A combination of stromal PD‐L1 and tumoral nuclear β‐catenin expression as an indicator of colorectal carcinoma progression and resistance to chemoradiotherapy in locally advanced rectal carcinoma

A combination of stromal PD‐L1 and tumoral nuclear β‐catenin expression as an indicator of colorectal carcinoma progression and resistance to chemoradiotherapy in locally advanced rectal carcinoma

Abstract Programmed cell death‐1 (PD‐1) and its ligand (PD‐L1) are significant mediators of immune suppression in the tumor microenvironment. We focused on the immunological impact of PD‐1/PD‐L1 signaling during tumor progression in colorectal carcinoma (CRC) and its association with resistance to n...

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Bibliographic Details
Main Authors: Hiroyuki Takahashi, Hirono Watanabe, Miki Hashimura, Toshihide Matsumoto, Ako Yokoi, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Makoto Saegusa
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:The Journal of Pathology: Clinical Research
Subjects:
PD‐L1
PD‐1
β‐catenin
colorectal carcinoma
cancer stem cell
neoadjuvant chemoradiotherapy
Online Access:https://doi.org/10.1002/cjp2.285

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