Discovery of novel small-molecule aldehyde dehydrogenase 2 activators based on drug repurposing
Aldehyde dehydrogenase 2 (ALDH2) plays an important role in the detoxification of reactive aldehydes under oxidative stress. Because an estimated 50% of East Asians carry a common ALDH2 deficient variant with decreased enzyme activity and are more susceptible to toxic aldehydes, more recent findings...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-11-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S131961032300131X |