Measuring the Contrast Sensitivity Function in Non-Neovascular and Neovascular Age-Related Macular Degeneration: The Quantitative Contrast Sensitivity Function Test
Age-related macular degeneration (AMD) affects various aspects of visual function compromising patients’ functional vision and quality of life. Compared to visual acuity, contrast sensitivity correlates better with vision-related quality of life and subjectively perceived visual impairment. It may a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/13/2768 |
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| author | Filippos Vingopoulos Karen M. Wai Raviv Katz Demetrios G. Vavvas Leo A. Kim John B. Miller |
| author_facet | Filippos Vingopoulos Karen M. Wai Raviv Katz Demetrios G. Vavvas Leo A. Kim John B. Miller |
| author_sort | Filippos Vingopoulos |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) affects various aspects of visual function compromising patients’ functional vision and quality of life. Compared to visual acuity, contrast sensitivity correlates better with vision-related quality of life and subjectively perceived visual impairment. It may also be affected earlier in the course of AMD than visual acuity. However, lengthy testing times, coarse sampling and resolution, and poor test–retest reliability of the existing contrast testing methods have limited its widespread adoption into routine clinical practice. Using active learning principles, the qCSF can efficiently measure contrast sensitivity across multiple spatial frequencies with both high sensitivity in detecting subtle changes in visual function and robust test–retest reliability, emerging as a promising visual function endpoint in AMD both in clinical practice and future clinical trials. |
| first_indexed | 2024-03-10T10:05:19Z |
| format | Article |
| id | doaj.art-2d55ce82c7f140038e4c58b9f2040c2e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T10:05:19Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2d55ce82c7f140038e4c58b9f2040c2e2023-11-22T01:32:05ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-011013276810.3390/jcm10132768Measuring the Contrast Sensitivity Function in Non-Neovascular and Neovascular Age-Related Macular Degeneration: The Quantitative Contrast Sensitivity Function TestFilippos Vingopoulos0Karen M. Wai1Raviv Katz2Demetrios G. Vavvas3Leo A. Kim4John B. Miller5Harvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles St., Boston, MA 02114, USARetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, 243 Charles St., Boston, MA 02114, USAHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles St., Boston, MA 02114, USARetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, 243 Charles St., Boston, MA 02114, USARetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, 243 Charles St., Boston, MA 02114, USAHarvard Retinal Imaging Lab, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles St., Boston, MA 02114, USAAge-related macular degeneration (AMD) affects various aspects of visual function compromising patients’ functional vision and quality of life. Compared to visual acuity, contrast sensitivity correlates better with vision-related quality of life and subjectively perceived visual impairment. It may also be affected earlier in the course of AMD than visual acuity. However, lengthy testing times, coarse sampling and resolution, and poor test–retest reliability of the existing contrast testing methods have limited its widespread adoption into routine clinical practice. Using active learning principles, the qCSF can efficiently measure contrast sensitivity across multiple spatial frequencies with both high sensitivity in detecting subtle changes in visual function and robust test–retest reliability, emerging as a promising visual function endpoint in AMD both in clinical practice and future clinical trials.https://www.mdpi.com/2077-0383/10/13/2768contrast sensitivity functionvisual function metricsqCSFage-related macular degenerationcontrast sensitivity |
| spellingShingle | Filippos Vingopoulos Karen M. Wai Raviv Katz Demetrios G. Vavvas Leo A. Kim John B. Miller Measuring the Contrast Sensitivity Function in Non-Neovascular and Neovascular Age-Related Macular Degeneration: The Quantitative Contrast Sensitivity Function Test Journal of Clinical Medicine contrast sensitivity function visual function metrics qCSF age-related macular degeneration contrast sensitivity |
| title | Measuring the Contrast Sensitivity Function in Non-Neovascular and Neovascular Age-Related Macular Degeneration: The Quantitative Contrast Sensitivity Function Test |
| title_full | Measuring the Contrast Sensitivity Function in Non-Neovascular and Neovascular Age-Related Macular Degeneration: The Quantitative Contrast Sensitivity Function Test |
| title_fullStr | Measuring the Contrast Sensitivity Function in Non-Neovascular and Neovascular Age-Related Macular Degeneration: The Quantitative Contrast Sensitivity Function Test |
| title_full_unstemmed | Measuring the Contrast Sensitivity Function in Non-Neovascular and Neovascular Age-Related Macular Degeneration: The Quantitative Contrast Sensitivity Function Test |
| title_short | Measuring the Contrast Sensitivity Function in Non-Neovascular and Neovascular Age-Related Macular Degeneration: The Quantitative Contrast Sensitivity Function Test |
| title_sort | measuring the contrast sensitivity function in non neovascular and neovascular age related macular degeneration the quantitative contrast sensitivity function test |
| topic | contrast sensitivity function visual function metrics qCSF age-related macular degeneration contrast sensitivity |
| url | https://www.mdpi.com/2077-0383/10/13/2768 |
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