Application of functional connectivity neurofeedback in patients with treatment-resistant depression: A preliminary report
Functional connectivity neurofeedback (FCNef) is a technique that modulates synchronous neural activity through training and is being investigated as a potential novel treatment for patients suffering from treatment-resistant depression (TRD). An FCNef protocol, based on the analysis of resting-stat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of Affective Disorders Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666915323001828 |
| _version_ | 1797526168833884160 |
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| author | Masahiro Takamura Go Okada Toshiharu Kamishikiryo Eri Itai Miyuki Kato Tomokazu Motegi Jessica Elizabeth Taylor Toshinori Yoshioka Mitsuo Kawato Yasumasa Okamoto |
| author_facet | Masahiro Takamura Go Okada Toshiharu Kamishikiryo Eri Itai Miyuki Kato Tomokazu Motegi Jessica Elizabeth Taylor Toshinori Yoshioka Mitsuo Kawato Yasumasa Okamoto |
| author_sort | Masahiro Takamura |
| collection | DOAJ |
| description | Functional connectivity neurofeedback (FCNef) is a technique that modulates synchronous neural activity through training and is being investigated as a potential novel treatment for patients suffering from treatment-resistant depression (TRD). An FCNef protocol, based on the analysis of resting-state functional imaging data from a large cohort of depressed individuals, has been proposed to promote negative functional connectivity between the dorsolateral prefrontal cortex and the posterior cingulate cortex (DLPFC-PCC FC). This study aimed to assess the therapeutic efficacy and practicality of the protocol in a small sample of TRD patients. Of the six patients recruited, five completed the FCNef sessions. Depression and rumination scores significantly improved post-treatment, however, there were no significant changes in DLPFC-PCC FC. The study demonstrated efficacy of FCNef in ameliorating depressive symptoms, yet, it also indicated that the training itself may be burdensome for depressed patients, as evidenced by participants reporting fatigue (one of whom dropped out). Thus, a more efficient and less burdensome protocol is needed for future investigations and applications. |
| first_indexed | 2024-03-10T09:25:24Z |
| format | Article |
| id | doaj.art-2d533eb058c5480fa4aeec5b72196716 |
| institution | Directory Open Access Journal |
| issn | 2666-9153 |
| language | English |
| last_indexed | 2024-03-10T09:25:24Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Affective Disorders Reports |
| spelling | doaj.art-2d533eb058c5480fa4aeec5b721967162023-11-22T04:49:03ZengElsevierJournal of Affective Disorders Reports2666-91532023-12-0114100644Application of functional connectivity neurofeedback in patients with treatment-resistant depression: A preliminary reportMasahiro Takamura0Go Okada1Toshiharu Kamishikiryo2Eri Itai3Miyuki Kato4Tomokazu Motegi5Jessica Elizabeth Taylor6Toshinori Yoshioka7Mitsuo Kawato8Yasumasa Okamoto9Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan; Department of Neurology, Faculty of Medicine, Shimane University, Izumo, JapanDepartment of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, Japan; Corresponding author.Department of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, JapanDepartment of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, JapanDepartment of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, JapanBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, JapanBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, JapanBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan; XNef Inc., Kyoto, JapanBrain Information Communication Research Laboratory Group, Advanced Telecommunications Research Institute International, Kyoto, Japan; XNef Inc., Kyoto, JapanDepartment of Psychiatry and Neurosciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8553, JapanFunctional connectivity neurofeedback (FCNef) is a technique that modulates synchronous neural activity through training and is being investigated as a potential novel treatment for patients suffering from treatment-resistant depression (TRD). An FCNef protocol, based on the analysis of resting-state functional imaging data from a large cohort of depressed individuals, has been proposed to promote negative functional connectivity between the dorsolateral prefrontal cortex and the posterior cingulate cortex (DLPFC-PCC FC). This study aimed to assess the therapeutic efficacy and practicality of the protocol in a small sample of TRD patients. Of the six patients recruited, five completed the FCNef sessions. Depression and rumination scores significantly improved post-treatment, however, there were no significant changes in DLPFC-PCC FC. The study demonstrated efficacy of FCNef in ameliorating depressive symptoms, yet, it also indicated that the training itself may be burdensome for depressed patients, as evidenced by participants reporting fatigue (one of whom dropped out). Thus, a more efficient and less burdensome protocol is needed for future investigations and applications.http://www.sciencedirect.com/science/article/pii/S2666915323001828FMRIFunctional connectivity neurofeedbackTreatment resistant depressionDorsolateral prefrontal cortexPosterior cingulate cortex |
| spellingShingle | Masahiro Takamura Go Okada Toshiharu Kamishikiryo Eri Itai Miyuki Kato Tomokazu Motegi Jessica Elizabeth Taylor Toshinori Yoshioka Mitsuo Kawato Yasumasa Okamoto Application of functional connectivity neurofeedback in patients with treatment-resistant depression: A preliminary report Journal of Affective Disorders Reports FMRI Functional connectivity neurofeedback Treatment resistant depression Dorsolateral prefrontal cortex Posterior cingulate cortex |
| title | Application of functional connectivity neurofeedback in patients with treatment-resistant depression: A preliminary report |
| title_full | Application of functional connectivity neurofeedback in patients with treatment-resistant depression: A preliminary report |
| title_fullStr | Application of functional connectivity neurofeedback in patients with treatment-resistant depression: A preliminary report |
| title_full_unstemmed | Application of functional connectivity neurofeedback in patients with treatment-resistant depression: A preliminary report |
| title_short | Application of functional connectivity neurofeedback in patients with treatment-resistant depression: A preliminary report |
| title_sort | application of functional connectivity neurofeedback in patients with treatment resistant depression a preliminary report |
| topic | FMRI Functional connectivity neurofeedback Treatment resistant depression Dorsolateral prefrontal cortex Posterior cingulate cortex |
| url | http://www.sciencedirect.com/science/article/pii/S2666915323001828 |
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