronutrient for dental caries (DCs). The association between prenatal vitamin D deficiencies (PVDD) and DCs in children has been conflicting in different reports. This meta-analysis aimed to investigate the association between PVDD and DCs in children for the first time. We searched PubMed, Scopus, Web of Sciences, Embase, and Scholar databases to find relevant studies based on mesh terms from 2000 to October 2023. This study was conducted based on the 2020 version of the PRISMA checklist. Cochran’s Q and I2 tests were used to evaluate heterogeneity between studies. Egger’s test was used to evaluate publication bias. The effect size of the association between PVDD and DCs was reported by the odds ratio (OR) at the 95% confidence interval (95% CI).Twelve studies, including 11,021 participants, were reviewed. The pooled prevalence of PVDD was estimated at 4353 (32%). The prevalence of DCs in children of mothers with and without PVDD was 44% and 25%, respectively. PVDD was significantly associated with an increased risk of DCs in children (OR: 1.35, 95% CI (1.22, 1.47), I2 = 86.6%). The association of DCs with PVDD was different based on gestational age groups, children’s age groups, and vitamin D levels. This meta-analysis showed PVDD can be associated with an increased risk of DCs in children, especially in mothers with prenatal vitamin D levels ≤ 35 nmol/L. Adequate vitamin D levels throughout pregnancy can help prevent DCs in children.https://doi.org/10.1186/s12884-024-06477-0PrenatalVitamin D deficiencyDental cariesChildren |
| spellingShingle | Mansour Bahardoust Salar Salari Nader Ghotbi Elham Rahimpour Meisam Haghmoradi Homan Alipour Mahsa Soleimani Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and meta-analysis BMC Pregnancy and Childbirth Prenatal Vitamin D deficiency Dental caries Children |
| title | Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and meta-analysis |
| title_full | Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and meta-analysis |
| title_fullStr | Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and meta-analysis |
| title_full_unstemmed | Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and meta-analysis |
| title_short | Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and meta-analysis |
| title_sort | association between prenatal vitamin d deficiency with dental caries in infants and children a systematic review and meta analysis |
| topic | Prenatal Vitamin D deficiency Dental caries Children |
| url | https://doi.org/10.1186/s12884-024-06477-0 |
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