Discovery of novel small-molecule aldehyde dehydrogenase 2 activators based on drug repurposing

Discovery of novel small-molecule aldehyde dehydrogenase 2 activators based on drug repurposing

Aldehyde dehydrogenase 2 (ALDH2) plays an important role in the detoxification of reactive aldehydes under oxidative stress. Because an estimated 50% of East Asians carry a common ALDH2 deficient variant with decreased enzyme activity and are more susceptible to toxic aldehydes, more recent findings...

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Bibliographic Details
Main Authors:	Wei Tian, Xiangpei Sun, Xing Gao, Wentao Wang, Zhuo Chen, Xin Chen, Canhui Zheng
Format:	Article
Language:	English
Published:	Elsevier 2023-11-01
Series:	Journal of Saudi Chemical Society
Subjects:	Aldehyde dehydrogenase-2 Activator Virtual screening Docking Pharmacophore Drug repurposing
Online Access:	http://www.sciencedirect.com/science/article/pii/S131961032300131X

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